Results 21 to 30 of about 47,423 (289)
Cardiac Uses of Phosphodiesterase-5 Inhibitors
Journal of the American College of Cardiology, 2012 Phosphodiesterase-5 inhibitors (PDE5Is) improve erectile function by enhancing nitric oxide availability in the penis and its supplying vasculature, resulting in vasodilation and increased blood flow. PDE5Is might benefit cardiovascular diseases because phosphodiesterase-5 is also located elsewhere in the body, including the pulmonary and systemic ...
Schwartz, Bryan G. +4 more
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Pharmacotherapy of erectile dysfunction: Current standards
Indian Journal of Urology, 2006 Pharmacotherapy is currently the therapeutic option of choice for erectile dysfunction. Comprising mainly intracavernosal injection therapy using alprostadil or alprostadil combined with phentolamine and/or papaverine and oral phosphodiesterase-5 ...
Kew-Kim Chew
doaj +1 more source
Applied Sciences, 2021 Alzheimer’s disease is a memory-related neurodegenerative condition leading to cognitive impairment. Cholinergic deficit, together with other underlying mechanisms, leads the to onset and progression of the disease.
Giovanni Ribaudo +2 more
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Antioxidant effects of phosphodiesterase-5 inhibitors [PDF]
Cardiovascular Research, 2013 This letter refers to ‘The phosphodiesterase-5 inhibitor vardenafil reduces oxidative stress while reversing pulmonary arterial hypertension’ by Y.-F. Fan et al ., Cardiovascular Research (2013) 99, 395–403. Fan et al .1 have shown convincing results indicating that the phosphodiesterase-5 (PDE5) inhibitor vardenafil reduces oxidative stress and this
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The World Journal of Men's Health, 2023 Purpose: To evaluate the efficacy and safety of udenafil 75 mg once daily in patients with erectile dysfunction following bilateral nerve-sparing robot-assisted laparoscopic radical prostatectomy (BNS-RALP).
Jae Hoon Chung +8 more
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PDE5 inhibitor drugs for use in dementia
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2023 Alzheimer's disease and related dementias (ADRD) remain a major health‐care challenge with few licensed medications. Repurposing existing drugs may afford prevention and treatment.
Atticus H. Hainsworth +4 more
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Membranes, 2021 Although phosphodiesterase type 5 inhibitors are widely used and well-studied drugs, the potential benefits of their application in the treatment of various diseases and new drug delivery systems, including liposome forms, are still being discussed.
Anastasiia A. Zakharova +2 more
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Evolution of Phosphodiesterase-5 Inhibitors
The World Journal of Men's Health, 2015 After the launch of sildenafil citrate (Viagra®), the last great invention of the 20th century, in 1998, oral phosphodiesterase (PDE)-5 inhibitors were established as first-line treatment for erectile dysfunction (ED), representing a paradigm shift in the diagnosis and treatment of ED [1].
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Why humans need type 5 phosphodiesterase inhibitors [PDF]
International Journal of Andrology, 2005 SummaryErectile dysfunction (ED) is a widespread medical condition affecting millions of males at any age and requiring medical treatment. ED may simply reflect a limit of human physiology, yet ED equates to genetic death and the high prevalence of ED is a clear evolutionary paradox.
CELLERINO, Alessandro, JANNINI E. A.
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FEBS Open Bio, EarlyView.Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp +13 more
wiley +1 more source