Results 181 to 190 of about 53,329 (292)

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

The Construction and Application of a New Screening Method for Phosphodiesterase Inhibitors. [PDF]

Biosensors (Basel)
Gao C, Wang Z, Liu X, Sun R, Ma S, Ma Z, Wang Q, Li G, Zhang HT.   +8 more
europepmc   +1 more source

The effect of two phosphodiesterase inhibitors on bone healing in mandibular fractures (animal study in rats). [PDF]

J Korean Assoc Oral Maxillofac Surg, 2020
MalekiGorji M, Golestaneh A, Razavi SM.
europepmc   +1 more source

An age‐associated decline in the role of the sarcoplasmic reticulum and associated calcium‐handling proteins sets the pace for sinoatrial node function

The Journal of Physiology, EarlyView.
Abstract figure legend Stable, responsive pacemaking in the sinoatrial node is driven by the activity of the funny current (membrane clock), interplay of calcium cycling and release from the sarcoendoplasmic reticulum with depolarising sodium‐calcium exchange current (calcium clock). With increasing age, key proteins associated with calcium cycling are
Sandra A. Jones, Fiona S. Godbeer, Matthew K. Lancaster   +2 more
wiley   +1 more source

The use of phosphodiesterase inhibitors in the treatment of female sexual dysfunction: scoping review. [PDF]

Rev Bras Ginecol Obstet
Martins JCC, Lucas ARCA, Costa JMM.
europepmc   +1 more source

Differential Impact of Pharmacokinetic and Pharmacodynamic Variability on Response to Combination Therapy

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT Interindividual variability (IIV) in drug response complicates both fixed‐dose design and individualized therapy. Understanding how pharmacokinetic (PK) and pharmacodynamic (PD) processes jointly shape this variability is essential, particularly in combination therapy, where multiple interacting pathways influence outcomes. This study employed
Kuteesa R. Bisaso, Ronald Kadada Karyaburo, Jackson K. Mukonzo, Ene I. Ette   +3 more
wiley   +1 more source

Phosphodiesterase Inhibitors in Fetal Growth Restriction: Do Not Forget to Consider Fetal Sex and Subcellular Compartmentation. [PDF]

Biomedicines
Peyter AC, Baud D, Tolsa JF.
europepmc   +1 more source

The Role of Phosphodiesterase Inhibitors in the Management of Cavernositis With Multifocal Abscesses: A Report of Case Series. [PDF]

Sex Med, 2020
Bakhsh A, Daqqaq T, Alhasan A, Alnazari M, Rajih E.   +4 more
europepmc   +1 more source

Radiation dose optimization in coronary CT angiography clinical application of absolute phase gating in patients with atrial fibrillation

Journal of Applied Clinical Medical Physics, Volume 27, Issue 7, July 2026.
Abstract Background Atrial fibrillation (AF) poses significant challenges for coronary CT angiography (CCTA) due to R‐R interval variability, often necessitating high radiation dose protocols. Absolute phase gating, which uses fixed millisecond delays rather than percentage‐based cardiac cycle timing, may optimize image quality while reducing radiation
Yuyang Li
wiley   +1 more source

Phosphodiesterase inhibitors as adjunctive therapies for tuberculosis

EBioMedicine, 2016
Bintou Ahmadou Ahidjo, William R. Bishai
doaj   +1 more source