Results 41 to 50 of about 623,776 (234)

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Effectiveness and safety of topical phosphodiesterase 4 inhibitors in children with mild-to-moderate atopic dermatitis: A systematic review and meta-analysis

Journal of International Medical Research
Objective To evaluate the efficacy and adverse effects of phosphodiesterase 4 inhibitors in children with mild-to-moderate atopic dermatitis. Methods Electronic searches were conducted based on PubMed, Cochrane Library, EMBASE, and Web of Science using ...
Long Wang, Lequ Zeng, Yuyu Wu, Min Zhong, Lizhen Zhang, Chen Li   +5 more
doaj   +1 more source

PDE1B and PDE10A as novel targets for schizophrenia: from molecular design and synthesis to therapeutic promise

Frontiers in Pharmacology
Phosphodiesterase 1B (PDE1B) and phosphodiesterase 10A (PDE10A), members of the phosphodiesterase superfamily, are responsible for cyclic nucleotide hydrolysis, thereby regulating key intracellular signaling pathways such as cAMP response element-binding
Jaya Rautela, Anand Gaurav, Anand Gaurav, Anand Gaurav, Veeranoot Nissapatorn, Veeranoot Nissapatorn, Chung Keat Tan, Ana Paula Girol, Ana Paula Girol, Maria De Lourdes Pereira, Maria De Lourdes Pereira, Vannajan Sanghiran Lee, Vannajan Sanghiran Lee   +12 more
doaj   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Phosphodiesterase 5 Inhibitors from Derris scandens

, 2018
Phosphodiesterase 5 inhibitors have been used as a first-line medicine for the treatment of erectile dysfunction. In the search for new phosphodiesterase 5 inhibitors from natural sources, we found that the 95% ethanol extract of Derris scandens stem ...
Yuthana Siriwattanasathien, Nitra Nuengchamnong, Nantaka Khorana, Pornnarin Taepavarapruk, Prompan Pitpakdeeanan, Kornkanok Ingkaninan, Apichart Suksamrarn, Nattiya Chaichamnong, Prapapan Temkitthawon   +8 more
core   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

The use of antimuscarinics, phosphodiesterase type V inhibitors and phytotherapy for lower urinary tract symptoms in men

Asian Journal of Urology, 2017
Besides the mainstay of α-blockers and 5α-reductase inhibitors, other forms of medical therapy complete the armamentarium in the treatment of lower urinary tract symptoms (LUTS) in men.
Kok Kit Ng, Foo Cheong Ng
doaj   +1 more source

Phosphodiesterase Type 5 Inhibitors and sudden sensorineural hearing loss [PDF]

, 2013
Phosphodiesterase type 5 Inhibitors, such as sildenafil, vardenafil and tadalafil have been increasingly used today and some of the users have developed sudden sensorineural hearing loss.ObjectiveTo present two patients with sudden deafness developed ...
Bahmad Jr,Fayez, Bahmad Júnior, Fayez, Barreto, Monique Antunes de Souza Chelminski, Bahmad, Fayez, Monique Antunes de Souza Chelminski Barreto, Barreto,Monique Antunes de Souza Chelminski, Fayez Bahmad Jr   +6 more
core   +1 more source

Ciliary Membrane Lipid Homeostasis in Health and Disease

Advanced Science, EarlyView.
This review systematically delineates the distinct lipid landscapes of ciliary membranes, including the spatial organization of phosphoinositides, cholesterol, and sphingolipids. It elucidates how these lipids orchestrate ciliogenesis, signal transduction, and membrane dynamics in cilia beating, and highlights how their dysregulation drives ...
Zhenzhou Huang, Yuan‐yuan Liu, Hanqi Sun, Peiwei Liu   +3 more
wiley   +1 more source

Membrane-Mediated Action of Phosphodiesterase 5 Inhibitors

Pharmaceutics
Background/Objectives: Phosphodiesterase 5 (PDE5) inhibitors, sildenafil, vardenafil, and tadalafil, activate the cyclic guanosine monophosphate pathway resulting in vascular smooth muscle relaxation.
Anna I. Malykhina, Svetlana S. Efimova, Olga S. Ostroumova   +2 more
doaj   +1 more source