Results 11 to 20 of about 623,776 (234)

Nonsteroidal anti-inflammatory drugs as potential ecto-nucleotide phosphodiesterase inhibitors

Brazilian Journal of Pharmaceutical Sciences, 2020
Phosphodiesterases (PDE) are group of enzymes which catalyze the hydrolysis of cAMP and cGMP. Since these cyclic phosphate moieties worked as intracellular second messengers in numerous physiological processes, their inhibition can affect normal ...
Shumaila Tasneem, Muhammad Saleem, Sheikh Arshad Saeed   +2 more
doaj   +3 more sources

Effect of phosphodiesterase inhibitors in the bladder [PDF]

Asian Journal of Urology, 2015
Many aging men will experience lower urinary tract symptoms (LUTS). Phosphodiesterase type 5 (PDE5) inhibitors have shown promise in treating LUTS in these patients.
Bilal Chughtai, Aizaz Ali, Claire Dunphy, Steven A. Kaplan   +3 more
doaj   +2 more sources

Phosphodiesterase type 5 inhibitors and erectile dysfunction

South African Family Practice, 2010
Erectile dysfunction (ED) affects millions of men globally and may adversely affect his, and potentially his partners’, quality of life. The introduction, a decade ago, of the phosphodiesterase type 5- (PDE5-) inhibitors has revolutionised the management
Catherine Whittaker
doaj   +2 more sources

A review of phosphodiesterase type 5 inhibitors [PDF]

South African Family Practice, 2014
Currently, three phosphodiesterase type 5 (PDE5) inhibitors are available for clinical use in South Africa; sildenafil, vardenafil and tadalafil. The PDE inhibitors are used in males to treat erectile dysfunction.
N. Schellack, A. Agoro
doaj   +4 more sources

Pathophysiology of visual disorders induced by phosphodiesterase inhibitors in the treatment of erectile dysfunction

Drug Design, Development and Therapy, 2016
Marilita M Moschos, Eirini Nitoda 1st Department of Ophthalmology, Medical School, National & Kapodistrian University of Athens, Athens, Greece Aim: The aim of this review was to summarize the ocular action of the most common phosphodiesterase (PDE)
Moschos MM, Nitoda E
doaj   +1 more source

The low KM-phosphodiesterase inhibitor denbufylline enhances neuronal excitability in guinea pig hippocampus in vitro [PDF]

, 1990
The actions of the phosphodiesterase inhibitor denbufylline on the excitability of hippocampal neurons were investigated by means of extracellular and intracellular recordings.
Ten Bruggencate, Gerrit, Sutor, Bernd, Ameri, A., Alzheimer, Christian   +3 more
core   +1 more source

The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice. [PDF]

, 2013
The specific inhibition of phosphodiesterase (PDE)4 and dual inhibition of PDE3 and PDE4 has been shown to decrease inflammation by suppression of pro-inflammatory cytokine synthesis.
Bundschuh Daniela S., Siegmund Britta, Bundschuh, D.S., Endres, S., Rieder, Florian, Lehr, Hans-Anton, Lehr, H.A., Endres Stefan, Siegmund, B., Stefan Endres, Eigler, A., Eigler Andreas, Bereswill, Stefan, Daniela S. Bundschuh, Rieder, F., Bundschuh, Daniela S., Eigler, Andreas, Rieder Florian, Florian Rieder, Britta Siegmund, Lehr Hans-Anton, Siegmund, Britta, Daniela S Bundschuh, Hans-Anton Lehr, Endres, Stefan, Andreas Eigler   +25 more
core   +1 more source

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. [PDF]

, 2015
Blocking Plasmodium falciparum transmission to mosquitoes has been designated a strategic objective in the global agenda of malaria elimination. Transmission is ensured by gametocyte-infected erythrocytes (GIE) that sequester in the bone marrow and at ...
Odile Mercereau-Puijalon, B. Naissant, F. Breil, Vernick Kenneth, Corbett Yolanda, Vernick, Kenneth D, Lavazec Catherine, Naissant Bernina, Duffier, Yoann, Naissant, Bernina, Eloise Thompson, Audrey Lorthiois (545164), Baker, David, A, Corbett, Yolanda, Duffier Yoann, Yolanda Corbett, Ghania Ramdani (676819), Vernick, Kenneth, Mercereau-Puijalon, Odile, Ramdani, Ghania, Yoann Duffier, Langsley Gordon, Ghania Ramdani, E. Thompson, Y. Corbett, K. Vernick, Audrey Lorthiois, Catherine Lavazec (106835), Dupuy, Florian, Gordon Langsley (85708), Gordon Langsley, Taramelli, Donatella, Baker, David ,, Florian Dupuy (616138), Lorthiois, Audrey, Bernina Naissant, Lavazec, Catherine, Dupuy Florian, Baker, David A, Catherine Lavazec, Odile Mercereau-Puijalon (58234), Mercereau-Puijalon Odile, David A Baker, Cummings Ross, Ross Cummings (736307), O. Mercereau Puijalon, Cummings, Ross, D. A. Baker, F. Dupuy, Florence Breil, Lorthiois Audrey, G. Langsley, Thompson Eloise, Y. Duffier, Florian Dupuy, Kenneth Vernick (736310), David A. Baker (122252), Baker, David,, A. Lorthiois, Breil Florence, Bernina Naissant (268019), R. Cummings, G. Ramdani, Yoann Duffier (736308), Donatella Taramelli, Ross Cummings, D. Taramelli, Ramdani Ghania, Taramelli Donatella, Langsley, Gordon, Baker David A., Kenneth Vernick, Thompson, Eloise, Florence Breil (736306), C. Lavazec, Eloise Thompson (376344), Yolanda Corbett (736309), Breil, Florence, Donatella Taramelli (736311)   +78 more
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Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels [PDF]

, 2007
Disrupted-in-schizophrenia 1 (DISC1) is a genetic susceptibility factor for schizophrenia and related severe psychiatric conditions. DISC1 is a multifunctional scaffold protein that is able to interact with several proteins, including the independently ...
Millar, J.K., Mackie, S., Houslay, M. D., Porteous, D.J., Hill, E. V., Hill, E.V., Porteous, D. J., Bolger, G.B., Murdoch, H., Klussmann, E., Collins, D. M., Millar, J. K., Bolger, G. B., Houslay, M.D., Collins, D.M.   +14 more
core   +1 more source

Phosphodiesterase Type 5 Inhibitors and Visual Side Effects: A Narrative Review

Journal of Ophthalmic & Vision Research, 2021
Phosphodiesterase type 5 inhibitors such as sildenafil citrate and tadalafil are well known for the treatment of erectile dysfunction. However, their use in the presence of pulmonary hypertension can cause ophthalmologic side effects, including non ...
Francisco Barroso, João Crispim Ribeiro, Eduardo P. Miranda   +2 more
doaj   +1 more source