Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels [PDF]
, 2007 Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independently ...
Millar, J.K. +14 more
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Phosphodiesterase Type 5 Inhibitors and Visual Side Effects: A Narrative Review
Journal of Ophthalmic & Vision Research, 2021 Phosphodiesterase type 5 inhibitors such as sildenafil citrate and tadalafil are well known for the treatment of erectile dysfunction. However, their use in the presence of pulmonary hypertension can cause ophthalmologic side effects, including non ...
Francisco Barroso +2 more
doaj +1 more source
Phosphodiesterase-5 inhibitors: Raynaud's and beyond
Indian Journal of Rheumatology, 2017 Phosphodiesterases (PDE) are a group of ubiquitously present enzymes involved in regulation of various cellular pathways. PDE5 acts to metabolize cyclic guanosine monophosphate (GMP).
Sanat Phatak +3 more
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PDE5 inhibitor drugs for use in dementia
Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 2023 Alzheimer's disease and related dementias (ADRD) remain a major health‐care challenge with few licensed medications. Repurposing existing drugs may afford prevention and treatment.
Atticus H. Hainsworth +4 more
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Pharmacotherapy of erectile dysfunction: Current standards
Indian Journal of Urology, 2006 Pharmacotherapy is currently the therapeutic option of choice for erectile dysfunction. Comprising mainly intracavernosal injection therapy using alprostadil or alprostadil combined with phentolamine and/or papaverine and oral phosphodiesterase-5 ...
Kew-Kim Chew
doaj +1 more source
Malaria parasite cGMP-dependent protein kinase regulates blood stage merozoite secretory organelle discharge and egress. [PDF]
, 2013 The malaria parasite replicates within an intraerythrocytic parasitophorous vacuole (PV). Eventually, in a tightly regulated process called egress, proteins of the PV and intracellular merozoite surface are modified by an essential parasite serine ...
Baker, David A +30 more
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A Review of phosphodiesterase-inhibition and the potential role for phosphodiesterase 4-inhibitors in clinical dermatology [PDF]
, 2014 Background: Phosphodiesterase inhibitors are commonly used drugs. Specific phosphodiesterase inhibitors with anti-inflammatory properties are being assessed as dermatological treatments.Purpose: To describe important aspects of phosphodiesterase ...
Moustafa, Farah, Feldman, Steven R
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Portopulmonary hypertension practice patterns after liver transplantation
Liver Transplantation, EarlyView., 2022 Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose +3 more
wiley +1 more source
Phosphonic acid-containing inhibitors of tyrosyl-DNA phosphodiesterase 1
Frontiers in Chemistry, 2022 Tyrosyl-DNA phosphodiesterase 1 (TDP1) repairs stalled type I topoisomerase (TOP1)-DNA complexes by hydrolyzing the phosphodiester bond between the TOP1 Y723 residue and the 3′-phosphate of its DNA substrate.
Xue Zhi Zhao +6 more
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Potential Roles of PDE4 Inhibitors in Peptic Ulcer Treatment
Клинический разбор в общей медицинеIntroduction. Peptic ulcer disease, a common gastrointestinal disorder, is mostly caused by Helicobacter pylori infection, non-steroidal anti-inflammatory drug usage, and lifestyle factors including alcohol use and smoking.
Khaled A. Abdel-Sater
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