Results 81 to 90 of about 93,838 (303)
Andrology, Volume 11, Issue 2, Page 257-269, February 2023., 2023 Abstract Introduction Erectile dysfunction is associated with diabetes mellitus with an estimated prevalence of 52.5% in the diabetic population. The first‐line therapy for erectile dysfunction is phosphodiesterase type 5 inhibitors, but data suggest that diabetic men may be less responsive than non‐diabetic men.
Axel Alberto Cayetano‐Alcaraz +4 more
wiley +1 more source
Journal of the American Heart Association: Cardiovascular and Cerebrovascular DiseaseBackground Phosphodiesterases degrade cyclic GMP (cGMP), the second messenger that mediates the cardioprotective effects of natriuretic peptides. High natriuretic peptide/cGMP ratio may reflect, in part, phosphodiesterase activity.
Leonard Chiu +11 more
doaj +1 more source
Pharmacology of the lower urinary tract
Indian Journal of Urology, 2014 Pharmacology of the lower urinary tract provides the basis for medical treatment of lower urinary tract symptoms (LUTS). Therapy of LUTS addresses obstructive symptoms (frequently explained by increased prostate smooth muscle tone and prostate ...
Martin Hennenberg +2 more
doaj +1 more source
Proceedings of the Japanese Histochemical Association, 1961 Phosphatase activity which was extracted from human intestinal mucous membrane was subsected to paper chromatography and paper elecrophoresis, using as substrate naphthyl phosphate and di-naphthyl phosphate.Phosphomonoesterase and phosphodiesterase activities were located in the same position on the chromatogram. A direct developing method was employed
Hideo Takamatsu +3 more
openaire +3 more sources
ESC Heart Failure, EarlyView.Abstract Aims Despite receiving guideline‐directed medical heart failure (HF) therapy, patients with pulmonary hypertension associated with left heart disease (PH‐LHD) experience higher mortality and hospitalization rates than the general HF population.
Marcin Ufnal +17 more
wiley +1 more source
Understanding and treating ejaculatory dysfunction in men with diabetes mellitus
Andrology, Volume 11, Issue 2, Page 379-398, February 2023., 2023 Abstract Diabetes mellitus is a rapidly rising metabolic disorder with important systemic complications. Global figures have demonstrated the prevalence of diabetes mellitus has almost quadrupled from 108 million in 1980 to 422 million in 2014, with a current prevalence of over 525 million.
Ankit Desai +4 more
wiley +1 more source
CellsThe ubiquitous second messenger 3′,5′-cyclic adenosine monophosphate (cAMP) regulates cardiac excitation-contraction coupling (ECC) by signaling in discrete subcellular microdomains.
Axel E. Kraft +7 more
doaj +1 more source
ESC Heart Failure, EarlyView.AIM This analysis provides a comparison of the efficacy of initial mono and combination therapy in patients with PAH and cardiovascular comorbidities or with risk factors of HFpEF (heart failure with preserved ejection fractioin).METHOD Data from the European COMPERA registry were used for a matched pair analysis.
Dirk Skowasch +20 more
wiley +1 more source
Andrology, Volume 11, Issue 2, Page 316-331, February 2023., 2023 Abstract Background Currently, patients with diabetic erectile dysfunction (DMED) were not satisfied with the effects of first‐line phosphodiesterase type 5 inhibitors (PDE5Is). Hence, this paper was designed to mine hub biomarkers in DMED and explore its potential mechanisms.
Yi Wang +4 more
wiley +1 more source
Frontiers in Microbiology, 2016 The Gram-positive model organism Bacillus subtilis produces the essential second messenger signaling nucleotide cyclic di-AMP. In B. subtilis and other bacteria, c-di-AMP has been implicated in diverse functions such as control of metabolism, cell ...
Jan eGundlach +4 more
doaj +1 more source