Results 91 to 100 of about 45,588 (281)

PHARMACOTHERAPY IN PATIENTS WITH ERECTILE DYSFUNCTION AND BENIGN PROSTATIC HYPERPLASIA IN THE ABSENCE OF RISK OF DISEASE PROGRESSION

Исследования и практика в медицине, 2018
Purpose. Evaluation of the effectiveness and safety of various pharmacotherapy options in patients with erectile dysfunction (ED) in combination with benign prostatic hyperplasia (BPH).Materials and methods.
A. A. Kamalov, A. M. Tahirzade
doaj   +1 more source

Phosphodiesterase type 5 inhibitors and erectile dysfunction [PDF]

South African Family Practice, 2010
AbstractErectile dysfunction (ED) affects millions of men globally and may adversely affect his, and potentially his partners', quality of life. The introduction, a decade ago, of the phosphodiesterase type 5 (PDE5) inhibitors has revolutionised the management of ED.
openaire   +1 more source

Walsh & Hoyt: Sildenafil [PDF]

, 2005
Sildenafil citrate (Viagra, Pfizer Pharmaceuticals, New York, NY) is a phosphodiesterase type 5 inhibitor that is prescribed for erectile ...
Paul H. Phillips, MD
core  

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Insulin-like effect of the phosphodiesterase type 5 inhibitor tadalafil onto male human skeletal muscle cells [PDF]

, 2013
Background: Phosphodiesterase type 5 inhibitors (PDE5i), widely used to treat male erectile dysfunction, seem to counteract insulin resistance (IR) in animals and humans.
L. Di Luigi, LENZI, Andrea, N. Sturli, P. Bonini, M. Sottili, C. Crescioli   +5 more
core   +3 more sources

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Clinical Efficacy and Safety of Topical Roflumilast in Psoriasis: An Updated Systematic Review and Meta‐Analysis of Randomized Controlled Trials

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Traditional first‐line topical treatments for plaque psoriasis, particularly corticosteroids and vitamin D analogs, frequently have only limited efficacy for long‐term use, and present difficulties with safety and adherence. Objectives In this systematic review and meta‐analysis of randomized controlled trials (RCTs), we assessed ...
Aimal A. Khattak, Ahmed Javed, Ummi Aiman Rahman, Rumaisa Riaz, Zeeshan Imtiaz, Hassan A. Mirza, Farman U. Khan, Muhid Khattak, Fatima Javid, Abdul Moiz Khan, Adeline L. Roy, Bibek Shrestha   +11 more
wiley   +1 more source

Predictors of Phosphodiesterase Type 5 Inhibitor Treatment Failure in Patients Diagnosed With Erectile Dysfunction. [PDF]

Cureus, 2023
Albarakati M, El-Tholoth HS, Alzahrani A, Alghamdi OS, Alquliti A, Alnuami M, Althobity A, Almardawi A, Bedaiwi K.   +8 more
europepmc   +1 more source

Diabetic nephropathy: Treatment with phosphodiesterase type 5 inhibitors

World Journal of Diabetes, 2013
The importance of nitric oxide (NO) in vascular physiology is irrefutable; it stimulates the intracellular production of cyclic guanosine monophosphate (cGMP), initiating vascular smooth muscle relaxation. This biochemical process increases the diameter of small arteries, regulating blood flow distribution between arterioles and the microvasculature ...
openaire   +2 more sources

Protective Effects of Riociguat Against Contrast‐Induced Nephropathy: An Experimental and Machine Learning‐Based Study in Rats

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Contrast‐induced nephropathy (CIN) is an important cause of acute kidney injury following exposure to iodinated contrast media, and effective preventive strategies remain limited. This study investigated the renoprotective effects of riociguat, a soluble guanylate cyclase stimulator, in an experimental rat model of CIN and explored machine ...
Mustafa Begenc Tascanov, Kenan Toprak, Sibel Turedi, İsmail Koyuncu, Zulkif Tanrıverdi, Necip Fazıl Dedeoglu, Halil Fedai, Asuman Bicer, İbrahim Halil Altıparmak, Recep Demirbag, Gencay Sarıısık   +10 more
wiley   +1 more source