Results 101 to 110 of about 45,588 (281)

Acute effect of phosphodiesterase type 5 inhibitor on serum oxidative status and prolidase activities in men with erectile dysfunction

Clinics, 2010
OBJECTIVES: To investigate the acute effect of phosphodiesterase type 5 (PDE5) inhibitor on erectile dysfunction by evaluating serum oxidative status and prolidase activity.
Murat Savas, Ercan Yeni, Ayhan Verit, Mehmet Gulum, Nurten Aksoy, Halil Ciftci, Hakim Celik, Adem Altunkol, Halil Oncel   +8 more
doaj   +1 more source

A Cost Analysis of Phosphodiesterase Type 5 Inhibitors in the United States [PDF]

Urology
To perform a cost analysis of generic and brand-name Phosphodiesterase Type 5 (PDE5) inhibitors at different dosages and pharmacies across the US.Using an all-payer retail pharmacy-claims database, we analyzed prescription drug data for three generic and six brand-name oral PDE5 inhibitors at different dosages across US chain and independent pharmacies
Behnam Nabavizadeh, Amanda Nguyen, Diane Li, Jeroen van Meijgaard, Benjamin N. Breyer   +4 more
openaire   +3 more sources

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

CLINICAL CASE: COMBINATION THERAPY WITH BOSENTAN AND SILDENAFIL IN THE TREATMENT OF IDIOPATHIC PULMONARY HYPERTENSION

Евразийский Кардиологический Журнал, 2014
The patient with the verified diagnosis of idiopathic pulmonary hypertension, functional class III (WHO) was treated by anticoagulants, diuretics, calcium channel blocker. After one year of adding endothelin receptor antagonist bosentan there was noticed
V. V. Bystrov, O. A. Arkhipova, T. V. Martynyuk, M. A. Saidova, O. V. Stukalova, N. M. Danilov, T. A. Sakhnova, I. Ye. Chazova   +7 more
doaj   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

Changes in Left Ventricular Ejection Fraction and Oxidative Stress after Phosphodiesterase Type-5 Inhibitor Treatment in an Experimental Model of Retrograde Rat Perfusion. [PDF]

Medicina (Kaunas), 2023
Krivokapic M, Alisultanovich Omarov I, Zivkovic V, Nikolic Turnic T, Jakovljevic V.   +4 more
europepmc   +1 more source

AB030. Evolution of phosphodiesterase type 5 inhibitors

Translational Andrology and Urology, 2016
After launching of sildenafil citrate, the last invention of 20(th) century, in 1998, oral phosphodiesterase type 5 (PDE5) inhibitor has been established as first line treatment of erectile dysfunction and shift new paradigm of diagnosis and treatment of erectile dysfunction.
openaire   +2 more sources

Phosphodiesterase type 5 inhibitors: a biochemical and clinical correlation survey [PDF]

International Journal of Impotence Research, 2003
Phosphodiesterase type 5 (PDE 5) is the major cGMP hydrolyzing enzyme in penile corpus cavernosum and is an important regulator of nitric oxide-mediated smooth muscle relaxation. The critical role of PDE 5 in penile erection and the recent availability of specific and potent inhibitors of PDE 5 have enabled the development of effective oral treatment ...
openaire   +2 more sources

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Phosphodiesterase Inhibitory Activity of the Flavonoids and Xanthones from

Natural Product Communications, 2015
Five flavonoids, one isoflavone and five xanthones were isolated from Anaxagorea luzonensis . Of these eleven isolated compounds, 1,3,5-trihydroxy-4-prenylxanthone ( 3 ) was a relatively potent inhibitor of phosphodiesterase type 5 (PDE5), with an IC 50 ...
Chalisa Sabphon, Prapapan Temkitthawon, Kornkanok Ingkaninan, Pattara Sawasdee   +3 more
doaj   +1 more source