TcALS knockdown accelerates metamorphosis via insulin signaling in Tribolium castaneum
Insect Science, EarlyView.RNAi silencing of TcALS accelerates larva‐to‐pupa metamorphosis in Tribolium castaneum. Abstract Insect metamorphosis is an evolutionary adaptation precisely regulated by nutritional and hormonal cues. The red flour beetle Tribolium castaneum, a major stored‐product pest, serves as an excellent model for studying this process.
Min Li +8 more
wiley +1 more source
Calmodulin in Complex with Proteins and Small Molecule Ligands: Operating with the Element of Surprise. Implications for Structure-Based Drug Design [PDF]
, 2009 Calmodulin plays a role in several life processes, its flexibility allows binding of a number of different ligands from small molecules to amphiphilic peptide helices and proteins. Through the diversity of its functions, it is quite difficult to find new
Keserű, György Miklós +2 more
core
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Are phosphodiesterase Type 5 inhibitors potential therapies for Alzheimer's disease and related dementias? [PDF]
Brain Commun, 2022 Newby D.
europepmc +1 more source
Andrology, EarlyView.Abstract Objective We aimed to investigate the association of a low serum testosterone concentration with the risk of abnormal glucose metabolism (i.e., prediabetes and type 2 diabetes) in men at a 15‐year follow‐up. Study population and methods In a population birth cohort, men with low testosterone (testosterone < 12.1 nmol/L, n = 136) and normal ...
Tuomisto A +7 more
wiley +1 more source
Combination vardenifil and tadalifil drug induced liver injury; case report and review of the literature of liver injury associated with phosphodiesterase type 5 inhibitors. [PDF]
Can Liver J, 2023 Xu B, Braxton DR, Fong TL.
europepmc +1 more source
Andrology, EarlyView.ABSTRACT Background Peyronie's disease (PD) with severe penile curvature often requires surgical correction through plaque incision and grafting (PIG). Objectives To compare surgical outcomes between polyglycolic acid polymer grafts and porcine small intestinal submucosa (SIS) grafts in patients undergoing PIG for PD.
Renan Trevisan Jost +7 more
wiley +1 more source
Safety profile and signal detection of phosphodiesterase type 5 inhibitors for erectile dysfunction: a Food and Drug Administration Adverse Event Reporting System analysis. [PDF]
Sex Med, 2023 Shin YE +3 more
europepmc +1 more source
SIEDY Diagnostic Accuracy in Assessing Erectile Dysfunction in Young Men Living With HIV
Andrology, EarlyView.ABSTRACT Background Erectile dysfunction (ED) is a multidimensional condition commonly affecting men living with HIV. The structured interview of erectile dysfunction (SIEDY) is the only validated tool assessing organic, relational, and psychological factors contributing to ED, while dynamic penile color Doppler ultrasound (dPCDU) is a reliable method ...
Giorgio Tiecco +10 more
wiley +1 more source