Results 61 to 70 of about 89,654 (264)

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Rv2577 of Mycobacterium tuberculosis Is a Virulence Factor With Dual Phosphatase and Phosphodiesterase Functions

Frontiers in Microbiology, 2020
Tuberculosis, a lung disease caused by Mycobacterium tuberculosis (Mtb), is one of the ten leading causes of death worldwide affecting mainly developing countries. Mtb can persist and survive inside infected cells through modulation of host antibacterial
Marina Andrea Forrellad, Federico Carlos Blanco, Rubén Marrero Diaz de Villegas, Cristina Lourdes Vázquez, Agustín Yaneff, Elizabeth Andrea García, Maximiliano Gabriel Gutierrez, Rosario Durán, Andrea Villarino, Fabiana Bigi   +9 more
doaj   +1 more source

Phosphatase activities and available nutrients in soil aggregates affected by straw returning to a calcareous soil under the maize–wheat cropping system

Frontiers in Environmental Science, 2023
The objective of this study was to investigate the effects of different rates of straw returning on soil aggregate stability, phosphatase activities, and the available nitrogen (N) and phosphorus (P) within different soil aggregate sizes.
Xiang-Jie Lin, Xiang-Jie Lin, Guang-Na Zhang, Zhen Wang, Qing-Dian Han, Peng Leng   +5 more
doaj   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Ribonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line

eLife, 2017
ADAR1 isoforms are adenosine deaminases that edit and destabilize double-stranded RNA reducing its immunostimulatory activities. Mutation of ADAR1 leads to a severe neurodevelopmental and inflammatory disease of children, Aicardi-Goutiéres syndrome.
Yize Li, Shuvojit Banerjee, Stephen A Goldstein, Beihua Dong, Christina Gaughan, Sneha Rath, Jesse Donovan, Alexei Korennykh, Robert H Silverman, Susan R Weiss   +9 more
doaj   +1 more source

Evaluating aminophylline and progesterone combination treatment to modulate contractility and labor‐related proteins in pregnant human myometrial tissues

Pharmacology Research & Perspectives, 2021
Progesterone (P4) and cyclic adenosine monophosphate (cAMP) are regarded as pro‐quiescent factors that suppress uterine contractions during pregnancy.
Pei F. Lai, Roger C. Young, Rachel M. Tribe, Mark R. Johnson   +3 more
doaj   +1 more source

Exploratory Analysis of Factors Associated With the Recovery of Erectile Dysfunction After Rectal Cancer Surgery (Sub‐Analysis of LANDMARC Trial)

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background Erectile dysfunction (ErD) is an important complication after rectal cancer surgery, however a substantial proportion of patients experience functional recovery over time. Evidence regarding which patients are more likely to recover remains limited.
Ryosuke Mizuno, Koya Hida, Masakatsu Numata, Takashi Sakamoto, Kazutaka Obama, Akio Shiomi, Ryo Inada, Manabu Shiozawa, Mayumi Ozawa, Masanori Hotchi, Daisuke Yamamoto, Suguru Hasegawa, Masashi Miguchi, Shinobu Ohnuma, Tomohiro Yamaguchi, Tomonori Akagi, Yusuke Kinugasa, Shigeki Yamaguchi, Hiroyasu Kagawa, Masahiko Watanabe, Takeshi Naitoh, Ichiro Takemasa   +21 more
wiley   +1 more source

Potential Roles of PDE4 Inhibitors in Peptic Ulcer Treatment

Клинический разбор в общей медицине
Introduction. Peptic ulcer disease, a common gastrointestinal disorder, is mostly caused by Helicobacter pylori infection, non-steroidal anti-inflammatory drug usage, and lifestyle factors including alcohol use and smoking.
Khaled A. Abdel-Sater
doaj   +1 more source

A Genome-Wide Screen Identifies Genes in Rhizosphere-Associated Pseudomonas Required to Evade Plant Defenses

mBio, 2018
Pseudomonas fluorescens and related plant root (“rhizosphere”)-associated species contribute to plant health by modulating defenses and facilitating nutrient uptake.
Zhexian Liu, Polina Beskrovnaya, Ryan A. Melnyk, Sarzana S. Hossain, Sophie Khorasani, Lucy R. O’Sullivan, Christina L. Wiesmann, Jen Bush, Joël D. Richard, Cara H. Haney   +9 more
doaj   +1 more source

A Dose-Ranging Study of the Novel Inhaled Dual PDE 3 and 4 Inhibitor Ensifentrine in Patients with COPD Receiving Maintenance Tiotropium Therapy

International Journal of COPD, 2021
Gary T Ferguson,1 Edward M Kerwin,2 Tara Rheault,3 Thomas Bengtsson,4 Kathleen Rickard3 1Pulmonary Research Institute of Southeast Michigan, Farmington Hills, MI, USA; 2Altitude Clinical Consulting, Medford, OR, USA; 3Verona Pharma, Plc, Raleigh, NC, USA;
Ferguson GT, Kerwin EM, Rheault T, Bengtsson T, Rickard K   +4 more
doaj