Results 11 to 20 of about 3,785 (215)
Cells, 2022 The therapeutic benefit of stimulating the cGMP pathway as a form of treatment to combat heart failure, as well as other fibrotic pathologies, has become well established.
Maria Faleeva +11 more
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Impaired cAMP processivity by phosphodiesterase-protein kinase A complexes in acrodysostosis
Frontiers in Molecular Biosciences, 2023 Acrodysostosis represents a group of rare genetic disorders characterized by defective skeletal development and is often accompanied by intellectual disabilities.
Varun Venkatakrishnan +4 more
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Frontiers in Cellular and Infection Microbiology, 2022 Many antigens from Mycobacterium tuberculosis (M. tuberculosis) have been demonstrated as strong immunogens and proved to have application potential as vaccine candidate antigens. Cyclic di-AMP (c-di-AMP) as a bacterial second messenger regulates various
Yanzhi Lu +11 more
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Phosphodiesterases and preeclampsia
Medical Hypotheses, 2017 Antagonizing vasodilation has been considered one of the potential mechanisms underlying the pathophysiology of preeclampsia. Phosphodiesterases hydrolyze cGMP, interfering with the action of nitric oxide on vascular smooth muscle, thus causing vasoconstriction.
Anne Brandolt, Larré +7 more
openaire +2 more sources
Dual Regulatory Role Exerted by Cyclic Dimeric GMP To Control FsnR-Mediated Bacterial Swimming
mBio, 2022 Bacterial motility has great medical and ecological significance because of its essential role in bacterial survival and pathogenesis. Cyclic dimeric GMP (c-di-GMP), a second messenger in bacteria, is the predominant regulator of flagellar synthesis and ...
Xin Zhang +7 more
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NAFLD‐related hepatocellular carcinoma: The growing challenge
Hepatology, EarlyView., 2022 Risk and protective factors for NAFLD‐related hepatocellular carcinoma Abstract Hepatocellular carcinoma (HCC) is a common cause of cancer‐related mortality and morbidity worldwide. With the obesity pandemic, NAFLD‐related HCC is contributing to the burden of disease exponentially.
Pir Ahmad Shah +2 more
wiley +1 more source
Molecules, 2014 In this study, we investigated the relaxant action of galetin 3,6-dimethyl ether (FGAL) on rat aorta. The flavonoid relaxed both PMA‑ and phenylephrine (Phe)-induced contractions (pD2 = 5.36 ± 0.11 and 4.17 ± 0.10, respectively), suggesting the ...
Cibério L. Macêdo +7 more
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Phosphodiesterase induction in Dictyostelium discoideum by inhibition of extracellular phosphodiesterase activity [PDF]
Developmental Biology, 1982 Adenosine 3’,5’-monophosphate (cAMP) is a chemoattractant in Dictyostelium discoideum; it also induces phosphodiesterase activity. Recently it was shown that N’-(aminohexyl)adenosine 3’,5’-monophosphate (hexyl-cAMP) effectively induced phosphodiesterase activity, while this compound was chemotactically inactive and did not effectively bind to the cell ...
Haastert, Peter J.M. van +2 more
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Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae
Frontiers in Microbiology, 2017 Bacteria often use cyclic dinucleotides as second messengers for signal transduction. While the classical molecule c-di-GMP is involved in lifestyle selection, the functions of the more recently discovered signaling nucleotide cyclic di-AMP are less ...
Cedric Blötz +5 more
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Frontiers in Microbiology, 2016 Cyclic diguanylate (c-di-GMP) is essential for Yersinia pestis biofilm formation, which is important for flea-borne blockage-dependent plague transmission.
Gai-Xian eRen +4 more
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