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Nonurologic applications of phosphodiesterase type 5 inhibitors
Current Sexual Health Reports, 2007Phosphodiesterase type 5 (PDE5) is an enzyme that catalyzes hydrolytic degradation of cyclic guanosine monophosphate, an essential intracellular second messenger that modulates diverse biologic processes in living cells. Three selective inhibitors of PDE5, sildenafil, vardenafil, and tadalafil, have been successfully used by millions of people ...
Rakesh C. Kukreja +2 more
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Phosphodiesterase type 5 inhibitors and endothelial function
Current Sexual Health Reports, 2007Erectile dysfunction (ED) and endothelial dysfunction are common in individuals with multiple cardiovascular risk factors (CRFs) and are longitudinal predictors of cardiovascular events. ED is associated with systemic endothelial cell activation/dysfunction independent from CRFs or from diffuse, unrecognized vascular damage.
Antonio Aversa, Roberto Bruzziches
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Chronic dosing of phosphodiesterase type 5 inhibitors
Current Sexual Health Reports, 2008Ten years ago, the introduction of sildenafil citrate for the treatment of erectile dysfunction fundamentally changed the field of sexual medicine. The sexual indications, along with the pharmacologic characteristics of this drug, led to its approval for on-demand use.
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Vision Disorders and Phosphodiesterase Type 5 Inhibitors
Drug Safety, 2009Phosphodiesterase type 5 (PDE-5) inhibitors (sildenafil, vardenafil and tadalafil) have been in widespread use for the safe and effective treatment of erectile dysfunction (ED) for nearly a decade. During that time, a relatively small number of patients have experienced adverse visual events, including nonarteritic anterior ischaemic optic neuropathy ...
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Characterization of a novel phosphodiesterase type 5 inhibitor: JNJ-10258859
European Journal of Pharmacology, 2003We have characterized a novel, potent, and selective phosphodiesterase type 5 inhibitor, JNJ-10258859 ((R)-(-)-3-(2,3-dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-1,2,3,4-tetrahydro-pyrrolo[3,4-b]quinolin-9-one). Its inhibitory effects on phosphodiesterase 1-6 were determined using enzymes partially purified from human tissues.
Yuhong, Qiu +11 more
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[Novel indications for phosphodiesterase type 5 inhibitors].
Medizinische Klinik (Munich, Germany : 1983), 2007Phosphodiesterase type 5 (PDE5) induces the breakdown of cyclic guanosine monophosphate (cGMP) in smooth muscle cells. Hence, PDE5 inhibitors promote vasodilative effects by enhancing intracellular cGMP levels. Three PDE5 inhibitors, sildenafil, vardenafil, and tadalafil, have been approved for the treatment of "erectile dysfunction" (ED).
Stephan, Rosenkranz +2 more
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Optimizing response to phosphodiesterase type 5 inhibitors
Current Sexual Health Reports, 2007Although using phosphodiesterase type 5 inhibitors to treat erectile dysfunction has been highly effective in clinical trials, many men do not achieve their desired goals and stop using the medication after a few attempts. The notion of optimizing response to pharmacologic interventions is relatively new to clinicians.
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[Erectile dysfunction and phosphodiesterase type 5 inhibitors].
Revue medicale de Bruxelles, 2003Erectile dysfunction affects 150 millions of men and its prevalence increases with age. The improvement of life expectancy will increase the worldwide prevalence to 300 million in 2025. Oral treatments are nowadays the first line therapy for the vast majority of people as they have a good reliability and tolerance and restore more spontaneity.
T, Roumeguère +2 more
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Advancements in Phosphodiesterase 5 Inhibitors: Unveiling Present and Future Perspectives
Pharmaceuticals, 2023Ahmed Elhady +2 more
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