Results 121 to 130 of about 17,985,271 (268)

Positive outcomes of phosphodiesterase type 5 inhibitor on histopathologic and biochemical changes induced by ureteral obstruction

, 2019
OBJECTIVES: We examined the effects of tadalafil, one of the phosphodiesterase type 5 (PDE5) inhibitors, in a rat model of with partial and complete unilateral ureteral obstruction (UUO)
Cetinkol, Yeliz, Cirrik, Selma, Noyan, Tevfik, Benli, Erdal, Ayyildiz, Ali, Kokturk, Sibel, Ayyildiz, Sema Nur   +6 more
core   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Boronic Acid Inhibitors of β‐Lactamases: A Promising Strategy Against Antimicrobial Resistance

Medicinal Research Reviews, EarlyView.
ABSTRACT The rise of antimicrobial resistance (AMR) poses a critical threat to global health, mostly due to the proliferation of β‐lactamases, a class of enzymes responsible for the inactivation of β‐lactam antibiotics. Among the most promising strategies to restore β‐lactam efficacy is the use of β‐lactamase inhibitors (BLIs), with boronic acid ...
Nicolò Santi, Federico Corsini, Robert A. Bonomo, Emilia Caselli, Fabio Prati   +4 more
wiley   +1 more source

The Benefits of Adding Non‐Antimuscarinic Pharmaceuticals in Combination With Beta‐3 Agonists for Overactive Bladder Treatment: A Systematic Review

Neurourology and Urodynamics, EarlyView.
ABSTRACT Introduction Antimuscarinics, as the current first‐line pharmacologic therapies for overactive bladder, exhibit low patient adherence and high rates of reported side effects. As a modern alternative pharmaceutical treatment, beta‐3 agonists, which relax the urinary bladder, may be more tolerable for patients, increasing adherence and ...
Felicity Smith, Charlotte Phelps, Christian Moro   +2 more
wiley   +1 more source

Sodium Ions Affect GPR17 Conformational States and Functionality

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Sodium is an allosteric modulator of several class‐A GPCR regulating active versus inactive conformation state and may be a critical issue for the optimization of crystallization procedures. Herein, the role of Na+ in the regulation of GPR17 conformational states was studied through MD simulations of GPR17 wild‐type and mutated on two ...
Luca Palazzolo, Simona Daniele, Davide Bianchi, Lara Russo, Stefano Capaldi, Maria Letizia Trincavelli, Ivano Eberini   +6 more
wiley   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Efficacy and safety of endothelin receptor antagonists, phosphodiesterase type 5 Inhibitors, and prostaglandins in pediatric pulmonary arterial hypertension: A network meta-analysis. [PDF]

Front Cardiovasc Med, 2022
Cao F, Wu K, Zhu YZ, Jiang JJ, Zhang G, Liu J, Xiao P, Tian Y, Zhang W, Zhang S, Hou F, Bao ZW.   +11 more
europepmc   +1 more source

Key Features for Designing Phosphodiesterase-5 Inhibitors

, 2012
[[abstract]]"Phosphodiesterase superfamily is the key regulator of 3′,5′-cyclic guanosine monophosphate (cGMP) decomposition in human body. Phosphodiesterase-5 (PDE-5) inhibitors, sildenafil, vardenafil and tadalafil, are well known oral treatment for ...
;Chang, Tung-Ti;Huang, Hung-Jin;李桂仁;Lee, Kuei-Jen;Yu, Hsin Wei;Chen, Hsin-Yi;蔡輔仁;Tsai, Fuu-Jen;Sun, Mao-Feng;陳語謙;Chen, Calvin Yu-Chian
core  

Oral Phosphodiesterase Type 5 Inhibitors Alleviate Recurrent Priapism Complicating Thalassemia Intermedia: A Case Report

, 2009
Introduction. Recurrent ischemic priapism still remains a serious and difficult to treat complication of certain hematological disorders. Elucidation of the underlying pathophysiologic mechanisms and application of new effective prophylactic treatments ...
Mamoulakis, Charalampos, Kyriakou, Despina, Gravas, Stavros, Meissner, A., Tzortzis, V., Melekos, M. D., Tzortzis, Vassilios, Meissner, Andreas, Mitrakas, L., Kyriakou, D., Mitrakas, Lampros, Gravas, S., Mamoulakis, C., Melekos, Michael D.   +13 more
core   +1 more source

Inhaled Corticosteroid Escalation After a Single Moderate Exacerbation in COPD: Differential Benefit by Exacerbation Subtype

Respirology, EarlyView.
We tested whether ICS escalation after a single moderate COPD exacerbation improved outcomes according to exacerbation treatment phenotype. ICS reduced future exacerbations only in steroid‐treated events, not antibiotic‐treated events. This study supports phenotype‐guided escalation after one moderate exacerbation, avoiding overtreatment with precise ...
Sun Hye Shin, Jihye Heo, Ji Ye Jung, Juhee Cho, Dave Singh, Danbee Kang, Hye Yun Park   +6 more
wiley   +1 more source