Results 231 to 240 of about 12,220,634 (288)
Function drives 1‐year decision regret in radical prostatectomy: a multicentre prospective study
BJU International, Volume 138, Issue 4, Page 694-704, October 2026.Objectives To identify contemporary drivers of postoperative decision regret 1 year after radical prostatectomy (RP). Patients and Methods In this prospective, multicentre study, patients undergoing robot‐assisted RP (RARP) or retropubic open RP (ORP) for localised prostate cancer at seven centres in Germany and Austria (2022–2024) completed ...
Christopher Hirtsiefer +14 more
wiley +1 more source
Cooling down for going up: Could selective ‘brain chilling’ mitigate high‐altitude illness?
Experimental Physiology, EarlyView.
Adnan Haq, Damian M. Bailey
wiley +1 more source
British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó +14 more
wiley +1 more source
PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation
International Journal of Dermatology, Volume 65, Issue 10, Page 2038-2048, October 2026.This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad +2 more
wiley +1 more source
E3 Ubiquitin Ligases in MASH‐Associated Liver Fibrosis: Mechanisms and Therapeutic Opportunities
Liver International, Volume 46, Issue 10, October 2026.ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a major cause of progressive liver fibrosis and can ultimately lead to cirrhosis and hepatocellular carcinoma (HCC). MASH‐associated liver fibrosis develops through a complex interplay among lipotoxic hepatocyte injury, oxidative and endoplasmic reticulum stress, inflammatory ...
Ah‐Reum Oh +8 more
wiley +1 more source
Phosphodiesterase 5 Inhibitors from Derris scandens
Planta Medica, 2018 AbstractPhosphodiesterase 5 inhibitors have been used as a first-line medicine for the treatment of erectile dysfunction. In the search for new phosphodiesterase 5 inhibitors from natural sources, we found that the 95% ethanol extract of Derris scandens stem showed phosphodiesterase 5 inhibitory activity with an IC50 value of about 7 µg/mL.
Nattiya, Chaichamnong +8 more
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Recreational Use and Misuse of Phosphodiesterase 5 Inhibitors
Journal of the American Pharmacists Association: JAPhA, 2005To characterize the rationale for and extent of phosphodiesterase (PDE) 5 inhibitor use in recreational settings, describe risks from such misuse, and discuss postexposure clinical management strategies.Published articles identified by searches through Medline, EMBASE, International Pharmaceutical Abstracts, and Toxline, from 1990 to March 2004, using ...
Kelly M Smith
exaly +3 more sources
New Avenues for Phosphodiesterase Inhibitors in Asthma
Journal of Experimental Pharmacology, 2021 Maria Gabriella Matera,1 Josuel Ora,2 Francesco Cavalli,2 Paola Rogliani,2,3 Mario Cazzola3 1Department of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, Italy; 2Respiratory Diseases Unit, “Tor Vergata&rdquo ...
Francesco Cavalli +2 more
exaly +2 more sources