Cardiovascular Effects of Phosphodiesterase Type 5 Inhibitors
The Journal of Sexual Medicine, 2009 ABSTRACT Introduction Phosphodiesterase type 5 (PDE5) inhibitors are widely used as first-line therapy for erectile dysfunction (ED). Their efficacy and safety combined with an increasing understanding of cyclic guanosine monophosphate (cGMP)-regulated mechanisms have triggered a number of attempts to
Charalambos, Vlachopoulos +3 more
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Phosphodiesterase Type 5 Inhibitors, Sport and Doping [PDF]
Current Sports Medicine Reports, 2017 Phosphodiesterase type 5 inhibitors (PDE5i) (e.g.,sildenafil, tadalafil, vardenafil, and avanafil) are drugs commonly used to treat erectile dysfunction, pulmonary arterial hypertension, and benign prostatic hyperplasia. PDE5i are not prohibited by the World Anti-Doping Agency (WADA) but are alleged to be frequently misused by healthy athletes to ...
Di Luigi, Luigi +8 more
openaire +6 more sources
Phosphodiesterase Inhibitors: Present and Future
Barcelona Respiratory Network Reviews, 2023 Phosphodiesterase (PDE) inhibitors act on specific phosphodiesterase enzymes (fundamentally 3, 4 and 5), which are characterized by their expression in different organs.
José L. Izquierdo-Alonso
doaj +2 more sources
The Effect of Phosphodiesterase-type 5 Inhibitors on Erectile Function: An Overview of Systematic Reviews [PDF]
Frontiers in Pharmacology, 2021 Background: Multiple systematic reviews explore the effect of phosphodiesterase type 5 (PDE5) inhibitors on erectile dysfunction (ED), with each study addressing specific outcomes.
Nikolaos Pyrgidis +12 more
doaj +2 more sources
Phosphodiesterase Type 5 Inhibitors in Male Reproduction: Molecular Mechanisms and Clinical Implications for Fertility Management [PDF]
CellsPhosphodiesterases, particularly the type 5 isoform (PDE5), have gained recognition as pivotal regulators of male reproductive physiology, exerting significant influence on testicular function, sperm maturation, and overall fertility potential.
Aris Kaltsas +4 more
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Phosphodiesterase type 5 inhibitors as treatment for erectile dysfunction: a webinar-based poll unveiling perceptions of healthcare professionals [PDF]
Journal of Comparative Effectiveness ResearchAim: Erectile dysfunction (ED) is marked by a recurring incapacity to achieve or uphold a satisfactory erection during sexual activities. The study aims to increase awareness about male reproductive health, dispel misconceptions about ED and encourage ...
Maher S Moazin +10 more
doaj +2 more sources
A role for phosphodiesterase type 5 inhibitors in remodelling the urinary bladder after radiation exposure. [PDF]
PLoS ONE, 2020 Minimizing the toxicity of radiotherapy is challenging. We investigated the effects of a phosphodiesterase type-5 inhibitor (PDE5I) on the urinary bladder after pelvic radiotherapy.
Hee Youn Kim, Dong Sup Lee
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Rapid Screening and Quantitative Determination of Illegal Phosphodiesterase Type 5 Inhibitors (PDE-5i) in Herbal Dietary Supplements [PDF]
Journal of Analytical Methods in Chemistry, 2021 Phosphodiesterase type 5 inhibitors (PDE-5i) are the first-line medication for oral erectile dysfunction, which are used according to the prescription of doctors. However, these substances have been found illegally in supplementary foods. The quality and
Thi Oanh Nguyen +10 more
doaj +2 more sources
Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest Signaling [PDF]
Frontiers in Oncology, 2020 Combination therapies that display cancer-killing activities through either coexistent targeting of several cellular factors or more efficient suppression of a specific pathway are generally used in cancer treatment.
Jui-Ling Hsu +7 more
doaj +2 more sources
Phosphodiesterase type 5 inhibitors after left ventricular assist device: no free lunch? [PDF]
ESC Heart Failure, 2021 E. Wilson Grandin, Jeffrey J. Teuteberg
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