Results 81 to 90 of about 92,115 (249)

Cyclic nucleotide specificity of the activator and catalytic sites of a cGMP-stimulated cGMP phosphodiesterase from Dictyostelium discoideum [PDF]

, 1985
The cellular slime mold Dictyostelium discoideum has an intracellular phosphodiesterase which specifically hydrolyzes cGMP. The enzyme is activated by low cGMP concentrations, and is involved in the reduction of chemoattractant-mediated elevations of ...
Baraniak, Janina,, Bulgakov, Roman,, Haastert, Peter J.M. van,, Jastorff, Bernd,, Kesbeke, Fanja,, Morr, Michael,, Petridis, Georg,, Seela, Frank,, Stec, Wojciech J.,   +8 more
core   +2 more sources

Regioselective C‐H Thio‐ and Selenocyanation of Pyrazolo[1,5‐a]pyrimidines

Chemistry – An Asian Journal, EarlyView.
A metal‐free, N‐chlorosuccinimide (NCS) mediated, highly efficient, and regioselective C−H thiocyanation and C−H selenocyanation of pyrazolo[1,5‐a]pyrimidines are achieved under mild reaction conditions for the synthesis of a wide variety of 3‐thiocyanato‐ and 3‐selenocyanatopyrazolo[1,5‐a]pyrimidines in good to excellent yield up to 99 %.
Paramita Pattanayak, Harshil Khandelwal, Shreeja Basappa, Tanmay Chatterjee   +3 more
wiley   +1 more source

Mutations in phosphodiesterase 6 identified in familial cases of retinitis pigmentosa. [PDF]

, 2016
To delineate the genetic determinants associated with retinitis pigmentosa (RP), a hereditary retinal disorder, we recruited four large families manifesting cardinal symptoms of RP. We localized these families to regions on the human genome harboring the
Akram, Javed, Ayyagari, Radha, Gottsch, Clare Brooks S, Guru, Aditya A, Kabir, Firoz, Khan, Shaheen N, Naeem, Muhammad Asif, Riazuddin, S Amer, Riazuddin, Sheikh, Ullah, Inayat   +9 more
core   +2 more sources

Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell.
Dan Shan, Jinling Song, Yuqing Ren, Yuyuan Zhang, Yuhao Ba, Peng Luo, Quan Cheng, Hui Xu, Siyuan Weng, Anning Zuo, Shutong Liu, Xinwei Han, Jinhai Deng, Zaoqu Liu   +13 more
wiley   +1 more source

Effects of diet and antihyperglycemic drugs on erectile dysfunction: A systematic review

Andrology, Volume 11, Issue 2, Page 282-294, February 2023., 2023
Abstract Background Erectile dysfunction is recognized as one of the complications of diabetes mellitus. To date, a wide gap of knowledge is present on the efficacy of pharmacological treatments of diabetes mellitus on erectile function, acting not only through metabolic control. Similarly, the effects of different diet regimens on erectile dysfunction
Giuseppe Defeudis, Rossella Mazzilli, Alfonso Maria Di Tommaso, Virginia Zamponi, Francesco Carlomagno, Dario Tuccinardi, Mikiko Watanabe, Antongiulio Faggiano, Daniele Gianfrilli   +8 more
wiley   +1 more source

DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1 [PDF]

, 2007
DNA single-strand breaks (SSBs) are the commonest DNA lesions arising spontaneously in cells, and if not repaired may block transcription or may be converted into potentially lethal/clastogenic DNA double-strand breaks (DSBs).
Arnaudeau, Avemann, Barzilai, Bendixen, Caldecott, Caldecott, Cheng, Chrencik, Christiansen, Clements, Connelly, Culmsee, Daroui, Date, Davies, Davies, Davies, de Boer, Deng, D’Arpa, El-Khamisy, Flangas, Furuta, Godthelp, Hinz, Holm, Horwitz, Hsiang, Inamdar, Interthal, Interthal, Interthal, K.W. Caldecott, Kroeger, Lanza, Lesher, Liao, Lindahl, Liu, Mol, Moreira, Morris, Nitiss, Nouspikel, O’Driscoll, Parsons, Plo, Pommier, Pommier, Pommier, Poot, Pouliot, Pouliot, Pourquier, Pourquier, Pourquier, Pourquier, Pourquier, Rideout, Ryan, Ryan, S.F. El-Khamisy, Sarkander, Sarkander, Shao, Stewart, Strumberg, Takashima, Taylor, Thompson, van Waardenburg, Vance, Vidal, Vierck, Wang, Whitehouse, Wilson, Wu, Wu, Yan, Yang, Zhou, Zhou   +82 more
core   +1 more source

IGFBP5 antisense and short hairpin RNA (shRNA) constructs improve erectile function by inducing cavernosum angiogenesis in diabetic mice

Andrology, Volume 11, Issue 2, Page 358-371, February 2023., 2023
Abstract Background The incidence of diabetic erectile dysfunction (ED) is rapidly increasing, and due to the severe angiopathy caused by diabetes, current drugs are ineffective at treating ED. Insulin‐like growth factor‐binding protein 5 (IGFBP5) promotes cell death and induces apoptosis in various cell types.
Jiyeon Ock, Jun‐Kyu Suh, Soon‐Sun Hong, Ju‐Hee Kang, Guo Nan Yin, Ji‐Kan Ryu   +5 more
wiley   +1 more source

Studies of glucagon resistance in large rat adipocytes: 125I-labeled glucagon binding and lipolytic capacity

Journal of Lipid Research, 1974
This study is concerned with potential modifications of large fat cells from adult rats (400–450 g) that make them resistant to stimulation by glucagon. The lipolytic capacity and 125I-labeled glucagon-binding capability of these cells were compared with
James N. Livingston, Pedro Cuatrecasas, Dean H. Lockwood   +2 more
doaj  

Use of phosphodiesterase 4 inhibitor in patients with psoriatic arthritis

Современная ревматология, 2017
Psoriatic arthritis (PsA) is a chronic inflammatory disease of the joints, spine, and entheses, which is associated with psoriasis. The pathological process is localized mainly in the tissues of the locomotor system and leads to the development of ...
V. I. Mazurov, E. A. Trofimov
doaj   +1 more source

Cyclic AMP signalling in pancreatic islets [PDF]

, 2010
Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian, Ong, Wee Kiat, Pyne, Nigel J.   +2 more
core   +1 more source