Results 31 to 40 of about 116,729 (252)

Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. [PDF]

, 2013
The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV). Eventually, in a tightly regulated process called egress, proteins of the PV and intracellular merozoite surface are modified by an essential parasite serine ...
Baker, David A, Strath Malcolm, Maria Penzo, David A Baker, Hackett Fiona, Penzo, Maria, Blackman, Michael J, Michael J Blackman, David A. Baker (122252), Christine R Collins, Fiona Hackett (27620), Christine R. Collins, Strath, Malcolm, Withers-Martinez, Chrislaine, David A. Baker, Michael J. Blackman, Malcolm Strath (411645), Withers-Martinez Chrislaine, Penzo Maria, Chrislaine Withers-Martinez, Malcolm Strath, Collins Christine R., Hackett, Fiona, Fiona Hackett, Chrislaine Withers-Martinez (27619), Baker David A., Collins, Christine R, Christine R. Collins (191982), Michael J. Blackman (192013), Blackman Michael J., Maria Penzo (411646)   +30 more
core   +1 more source

Mechanisms Underlying Vasorelaxation Induced in Rat Aorta by Galetin 3,6-Dimethyl Ether, a Flavonoid from Piptadenia stipulacea (Benth.) Ducke

Molecules, 2014
In this study, we investigated the relaxant action of galetin 3,6-dimethyl ether (FGAL) on rat aorta. The flavonoid relaxed both PMA‑ and phenylephrine (Phe)-induced contractions (pD2 = 5.36 ± 0.11 and 4.17 ± 0.10, respectively), suggesting the ...
Cibério L. Macêdo, Luiz H. C. Vasconcelos, Ana C. de C. Correia, Italo R. R. Martins, Daysianne P. de Lira, Bárbara V. de O. Santos, Fabiana de A. Cavalcante, Bagnólia A. da Silva   +7 more
doaj   +1 more source

Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae

Frontiers in Microbiology, 2017
Bacteria often use cyclic dinucleotides as second messengers for signal transduction. While the classical molecule c-di-GMP is involved in lifestyle selection, the functions of the more recently discovered signaling nucleotide cyclic di-AMP are less ...
Cedric Blötz, Katrin Treffon, Volkhard Kaever, Frank Schwede, Elke Hammer, Jörg Stülke   +5 more
doaj   +1 more source

Differential regulation of c-di-GMP metabolic enzymes by environmental signals modulates biofilm formation in Yersinia pestis

Frontiers in Microbiology, 2016
Cyclic diguanylate (c-di-GMP) is essential for Yersinia pestis biofilm formation, which is important for flea-borne blockage-dependent plague transmission.
Gai-Xian eRen, Sai eFan, Xiao-Peng eGuo, Shiyun eChen, Yi-Cheng eSun   +4 more
doaj   +1 more source

Sildenafil Citrate-Restored eNOS and PDE5 Regulation in Sickle Cell Mouse Penis Prevents Priapism Via Control of Oxidative/Nitrosative Stress [PDF]

, 2013
Sildenafil citrate revolutionized the practice of sexual medicine upon its federal regulatory agency approval approximately 15 years ago as the prototypical phosphodiesterase type 5 inhibitor indicated for the treatment of male erectile dysfunction.
Berkowitz, Dan E, Biljana Musicki, Trinity J Bivalacqua, Musicki Biljana, Berkowitz, DE, Bivalacqua, TJ, Lewis L Hsu, Biljana Musicki (429541), Burnett, Arthur L, Hunter C Champion, Lewis L. Hsu (7926017), Dan E. Berkowitz (7926020), Arthur L. Burnett (7926023), Trinity J. Bivalacqua (7926014), Champion Hunter C., Musicki, Biljana, Burnett Arthur L., Hsu, LL, Hsu Lewis L., Hunter C. Champion (6834875), Bivalacqua Trinity J., Champion, HC, Arthur L Burnett, Hsu, Lewis L, Dan E Berkowitz, Burnett, AL, Champion, Hunter C, Bivalacqua, Trinity J, Berkowitz Dan E., Musicki, B   +29 more
core   +2 more sources

Influence of N-phenyl-2-naphthylamine on the Activity of Adenylate Cyclase Signaling System and the Virulence of Clavibacter michiganensis subsp. sepedonicus [PDF]

Journal of Stress Physiology & Biochemistry, 2016
The effect of N-phenyl-2-naphthylamine was obtained from exudates of pea root on growth, virulence and signaling-specific of potato phytopathogen Clavibacter michiganensis subsp. sepedonicus. It is shown that the compound in a physiological concentration
A.M. Goncharova
doaj  

BolA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation

mBio, 2017
The bacterial second messenger cyclic dimeric GMP (c-di-GMP) is a nearly ubiquitous intracellular signaling molecule involved in the transition from the motile to the sessile/biofilm state in bacteria.
Ricardo N. Moreira, Clémentine Dressaire, Susana Barahona, Lisete Galego, Volkhard Kaever, Urs Jenal, Cecília M. Arraiano   +6 more
doaj   +1 more source

Targeting Phosphodiesterases—Towards a Tailor-Made Approach in Multiple Sclerosis Treatment

Frontiers in Immunology, 2019
Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system (CNS) characterized by heterogeneous clinical symptoms including gradual muscle weakness, fatigue, and cognitive impairment.
Melissa Schepers, Melissa Schepers, Assia Tiane, Assia Tiane, Dean Paes, Dean Paes, Selien Sanchez, Ben Rombaut, Elisabeth Piccart, Elisabeth Piccart, Bart P. F. Rutten, Bert Brône, Niels Hellings, Jos Prickaerts, Tim Vanmierlo, Tim Vanmierlo   +15 more
doaj   +1 more source

An atypical GdpP enzyme linking cyclic nucleotide metabolism to osmotic tolerance and gene regulation in Mycoplasma bovis

Frontiers in Microbiology, 2023
Nucleotide second messengers play an important role in bacterial adaptation to environmental changes. Recent evidence suggests that some of these regulatory molecular pathways were conserved upon the degenerative evolution of the wall-less mycoplasmas ...
Xifang Zhu, Xifang Zhu, Xifang Zhu, Eric Baranowski, Zhiyu Hao, Xixi Li, Gang Zhao, Yaqi Dong, Yingyu Chen, Changmin Hu, Huanchun Chen, Huanchun Chen, Huanchun Chen, Huanchun Chen, Christine Citti, Aiping Wang, Aiping Wang, Aizhen Guo, Aizhen Guo, Aizhen Guo, Aizhen Guo   +20 more
doaj   +1 more source

Effect of vardenafil on diabetic foot ulcer (DFU) in rats

Zagazig Journal of Pharmaceutical Sciences, 2018
The present study was designed to investigate the possible effect of vardenafil phosphodiesterase-5 inhibitor on diabetic foot ulcer induced in rats and the underlying mechanism(s).
Hany Anwer , Waleed Barakat , Mona F Mahmoud   +2 more
doaj   +1 more source