Results 61 to 70 of about 2,974,682 (398)

Cell Calcification Models and Their Implications for Medicine and Biomaterial Research

Advanced Healthcare Materials, EarlyView.
Calcification, is the process by which the tissues containing minerals are formed, occurring during normal physiological processes, or in pathological conditions. Here, it is aimed to give a comprehensive overview of the range of cell models available, and the approaches taken by these models, highlighting when and how methodological divergences arise,
Luke Hunter, Caterina Vanelli Coralli, Robert Dzhanaev, Aaron Morgan, Willi Jahnen‐Dechent, Sergio Bertazzo   +5 more
wiley   +1 more source

Combination phosphodiesterase type 4 inhibitor and phosphodiesterase type 5 inhibitor treatment reduces non-voiding contraction in a rat model of overactive bladder.

PLoS ONE, 2019
IntroductionCurrent treatments for overactive bladder (OAB) are often discontinued due to side effects or lack of efficacy. The goal of this study was to determine if combining a phosphodiesterase type 4 inhibitor (PDE4i); with a type 5 inhibitor (PDE5i);
Brian M Balog, Abhilasha Tangada, Pooja Sheth, Qi-Xiang Song, Bruna M Couri, Leah L Porras, Gary G Deng, Margot S Damaser   +7 more
doaj   +1 more source

Synergistic effect of phosphodiesterase 4 inhibitor and serum on migration of endotoxin-stimulated macrophages. [PDF]

, 2018
Macrophage migration is an essential step in host defense against infection and wound healing. Elevation of cAMP by inhibiting phosphodiesterase 4 (PDE4), enzymes that specifically degrade cAMP, is known to suppress various inflammatory responses in ...
Catherine Jin, S-L, Chuang, Tsung-Hsien, Conti, Marco, Ding, Shiau-Li, Hsiung, Te-Chih, Weng, Fu-Chun, Wu, Chin-Pyng, Yang, Jing-Xing   +7 more
core  

Effects of High Flavanol Dark Chocolate on Cardiovascular Function and Platelet Aggregation. [PDF]

, 2015
Regular consumption of chocolate and cocoa products has been linked to reduced cardiovascular mortality. This study compared the effects of high flavanol dark chocolate (HFDC; 1064mg flavanols/day for 6 weeks) and low flavanol dark chocolate (LFDC; 88mg ...
Akita, Armstrong, Atholl Johnston, Avolio, Balzer, Buijsse, Buijsse, Butcher, Curtis, Curtis, Custodis, David J. Collier, Duprez, Engler, Flammer, Flammer, Fredholm, Grassi, Grassi, Gresele, Gu, Gurvinder Rull, Heiss, Hermann, Holland, Holt, Innes, Janszky, Julian Shiel, Kokubo, Kris-Etherton, Kris-Etherton, Lakatta, Langer, Larsson, Larsson, Laurent, Lopez-Garcia, Manisty, Martina H. Lundberg, Murphy, Pereira, Rambaran, Rein, Ried, Roger Corder, Schroeter, Sever, Sharman, Smolenski, Taubert, Thorin, Timothy D. Warner, Varughese, Williams, Yu, Zetty N. Mohd-Zain   +56 more
core   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Sildenafil in Infants and Children

Children, 2017
Pulmonary arterial hypertension (PAH) management has been transformed in recent times with the advent of cheap and effective diagnostic tools and therapy.
Larisa Simonca, Robert Tulloh
doaj   +1 more source

Ibudilast, a Pharmacologic Phosphodiesterase Inhibitor, Prevents Human Immunodeficiency Virus-1 Tat-Mediated Activation of Microglial Cells

PLoS ONE, 2011
Human Immunodeficiency Virus-1 (HIV-1)-associated neurocognitive disorders (HAND) occur, in part, due to the inflammatory response to viral proteins, such as the HIV-1 transactivator of transcription (Tat), in the central nervous system (CNS).
Michelle Kiebala, S. Maggirwar
semanticscholar   +1 more source

Dual‐Functional Polyphosphoesters for Gene Delivery: Synergistic Effects of Guanidinium and Hydrophobic Side Chains in Degradable Polymers

Advanced Healthcare Materials, EarlyView.
This study presents guanidinium‐ and indole‐functionalized polyphosphoesters as degradable, non‐viral gene delivery vectors. Through precise tuning of charge density and hydrophobicity, these polymers form stable polyplexes with low toxicity. Remarkably, minor structural changes yield up to 200‐fold differences in transfection efficiency, highlighting ...
Markus Kötzsche, Andreas Dzierza, Jan Egger, Timo Rheinberger, Christin Weilandt, Frederik R. Wurm, Ivo Nischang, Dagmar Fischer, Kalina Peneva   +8 more
wiley   +1 more source

The impact of phosphodiesterase inhibition on neurobehavioral outcomes in preclinical models of traumatic and non-traumatic spinal cord injury: a systematic review

Frontiers in Medicine, 2023
Study designSystematic review.ObjectiveThe objective of this study was to evaluate the impact of phosphodiesterase (PDE) inhibitors on neurobehavioral outcomes in preclinical models of traumatic and non-traumatic spinal cord injury (SCI).MethodsA ...
Max B. Butler, Sundar K. Vellaiyappan, Faheem Bhatti, Fazal-E-Momin Syed, Amir Rafati Fard, Jye Quan Teh, Ben Grodzinski, Melika Akhbari, Sylva Adeeko, Rory Dilworth, Aniqah Bhatti, Unaiza Waheed, Sophie Robinson, Temidayo Osunronbi, Benn Walker, Luke Ottewell, Gayathri Suresh, Isla Kuhn, Benjamin M. Davies, Mark R. N. Kotter, Oliver D. Mowforth   +20 more
doaj   +1 more source

Tonic and phasic nitric oxide signals in hippocampal long-term potentiation [PDF]

, 2006
Nitric oxide ( NO) participates in long-term potentiation (LTP) and other forms of synaptic plasticity in many different brain areas but where it comes from and how it acts remain controversial.
Garthwaite, J, Hopper, RA
core   +1 more source