Results 141 to 150 of about 87,967 (330)

Inhibition of PDE‐4 isoenzyme attenuates frequency and overall contractility of agonist‐evoked ureteral phasic contractions

Pharmacology Research & Perspectives
The aim of this study was to investigate the functional role of phosphodiesterase enzymes (PDE) in the isolated porcine ureter. Distal ureteral strips were mounted in organ baths and pre‐contracted with 5‐HT (100 μM).
Iris Lim, Taishi Masutani, Hikaru Hashitani, Russ Chess‐Williams, Donna Sellers   +4 more
doaj   +1 more source

Inhibition of Colon Cancer Cell Growth by Phosphodiesterase Inhibitors Is Independent of cGMP Signaling. [PDF]

J Pharmacol Exp Ther, 2022
Hou Y, Wren A, Mylarapu N, Browning K, Islam BN, Wang R, Vega KJ, Browning DD.   +7 more
europepmc   +1 more source

EFFECTS OF CYCLIC AMP‐ AND CYCLIC GMP‐PHOSPHODIESTERASE INHIBITORS ON IMMUNOLOGICAL RELEASE OF HISTAMINE AND ON LUNG CONTRACTION [PDF]

, 1981
Nelly Frossard, Yves Landry, G. Pauli, M. Ruckstuhl   +3 more
openalex   +1 more source

Impacts of anti-inflammatory phosphodiesterase inhibitors on a murine model of chronic pulmonary inflammation. [PDF]

Pharmacol Res Perspect, 2021
Zheng XF, Chen DD, Zhu XL, Le Grange JM, Zhou LQ, Zhang JN.   +5 more
europepmc   +1 more source

EFNB3 Frameshift Variant in Weimaraner Dogs with a Condition Resembling a Congenital Mirror Movement Disorder

Movement Disorders, EarlyView.
ABSTRACT Background Congenital mirror movement disorders (CMMs) are clinically and genetically heterogeneous in human patients. CMMs have not been documented to occur spontaneously in animals. Objective The objective of this work was to document the first case of CMMs spontaneously occurring in Weimaraner dogs and to identify the underlying genetic ...
Cleo Schwarz, Florian Bartenschlager, Olivia Kershaw, Judith Braun, Julien Guevar, Vidhya Jagannathan, Jörg T. Epplen, Wencke Reineking, Wolfgang Baumgärtner, Kailash P. Bhatia, Achim D. Gruber, Tosso Leeb   +11 more
wiley   +1 more source

Phosphodiesterase Inhibitors in Acute Lung Injury: What Are the Perspectives? [PDF]

Int J Mol Sci, 2021
Mokra D, Mokry J.
europepmc   +1 more source

Early‐Onset Movement Disorder Syndrome Caused by Biallelic Variants in PDE1B Encoding Phosphodiesterase 1B

Movement Disorders, EarlyView.
Abstract Background Breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP) in basal ganglia cells through hydrolysis of diesteric bonds, primarily by PDE10A and PDE1B, is essential for normal human movement. While biallelic loss‐of‐function variants in PDE10A are known to cause hyperkinetic movement disorders, the ...
Tomer Poleg, Noam Hadar, Eyal Kristal, Nicola Y. Roberts, Vadim Dolgin, Ilana Aminov, Amit Safran, Nadav Agam, Matan Jean, Ofek Freund, Eamonn G. Sheridan, James A. Poulter, Michelle L. Thompson, Yusra Algoos, Salma Al‐Qahtani, Lama AlAbdi, Sateesh Maddirevula, Verity Hartill, Henry Houlden, Reza Maroofian, Amit Nahum, Ohad S. Birk   +21 more
wiley   +1 more source

In silico exploration of antinociceptive activity of 1,4-benzodiazepines: Molecular docking on α1 A-adrenoceptor, and phosphodiesterase 4

Regulatory Mechanisms in Biosystems
Recently, scientists have established that several benzodiazepines were found to enhance the activation of a cAMP response element pathway by α1A-adrenergic receptors, but this effect was attributed to off-target inhibition of phosphodiesterases 4.
A. S. Akisheva, V. B. Larionov, M. Y. Golovenko, O. A. Makarenko, I. P. Valivodz, I. Y. Borysiuk, Y. O. Molodan   +6 more
doaj   +1 more source

Effects of phosphodiesterase inhibitors on normal and chemically‐skinned isolated airway smooth muscle [PDF]

, 1987
Susan E. Bryson, Ian W. Rodger
openalex   +1 more source

Fat taste sensitivity in women with obesity: transcriptomic analysis of fungiform papillae before and after bariatric surgery

Obesity, EarlyView.
Abstract Objective Fat taste sensitivity has been implicated in long‐term weight loss after bariatric surgery. Unexpectedly, improvement of orosensory fat acuity was not systematic in operated patients. Methods Obesity‐induced alterations of gene expression in gustatory papillae having been recently reported, we have explored the fungiform ...
Arnaud Bernard, Corentin Richard, Loredana Radoi, Romain Boidot, Séverine Ledoux, Philippe Besnard   +5 more
wiley   +1 more source