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Phosphodiesterase Type 5 Inhibitors, Sport and Doping [PDF]

open access: yesCurrent Sports Medicine Reports, 2017
Phosphodiesterase type 5 inhibitors (PDE5i) (e.g., sildenafil, tadalafil, vardenafil, and avanafil) are drugs commonly used to treat erectile dysfunction, pulmonary arterial hypertension, and benign prostatic hyperplasia.
Borrione, Paolo   +8 more
core   +5 more sources

A review of phosphodiesterase type 5 inhibitors [PDF]

open access: yesSouth African Family Practice, 2014
Currently, three phosphodiesterase type 5 (PDE5) inhibitors are available for clinical use in South Africa; sildenafil, vardenafil and tadalafil. The PDE inhibitors are used in males to treat erectile dysfunction.
N. Schellack, A. Agoro
doaj   +3 more sources

Phosphodiesterase type 5 inhibitors and erectile dysfunction [PDF]

open access: yesSouth African Family Practice, 2010
Erectile dysfunction (ED) affects millions of men globally and may adversely affect his, and potentially his partners’, quality of life. The introduction, a decade ago, of the phosphodiesterase type 5- (PDE5-) inhibitors has revolutionised the management
Catherine Whittaker
doaj   +2 more sources

A role for phosphodiesterase type 5 inhibitors in remodelling the urinary bladder after radiation exposure. [PDF]

open access: yesPLoS ONE, 2020
Minimizing the toxicity of radiotherapy is challenging. We investigated the effects of a phosphodiesterase type-5 inhibitor (PDE5I) on the urinary bladder after pelvic radiotherapy.
Hee Youn Kim, Dong Sup Lee
doaj   +2 more sources

Rapid Screening and Quantitative Determination of Illegal Phosphodiesterase Type 5 Inhibitors (PDE-5i) in Herbal Dietary Supplements [PDF]

open access: yesJournal of Analytical Methods in Chemistry, 2021
Phosphodiesterase type 5 inhibitors (PDE-5i) are the first-line medication for oral erectile dysfunction, which are used according to the prescription of doctors. However, these substances have been found illegally in supplementary foods. The quality and
Thi Oanh Nguyen   +10 more
doaj   +2 more sources

Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling [PDF]

open access: yesFrontiers in Oncology, 2020
Combination therapies that display cancer-killing activities through either coexistent targeting of several cellular factors or more efficient suppression of a specific pathway are generally used in cancer treatment.
Jui-Ling Hsu   +7 more
doaj   +2 more sources

Efficacy of phosphodiesterase type 5 inhibitors in univentricular congenital heart disease: the SV‐INHIBITION study design [PDF]

open access: yesESC Heart Failure, 2020
Aims In univentricular hearts, selective lung vasodilators such as phosphodiesterase type 5 (PDE5) inhibitors would decrease pulmonary resistance and improve exercise tolerance.
Pascal Amedro   +18 more
doaj   +2 more sources

Phosphodiesterase Type 5 Inhibitors and Risk of Skin Cancers in Men: A Meta-Analysis and Trial Sequential Analysis Involving 7,479,852 Subjects [PDF]

open access: yesThe World Journal of Men's Health, 2021
Purpose: We conducted a systematic review and meta-analysis to quantify the association between phosphodiesterase type 5 inhibitors (PDE5Is) use and skin cancers and we also examined whether down-expression of the PDE5A gene was related to worse ...
Yi Patrick. Lu   +9 more
doaj   +2 more sources

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