Results 221 to 230 of about 53,329 (292)

Phosphodiesterase Inhibitors as a Therapeutic Approach to Neuroprotection and Repair. [PDF]

Int J Mol Sci, 2017
Knott EP, Assi M, Rao SN, Ghosh M, Pearse DD.   +4 more
europepmc   +1 more source

SIRT1: Protean roles at the nexus of health, disease, and therapeutics

Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.
SIRT1 serves as a central regulator linking metabolism, stress responses, and disease. It influences diverse processes, including transcriptional and posttranscriptional gene expression and protein activity, inflammation, mitochondrial function, and cell survival, through the deacetylation of multiple protein targets. While SIRT1 often plays protective
Brahim Chaqour
wiley   +1 more source

Fetal sex and the relative reactivity of human umbilical vein and arteries are key determinants in potential beneficial effects of phosphodiesterase inhibitors.

J Appl Physiol (1985)
Peyter AC, Beaumann M, Delhaes F, Joye S, Menétrey S, Baud D, Tolsa JF.   +6 more
europepmc   +1 more source

Chemotherapeutic efficacy of phosphodiesterase inhibitors in chagasic cardiomyopathy. [PDF]

JACC Basic Transl Sci, 2016
Wen JJ, Wan X, Thacker J, Garg NJ.
europepmc   +1 more source

Structural‐to‐Functional Complexity Transformations Enabled by Bridged Polyheterocycles: Access to Cis‐1,3‐Diamines and Amino‐Alcohols

ChemistryEurope, Volume 4, Issue 6, June 2026.
Polycyclic intermediates enable stereocontrolled synthesis of densely functionalized cis‐1,3‐diamine and amino alcohol carbocycles and heterocycles via structural‐to‐functional complexity transformations from low‐complexity starting material. Cis‐1,3‐functionalized carbocycles and saturated heterocycles are ubiquitous motifs in natural products ...
Jiayi Zhu, Erica Benedetti, Laurent Micouin   +2 more
wiley   +1 more source

Phosphodiesterase inhibitors for lower urinary tract symptoms consistent with benign prostatic hyperplasia. [PDF]

Cochrane Database Syst Rev, 2018
Pattanaik S, Mavuduru RS, Panda A, Mathew JL, Agarwal MM, Hwang EC, Lyon JA, Singh SK, Mandal AK.   +8 more
europepmc   +1 more source

Survival Improvement With Steroid Use for Pulmonary Veno‐Occlusive Disease With the Aid of Pulmonary Vasodilators and Tyrosine‐Kinase Inhibitor, a Retrospective Study

Clinical Cardiology, Volume 49, Issue 6, June 2026.
This study aimed to assess the efficacy of steroid treatment with pulmonary vasodilators and tyrosine kinase inhibitors in patients with Pulmonary VenoOcclusive Disease (PVOD). Kaplan‐Meier curve showed that survival of PVOD patients with PSL (PRS) was significantly better with Log rank test (p = 0.01) than without PSL (PNS).
Mayumi Finger, Kaori Takeuchi, Hanako Kikuchi, Ayumi Goda, Takumi Inami, Yuichi Tamura, Masaharu Kataoka, Toru Satoh   +7 more
wiley   +1 more source

Evaluating the Intercropping Systems in the Context of Agroecological Resilience in the Current Era of the Changing Climate: A Scenario of Scientific Analysis of Last Decade Data

Climate Resilience and Sustainability, Volume 5, Issue 1, June 2026.
The extreme event of climate change (CC) has become more crucial, and under the current context of CC during the last decade. The cropping system (CS) approach is more appropriate than a suitable and established package of practices for individual crops, as CS interrelates with other components and resources related to sustainable farming under the ...
Sagar Maitra, Sumit Ray, Swati Suman, K. Pushpa, B. Sai Divya, Masina Sairam, Lalichetti Sagar, Harun I. Gitari, Santosh D. T., Akbar Hossain   +9 more
wiley   +1 more source

Pancreatic Islet Cell Crosstalk: Insight Into α‐/β‐Cell Compensatory Mechanisms

Comprehensive Physiology, Volume 16, Issue 3, June 2026.
α‐cell remodeling compensates for impaired β‐cell function. Intra‐islet glucagon/GLP‐1 signaling is upregulated and becomes essential in prediabetic islets. Flexible receptor engagement reflects functional plasticity in hormonal control of insulin secretion. Created in BioRender. Plecita, L. (2026); https://BioRender.com/pgjjg3m.
Štěpánka Benáková, Blanka Holendová, Jurij Dolenšek, Monika Křivonosková, Andraž Stožer, Lydie Plecitá‐Hlavatá   +5 more
wiley   +1 more source