Results 21 to 30 of about 38,631 (238)

Phosphodiesterase Type 5 Inhibitors, Sport and Doping [PDF]

Current Sports Medicine Reports, 2017
Phosphodiesterase type 5 inhibitors (PDE5i) (e.g.,sildenafil, tadalafil, vardenafil, and avanafil) are drugs commonly used to treat erectile dysfunction, pulmonary arterial hypertension, and benign prostatic hyperplasia. PDE5i are not prohibited by the World Anti-Doping Agency (WADA) but are alleged to be frequently misused by healthy athletes to ...
Di Luigi, Luigi, Sansone, Massimiliano, Sansone, Andrea, CECI GALANOS, ROBERTA, Duranti, Guglielmo, Borrione, Paolo, Crescioli, Clara, Sgrò, Paolo, Sabatini, Stefania   +8 more
openaire   +4 more sources

Cardiovascular Effects of Phosphodiesterase Type 5 Inhibitors

The Journal of Sexual Medicine, 2009
ABSTRACT Introduction Phosphodiesterase type 5 (PDE5) inhibitors are widely used as first-line therapy for erectile dysfunction (ED). Their efficacy and safety combined with an increasing understanding of cyclic guanosine monophosphate (cGMP)-regulated mechanisms have triggered a number of attempts to
Charalambos, Vlachopoulos, Nikolaos, Ioakeimidis, Konstantinos, Rokkas, Christodoulos, Stefanadis   +3 more
openaire   +4 more sources

Phosphodiesterase Inhibitors: Present and Future

Barcelona Respiratory Network Reviews, 2023
Phosphodiesterase (PDE) inhibitors act on specific phosphodiesterase enzymes (fundamentally 3, 4 and 5), which are characterized by their expression in different organs.
José L. Izquierdo-Alonso
doaj   +1 more source

COVID-19 and phosphodiesterase enzyme type 5 inhibitors

Journal of Microscopy and Ultrastructure, 2020
COVID-19 pathology is mainly associated to a pulmonary disease which sometimes might result in an uncontrollable storm related to inflammatory diseases which could be fatal. It is well known that phosphodiesterase enzyme type 5 inhibitors (PDE5Is), such as sildenafil, have been successfully developed for the treatment of pulmonary arterial hypertension;
Al-Kuraishy, Hayder M., Al-Gareeb, Ali I., Al-Niemi, Marwa S., Al-Buhadily, Ali K., Al-Harchan, Nasser A., Lugnier, Claire   +5 more
openaire   +3 more sources

Why humans need type 5 phosphodiesterase inhibitors [PDF]

International Journal of Andrology, 2005
SummaryErectile dysfunction (ED) is a widespread medical condition affecting millions of males at any age and requiring medical treatment. ED may simply reflect a limit of human physiology, yet ED equates to genetic death and the high prevalence of ED is a clear evolutionary paradox.
CELLERINO, Alessandro, JANNINI E. A.
openaire   +3 more sources

Therapeutic benefits of Phosphodiesterase type 5 inhibitors: A comprehensive review [PDF]

Archives of Pharmaceutical Sciences Ain Shams University
Phosphodiesterase type 5 (PDE5) inhibitors have been widely used to treat erectile dysfunction. This review aims to explore the favorable effects of PDE5 inhibitors in clinical applications beyond their conventional use.
Yasmin Nabil, Yara M. Aboelmagd, Christine Nathan Habib, ٍamar S. Azab   +3 more
doaj   +1 more source

Phosphodiesterase type 5 Inhibitors (PDE-5I) as a potential therapeutic drug in stroke: A systematic narrative review [PDF]

Romanian Journal of Neurology, 2023
Objectives. Stroke is an acute cerebrovascular disease with high morbidity and mortality rate. Many stroke management strategies can improve prognosis and quality of life, but only to a certain extent.
Harvey Sudharta, Fani Agusta Chandra, Nadya Novemia, Andre, Jimmy Fransisco Abadinta Barus, Poppy Kristina Sasmita   +5 more
doaj   +1 more source

Erectile dysfunction in diabetes mellitus: A review

Journal of Diabetology, 2020
The International Diabetes Federation estimates that globally there are 425 million people with diabetes. Estimates of the prevalence of erectile dysfunction (ED) in men with diabetes range from 20% to 85% in different studies.
Deepak K Jumani, Omkar Patil
doaj   +1 more source

Phosphodiesterase Type-5 Inhibitor and Oxidative Stress

International Journal of Immunopathology and Pharmacology, 2008
Erectile dysfunction (ED) is a common medical condition that affects the sexual life of millions of men worldwide. Numerous physical and psychological factors are involved in normal erectile function, including neurological, vascular, hormonal and cavernous functions.
SPERANZA, Lorenza, FRANCESCHELLI, SARA, PESCE, MIRKO, VINCIGUERRA, ISABELLA, DE LUTIIS, Maria Anna, GRILLI, Alfredo, FELACO, Mario, PATRUNO, ANTONIA   +7 more
openaire   +3 more sources

Portopulmonary hypertension practice patterns after liver transplantation

Liver Transplantation, EarlyView., 2022
Abstract Portopulmonary hypertension (POPH) is a type of pulmonary arterial hypertension occurring exclusively in those with portal hypertensive liver disease. Liver transplantation (LT) can significantly improve outcomes. Current guidelines counsel against immediate adjustments to targeted therapy after LT and suggest routine echocardiography as ...
Arun Jose, Elizabeth J. Kopras, Shimul A. Shah, Jean M. Elwing   +3 more
wiley   +1 more source