Results 21 to 30 of about 3,785 (215)

The Phosphodiesterases in the Rat Pancreas [PDF]

European Journal of Biochemistry, 1970
The purification of two phosphodiesterases found in the rat pancreas is described. The phosphodiesterase I, an enzyme of the snake venom type, has been purified about 500 times, the phosphodiesterase II, an enzyme of the spleen type, about 60 times. The phosphodiesterase I activity, optimal at a pH of about 9.0, is completely dependent on the presence ...
W J, van Venrooij, C, Poort
openaire   +2 more sources

Influence of N-phenyl-2-naphthylamine on the Activity of Adenylate Cyclase Signaling System and the Virulence of Clavibacter michiganensis subsp. sepedonicus [PDF]

Journal of Stress Physiology & Biochemistry, 2016
The effect of N-phenyl-2-naphthylamine was obtained from exudates of pea root on growth, virulence and signaling-specific of potato phytopathogen Clavibacter michiganensis subsp. sepedonicus. It is shown that the compound in a physiological concentration
A.M. Goncharova
doaj  

BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation

mBio, 2017
The bacterial second messenger cyclic dimeric GMP (c-di-GMP) is a nearly ubiquitous intracellular signaling molecule involved in the transition from the motile to the sessile/biofilm state in bacteria.
Ricardo N. Moreira, Clémentine Dressaire, Susana Barahona, Lisete Galego, Volkhard Kaever, Urs Jenal, Cecília M. Arraiano   +6 more
doaj   +1 more source

Portopulmonary hypertension practice patterns after liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose, Elizabeth J. Kopras, Shimul A. Shah, Jean M. Elwing   +3 more
wiley   +1 more source

Targeting Phosphodiesterases—Towards a Tailor-Made Approach in Multiple Sclerosis Treatment

Frontiers in Immunology, 2019
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) characterized by heterogeneous clinical symptoms including gradual muscle weakness, fatigue, and cognitive impairment.
Melissa Schepers, Melissa Schepers, Assia Tiane, Assia Tiane, Dean Paes, Dean Paes, Selien Sanchez, Ben Rombaut, Elisabeth Piccart, Elisabeth Piccart, Bart P. F. Rutten, Bert Brône, Niels Hellings, Jos Prickaerts, Tim Vanmierlo, Tim Vanmierlo   +15 more
doaj   +1 more source

An atypical GdpP enzyme linking cyclic nucleotide metabolism to osmotic tolerance and gene regulation in Mycoplasma bovis

Frontiers in Microbiology, 2023
Nucleotide second messengers play an important role in bacterial adaptation to environmental changes. Recent evidence suggests that some of these regulatory molecular pathways were conserved upon the degenerative evolution of the wall-less mycoplasmas ...
Xifang Zhu, Xifang Zhu, Xifang Zhu, Eric Baranowski, Zhiyu Hao, Xixi Li, Gang Zhao, Yaqi Dong, Yingyu Chen, Changmin Hu, Huanchun Chen, Huanchun Chen, Huanchun Chen, Huanchun Chen, Christine Citti, Aiping Wang, Aiping Wang, Aizhen Guo, Aizhen Guo, Aizhen Guo, Aizhen Guo   +20 more
doaj   +1 more source

Influence of metabolism modifiers of cyclic nucleotides on contractility of right ventricle of rat heart with intact and removed endocardial endothelium [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2010
Introduction. Endocardial endothelium, a natural biological barrier between circulating blood in heart ventricle and cells, creates a complex yet finely tuned balance of interactions with the immediate environment. Objective. We investigated the roles
Savić Slađana, Miletić Milanka, Nestorović Vojkan, Trajković Goran, Smiljić Sonja, Radović Dragica   +5 more
doaj   +1 more source

Upregulation of Phosphodiesterase 2A Augments T Cell Activation by Changing cGMP/cAMP Cross-Talk

Frontiers in Pharmacology, 2021
3′,5′-cyclic adenosine monophosphate (cAMP) is well-known for its diverse immunomodulatory properties, primarily inhibitory effects during T cell activation, proliferation, and production of pro-inflammatory cytokines.
Roberta Kurelic, Paula F. Krieg, Jana K. Sonner, Gloria Bhaiyan, Gustavo C. Ramos, Gustavo C. Ramos, Stefan Frantz, Stefan Frantz, Manuel A. Friese, Viacheslav O. Nikolaev, Viacheslav O. Nikolaev   +10 more
doaj   +1 more source

Functional Significance of the Adcy10-Dependent Intracellular cAMP Compartments

Journal of Cardiovascular Development and Disease, 2018
Mounting evidence confirms the compartmentalized structure of evolutionarily conserved 3′–5′-cyclic adenosine monophosphate (cAMP) signaling, which allows for simultaneous participation in a wide variety of physiological functions and ensures specificity,
Sofya Pozdniakova, Yury Ladilov
doaj   +1 more source

Phosphodiesterase-4 Inhibitors for Non-COPD Respiratory Diseases

Frontiers in Pharmacology, 2021
Selective phosphodiesterase (PDE) inhibitors are a class of nonsteroid anti-inflammatory drugs for treating chronic inflammatory diseases. Modulation of systemic and airway inflammation is their pivotal mechanism of action.
Theerasuk Kawamatawong
doaj   +1 more source