Results 161 to 170 of about 53,329 (292)

Phosphodiesterase Inhibitors: Could They Be Beneficial for the Treatment of COVID-19? [PDF]

Int J Mol Sci, 2020
Giorgi M, Cardarelli S, Ragusa F, Saliola M, Biagioni S, Poiana G, Naro F, Massimi M.   +7 more
europepmc   +1 more source

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

Molecular Microbiology, EarlyView.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan, Sourav Roy, Revathi Govind   +2 more
wiley   +1 more source

Respiratory Cilia as a Therapeutic Target of Phosphodiesterase Inhibitors. [PDF]

Front Pharmacol, 2020
Joskova M, Mokry J, Franova S.
europepmc   +1 more source

To Move or Not to Move: When and How Bacteria Suppress Flagellar Motility

Molecular Microbiology, EarlyView.
Motility cessation in bacteria is a key regulatory strategy that provides multiple survival advantages including enhanced community cooperation, niche adaptation and evasion of host immune responses. This process is controlled by associated mechanisms such as post‐translational modifications and second messenger signalling that stabilise non‐motile ...
Fatemeh Mohaghegh, Jacob Scadden, Matthew A. B. Baker   +2 more
wiley   +1 more source

Phosphodiesterase inhibitors for the management of lower urinary tract symptoms in men without benign prostatic hyperplasia: a systematic review. [PDF]

Transl Androl Urol
Bakhsh A, Rajih E, Barayan GA, Garah E, Khan I, Alrehaili Z, Alhejaili S, Almuways M, Aloufi T, Alnazawi H, Alharbi A, Farghal D, Badawi A.   +12 more
europepmc   +1 more source

Phosphodiesterase Inhibitors for Pulmonary Hypertension [PDF]

New England Journal of Medicine, 2010
GALIE', NAZZARENO, Rubin LJ, Simonneau G.   +2 more
openaire   +1 more source

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

The Emerging Role of Phosphodiesterase Inhibitors in Fragile X Syndrome and Autism Spectrum Disorder. [PDF]

Pharmaceuticals (Basel)
Thomas SD, Mohammed HA, Hamad MIK, Oz M, Statsenko Y, Sadek B.   +5 more
europepmc   +1 more source

Cyclic AMP-hydrolyzing phosphodiesterase inhibitors potentiate statin-induced cancer cell death. [PDF]

Mol Oncol, 2020
Longo J, Pandyra AA, Stachura P, Minden MD, Schimmer AD, Penn LZ.   +5 more
europepmc   +1 more source

Potential Natural Product Phosphodiesterase Inhibitors

, 2013
Three different studies set forth to investigate the role of phosphodiesterase (PDE) enzyme inhibitors in sexual dysfunction and mood regulation. First, naturalproducts were screened by computer modeling of PDE5A1.
Cunningham, Michael John
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