Results 21 to 30 of about 17,985,271 (268)

Efficacy of phosphodiesterase type 5 inhibitors in univentricular congenital heart disease: the SV‐INHIBITION study design [PDF]

ESC Heart Failure, 2020
Aims In univentricular hearts, selective lung vasodilators such as phosphodiesterase type 5 (PDE5) inhibitors would decrease pulmonary resistance and improve exercise tolerance.
Pascal Amedro, Arthur Gavotto, Hamouda Abassi, Marie‐Christine Picot, Stefan Matecki, Sophie Malekzadeh‐Milani, Marilyne Levy, Magalie Ladouceur, Caroline Ovaert, Philippe Aldebert, Jean‐Benoit Thambo, Alain Fraisse, Marc Humbert, Sarah Cohen, Alban‐Elouen Baruteau, Clement Karsenty, Damien Bonnet, Sebastien Hascoet, SV‐INHIBITION study investigators   +18 more
doaj   +2 more sources

Phosphodiesterase Type 5 Inhibitors and Risk of Skin Cancers in Men: A Meta-Analysis and Trial Sequential Analysis Involving 7,479,852 Subjects [PDF]

The World Journal of Men's Health, 2021
Purpose: We conducted a systematic review and meta-analysis to quantify the association between phosphodiesterase type 5 inhibitors (PDE5Is) use and skin cancers and we also examined whether down-expression of the PDE5A gene was related to worse ...
Yi Patrick. Lu, Shujun Fan, Zhen Liang, Yuxuan Song, Kang Liu, Kechong Zhou, Xiao Wang, Jiaqi Kang, Yongjiao Yang, Xiaoqiang Liu   +9 more
doaj   +2 more sources

Evolution of phosphodiesterase type 5 inhibitors in treatment of erectile dysfunction in Taiwan [PDF]

Urological Science, 2016
Erectile dysfunction (ED) is a prevalent form of male sexual dysfunction. Phosphodiesterase type 5 (PDE5) inhibitor is the first-line treatment for ED. Numerous well-designed and -conducted clinical trials and postmarketing studies have established the ...
Bang-Ping Jiann
doaj   +2 more sources

Phosphodiesterase Type 5 Inhibitors and COVID-19: Are They Useful In Disease Management? [PDF]

The World Journal of Men's Health, 2020
Nicola Mondaini
doaj   +2 more sources

AB030. Evolution of phosphodiesterase type 5 inhibitors [PDF]

Transl Androl Urol, 2016
After launching of sildenafil citrate, the last invention of 20(th) century, in 1998, oral phosphodiesterase type 5 (PDE5) inhibitor has been established as first line treatment of erectile dysfunction and shift new paradigm of diagnosis and treatment of erectile dysfunction.
europepmc   +3 more sources

Safety and Effectiveness of Repeated Botulinum Toxin A Intracavernosal Injections in Men with Erectile Dysfunction Unresponsive to Approved Pharmacological Treatments: Real-World Observational Data

Toxins, 2023
Intracavernosal injections of botulinum toxin A (BTX/A ic) may be effective for difficult-to-treat erectile dysfunction (ED). This is a retrospective case series study of the effectiveness of repeated off-label BTX/A ic (onabotulinumtoxinA 100U ...
François Giuliano, Pierre Denys, Charles Joussain   +2 more
doaj   +1 more source

The selective phosphodiesterase 4 inhibitor roflumilast and phosphodiesterase 3/4 inhibitor pumafentrine reduce clinical score and TNF expression in experimental colitis in mice. [PDF]

