Results 231 to 240 of about 69,283 (286)
Andrology, Volume 14, Issue 2, Page 466-479, February 2026.Abstract Objectives This study aimed to evaluate the pharmacodynamic effects of administering tunodafil hydrochloride with alcohol on blood pressure and heart rate in healthy Chinese males, and to investigate the mutual pharmacokinetic interactions and safety of the combination.
Dingyuan Hu +18 more
wiley +1 more source
Andrology, Volume 14, Issue 2, Page 555-570, February 2026.Abstract Background Predicting male fertility in farm animals remains a challenge. Seminal plasma (SP) contains a high amount of heterogeneous seminal extracellular vesicles (sEVs), believed involved in reproductive processes and maybe key to understanding male fertility.
Isabel Barranco +6 more
wiley +1 more source
Andrology, Volume 14, Issue 2, Page 358-367, February 2026.Abstract Background and objective The Current European Association of Urology guidelines do not provide recommendation for combination of regenerative therapies with standard therapies for erectile dysfunction. The aim of this study was to compare the efficacy of combined regenerative therapy with monotherapy for erectile dysfunction.
Alberto Quistini +12 more
wiley +1 more source
The FEBS Journal, Volume 293, Issue 3, Page 894-917, February 2026.The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen +7 more
wiley +1 more source
Insights Into circRNA‐Mediated Lipid Metabolism in Cancer Progression
Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.ABSTRACT Lipid metabolism reprogramming is one of the most prominent characteristics of cancer, but it is still unclear which regulatory pathways underlie this process in cancer cells. Circular RNAs (circRNAs) represent a novel category of non‐coding RNAs with multifaceted regulatory functions. While the biological roles of circRNAs in cancer have been
Zhiwei Miao +4 more
wiley +1 more source
Emerging Regulatory Mechanisms in Sinoatrial Node Automaticity
Journal of Cellular and Molecular Medicine, Volume 30, Issue 4, February 2026.ABSTRACT The sinoatrial node (SAN), the primary cardiac pacemaker, governs rhythmic heartbeats through spontaneous electrical impulses. While the classical “coupled‐clock” theory, integrating the membrane voltage clock (driven by cyclic ion channel activity) and the calcium clock (orchestrated by rhythmic sarcoplasmic reticulum Ca2+ release), remains ...
Hongyu Liu, Yuting Cao, Xuling Su
wiley +1 more source
Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 2, Page 274-284, February 2026.During the extension phase of the 32‐week DISCREET trial, apremilast treatment in patients with moderate to severe genital psoriasis led to clinically meaningful improvements in disease severity (modified genital PGA, overall sPGA, BSA), symptoms (genital itch, GPSS), and quality of life (DLQI, DLQI‐Q9), with safety outcomes consistent with prior ...
Joseph F. Merola +11 more
wiley +1 more source
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Phosphodiesterase Type 5 Inhibitors: Unmet Needs
Current Pharmaceutical Design, 2009Erectile dysfunction (ED) has been revolutionized during the last two decades, as several treatment options are available today. Phosphodiesterase type 5 (PDE5) inhibitors (sildenafil, tadalafil, vardenafil) are currently the first choice treatment option for ED by most physicians and patients due to their high efficacy rates and favourable safety ...
K, Hatzimouratidis, D G, Hatzichristou
openaire +2 more sources
Phosphodiesterase Type 5 Inhibitors: The Day After
European Urology, 2007Review the literature on phosphodiesterase type 5 inhibitors (PDE5-Is), addressing critical issues in their current and future use, assessing unanswered questions, and identifying research needs.A MEDLINE search was conducted on PDE5-Is, with emphasis on clinical trials and experience, for interpretation and analysis of their present and future role ...
Konstantinos, Hatzimouratidis +1 more
openaire +2 more sources
Phosphodiesterase type 5 inhibitors for erectile dysfunction
BJU International, 2005This is our first presentation of Great Drug Classes, and we start with a description of phosphodiesterase type 5 inhibitors and their use in erectile dysfunction. This is an in‐depth review of this class of drugs, offering the reader a description of how they work, in which conditions they may be particularly beneficial, and a ...
Culley C, Carson, Tom F, Lue
openaire +2 more sources