Phosphodiesterase Type-5 Inhibitor and Oxidative Stress
International Journal of Immunopathology and Pharmacology, 2008 Erectile dysfunction (ED) is a common medical condition that affects the sexual life of millions of men worldwide. Numerous physical and psychological factors are involved in normal erectile function, including neurological, vascular, hormonal and cavernous functions. The current therapy for the condition is pharmacological and psychotherapeutic which
SPERANZA, Lorenza +7 more
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Use of the KlADH3 promoter for the quantitative production of the murine PDE5A isoforms in the yeast Kluyveromyces lactis [PDF]
, 2017 Background: Phosphodiesterases (PDE) are a superfamily of enzymes that hydrolyse cyclic nucleotides (cAMP/ cGMP), signal molecules in transduction pathways regulating crucial aspects of cell life.
Biagioni, Stefano +5 more
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Regulation of the G2/M Transition in Rodent Oocytes [PDF]
, 2010 Regulation of maturation in meiotically competent mammalian oocytes is a complex process involving the carefully coordinated exchange of signals between the somatic and germ cell compartments of the ovarian follicle via paracrine and cell–cell coupling ...
Downs, Stephen
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Erectile dysfunction in men with diabetes (literature review). Part 2
Mìžnarodnij Endokrinologìčnij Žurnal, 2021 The second part of review article highlights modern views on the diagnosis and treatment of erectile dysfunction (ED) in men with diabetes mellitus (DM). Google Scholar and PubMed databases were used to search for literature sources. The role of comorbid
Е.V. Luchytskiy, V.E. Luchytskiy
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Cyclic AMP signalling in pancreatic islets [PDF]
, 2010 Cyclic 3'5'AMP (cAMP) is an important physiological amplifier of glucose-induced insulin secretion by the pancreatic islet β-cell, where it is formed by the activity of adenylyl cyclases, which are stimulated by glucose, through elevation in ...
Furman, Brian +2 more
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Food supplements adulteration with undeclared synthetic phosphodiesterase type-5 drugs (PDE-5) inhibitors [PDF]
, 2014 The use ofplant food supplements (PFS) in developed countries is becoming increasingly popular mostly due to the consumers' widespread idea that natural products are safer and healthier than conventional pharmaceutical drugs [l].
Amaral, Joana S. +2 more
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TDP1 deficiency sensitizes human cells to base damage via distinct topoisomerase I and PARP mechanisms with potential applications for cancer therapy [PDF]
, 2013 Base damage and topoisomerase I (Top1)-linked DNA breaks are abundant forms of endogenous DNA breakage, contributing to hereditary ataxia and underlying the cytotoxicity of a wide range of anti-cancer agents.
Alagoz +50 more
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Phosphodiesterase Type 5 Inhibitor Use and Hearing Impairment [PDF]
Archives of Otolaryngology–Head & Neck Surgery, 2010 To compare use of phosphodiesterase type 5 inhibitors (PDE-5i) between participants with and without self-reported hearing impairment using logistic regression, with and without adjustment for potentially confounding sociodemographic, behavioral, and health-related characteristics.Cross-sectional.United States.A population-based sample of 11 525 men 40
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DNA single-strand break repair and spinocerebellar ataxia with axonal neuropathy-1 [PDF]
, 2007 DNA single-strand breaks (SSBs) are the commonest DNA lesions arising spontaneously in cells, and if not repaired may block transcription or may be converted into potentially lethal/clastogenic DNA double-strand breaks (DSBs).
Arnaudeau +82 more
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Tonic and phasic nitric oxide signals in hippocampal long-term potentiation [PDF]
, 2006 Nitric oxide ( NO) participates in long-term potentiation (LTP) and other forms of synaptic plasticity in many different brain areas but where it comes from and how it acts remain controversial.
Garthwaite, J, Hopper, RA
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