, 2013
The specific inhibition of phosphodiesterase (PDE)4 and dual inhibition of PDE3 and PDE4 has been shown to decrease inflammation by suppression of pro-inflammatory cytokine synthesis.
Bundschuh Daniela S., Siegmund Britta, Bundschuh, D.S., Endres, S., Rieder, Florian, Lehr, Hans-Anton, Lehr, H.A., Endres Stefan, Siegmund, B., Stefan Endres, Eigler, A., Eigler Andreas, Bereswill, Stefan, Daniela S. Bundschuh, Rieder, F., Bundschuh, Daniela S., Eigler, Andreas, Rieder Florian, Florian Rieder, Britta Siegmund, Lehr Hans-Anton, Siegmund, Britta, Daniela S Bundschuh, Hans-Anton Lehr, Endres, Stefan, Andreas Eigler   +25 more
core   +1 more source

cAMP-Signalling Regulates Gametocyte-Infected Erythrocyte Deformability Required for Malaria Parasite Transmission. [PDF]

, 2015
Blocking Plasmodium falciparum transmission to mosquitoes has been designated a strategic objective in the global agenda of malaria elimination. Transmission is ensured by gametocyte-infected erythrocytes (GIE) that sequester in the bone marrow and at ...
Odile Mercereau-Puijalon, B. Naissant, F. Breil, Vernick Kenneth, Corbett Yolanda, Vernick, Kenneth D, Lavazec Catherine, Naissant Bernina, Duffier, Yoann, Naissant, Bernina, Eloise Thompson, Audrey Lorthiois (545164), Baker, David, A, Corbett, Yolanda, Duffier Yoann, Yolanda Corbett, Ghania Ramdani (676819), Vernick, Kenneth, Mercereau-Puijalon, Odile, Ramdani, Ghania, Yoann Duffier, Langsley Gordon, Ghania Ramdani, E. Thompson, Y. Corbett, K. Vernick, Audrey Lorthiois, Catherine Lavazec (106835), Dupuy, Florian, Gordon Langsley (85708), Gordon Langsley, Taramelli, Donatella, Baker, David ,, Florian Dupuy (616138), Lorthiois, Audrey, Bernina Naissant, Lavazec, Catherine, Dupuy Florian, Baker, David A, Catherine Lavazec, Odile Mercereau-Puijalon (58234), Mercereau-Puijalon Odile, David A Baker, Cummings Ross, Ross Cummings (736307), O. Mercereau Puijalon, Cummings, Ross, D. A. Baker, F. Dupuy, Florence Breil, Lorthiois Audrey, G. Langsley, Thompson Eloise, Y. Duffier, Florian Dupuy, Kenneth Vernick (736310), David A. Baker (122252), Baker, David,, A. Lorthiois, Breil Florence, Bernina Naissant (268019), R. Cummings, G. Ramdani, Yoann Duffier (736308), Donatella Taramelli, Ross Cummings, D. Taramelli, Ramdani Ghania, Taramelli Donatella, Langsley, Gordon, Baker David A., Kenneth Vernick, Thompson, Eloise, Florence Breil (736306), C. Lavazec, Eloise Thompson (376344), Yolanda Corbett (736309), Breil, Florence, Donatella Taramelli (736311)   +78 more
core   +1 more source

COVID-19 and phosphodiesterase enzyme type 5 inhibitors

Journal of Microscopy and Ultrastructure, 2020
COVID-19 pathology is mainly associated to a pulmonary disease which sometimes might result in an uncontrollable storm related to inflammatory diseases which could be fatal. It is well known that phosphodiesterase enzyme type 5 inhibitors (PDE5Is), such as sildenafil, have been successfully developed for the treatment of pulmonary arterial hypertension;
Al-Kuraishy, Hayder M., Al-Gareeb, Ali I., Al-Niemi, Marwa S., Al-Buhadily, Ali K., Al-Harchan, Nasser A., Lugnier, Claire   +5 more
openaire   +3 more sources

Why humans need type 5 phosphodiesterase inhibitors [PDF]

International Journal of Andrology, 2005
SummaryErectile dysfunction (ED) is a widespread medical condition affecting millions of males at any age and requiring medical treatment. ED may simply reflect a limit of human physiology, yet ED equates to genetic death and the high prevalence of ED is a clear evolutionary paradox.
CELLERINO, Alessandro, JANNINI E. A.
openaire   +3 more sources