Results 191 to 200 of about 47,423 (289)

From Celecoxib to a Novel Class of Phosphodiesterase 5 Inhibitors: Trisubstituted Pyrazolines as Novel Phosphodiesterase 5 Inhibitors with Extremely High Potency and Phosphodiesterase Isozyme Selectivity

, 2021
Mohammad Abdel‐Halim, Sara Sigler, Nora A. S. Racheed, Amr Hefnawy, Reem K. Fathalla, Mennatallah A. Hammam, Ahmed Maher, Yulia Maxuitenko, Adam B. Keeton, Rolf W. Hartmann, Matthias Engel, Gary A. Piazza, Alireza Abadi   +12 more
openalex   +1 more source

Pathogenesis and Therapeutics for Chronic Pruritus of Unknown Origin: A Systematic Review

International Journal of Dermatology, EarlyView.
ABSTRACT Chronic pruritus of unknown origin (CPUO) is a distressing condition characterized by persistent itch lasting over 6 weeks without an identifiable cause. The underlying mechanisms remain poorly understood, complicating diagnosis and treatment.
Yagiz Matthew Akiska, Isha Gandhi, Robert Adler, Deena Fayyad, Perya Bhagchandani, Shabnam Afzal, Waleed Adawi, Shivani Patel, Shawn G. Kwatra   +8 more
wiley   +1 more source

Prognosis and Treatment With Phosphodiesterase 5 Inhibitors in Combined Post- and Precapillary Pulmonary Hypertension: A Propensity Score-Matched Analysis From the Hellenic Pulmonary Hypertension Registry. [PDF]

Pulm Circ
Papadopoulos GE, Arvanitaki A, Mouratoglou SA, Gourgiotis P, Chrysochoidis-Trantas T, Mpatsouli A, Bechlioulis A, Naka A, Demerouti E, Karyofyllis P, Tsiapras D, Anthi A, Manginas A, Ziakas A, Rosenkranz S, Giannakoulas G.   +15 more
europepmc   +1 more source

The effectiveness of psychological interventions alone, or in combination with phosphodiesterase-5 inhibitors, for the treatment of erectile dysfunction:A systematic review. [PDF]

Arab J Urol, 2021
Atallah S, Haydar A, Jabbour T, Kfoury P, Sader G.   +4 more
europepmc   +1 more source

Elevated Salivary Theobromine and Long‐Term Improvement of Periodontal Health in Two Cohort Studies

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Background Theobromine, a methylxanthine mainly found in chocolate, has been suggested to possess various health‐promoting properties. This study aimed to investigate the long‐term effect of salivary theobromine levels on periodontitis severity using 7‐ and 10‐year follow‐up data from the prospective Studies of Health in Pomerania (SHIP‐TREND ...
Thomas Kocher, Sebastian‐Edgar Baumeister, Henry Völzke, Matthias Nauck, Peter Meisel, Karsten Suhre, Uwe Völker, Nele Friedrich, Birte Holtfreter   +8 more
wiley   +1 more source

Deciphering phosphodiesterase-5 inhibitors from <i>Aframemum melegueta</i>: computational models against erectile dysfunction. [PDF]

In Silico Pharmacol
Omoboyowa DA.
europepmc   +1 more source

Phosphodiesterase type 5 Inhibitors (PDE-5I) as a potential therapeutic drug in stroke: A systematic narrative review

, 2023
Harvey Sudharta, Fani Agusta Chandra, Nadya Novemia, Andre, Jimmy Barus, Poppy Kristina Sasmita   +5 more
openalex   +1 more source

Efficacy and safety of ME3183, an oral phosphodiesterase 4 inhibitor, in patients with plaque psoriasis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
We assessed four different doses of ME3183, a novel phosphodiesterase 4 inhibitor, and placebo in 132 patients with moderate to severe plaque psoriasis. At Week 16, more patients receiving ME3183 achieved ≥75% reduction in baseline Psoriasis Area and Severity Index scores than those receiving placebo, with no new safety concerns.
Kim A. Papp, April W. Armstrong, Tomokazu Koresawa, Kazunari Otake, Masayuki Hirata, Akiko Kano   +5 more
wiley   +1 more source

Risk of Ocular Adverse Events Associated With Use of Phosphodiesterase 5 Inhibitors in Men in the US.

JAMA Ophthalmol, 2022
Etminan M, Sodhi M, Mikelberg FS, Maberley D.   +3 more
europepmc   +1 more source

Use of Phosphodiesterase 5 Inhibitors in Continuous-Flow Left Ventricular Assist Device Patients With Pulmonary: Hypertension: A Contemporary Analysis [PDF]

, 2015
Veli K. Topkara, Amandine Godier-Furnémont, A. Levin, A.R. Garan, B. Cagliostro, R. Te-Frey, F. Torres, Koji Takeda, Hiroo Takayama, M. Yuzefpolskaya, Ulrich P. Jorde, Donna Mancini, Yoshifumi Naka, P.C. Colombo   +13 more
openalex   +1 more source