Results 101 to 110 of about 17,744 (296)

Alterations of Phosphodiesterases in Adrenocortical Tumors

Frontiers in Endocrinology, 2016
Alterations in the cyclic (c) AMP-dependent signaling pathway have been implicated in the majority of benign adrenocortical tumors (ACTs) causing Cushing syndrome (CS).
Fady Hannah-Shmouni, Fabio Faucz, Constantine A. Stratakis   +2 more
doaj   +1 more source

Cyclic nucleotide phosphodiesterases as therapeutic targets in cardiac hypertrophy and heart failure

, 2022
International audienceCyclic nucleotide phosphodiesterases (PDEs) modulate the neuro-hormonal regulation of cardiac function by degrading cAMP and cGMP.
Leroy, Jérôme, Vandecasteele, Grégoire, Kamel, Rima, Fischmeister, Rodolphe   +3 more
core   +1 more source

Traditional Chinese Medicine and Natural Products Targeting Right Ventricular Dysfunction in Pulmonary Arterial Hypertension: Toward Precision Cardiometabolic Therapy

iNew Medicine, EarlyView.
Natural products and traditional Chinese medicine target metabolic pathways underlying right ventricular dysfunction in pulmonary arterial hypertension. Integrating multi‐omics, artificial intelligence, and systems biology may enable precision cardiometabolic therapies to restore right ventricular metabolism and improve clinical outcomes.
Yihao Wu, Zhehui Tang, Hongwei Yao
wiley   +1 more source

Phosphodiesterases, 3\u27,5\u27-cyclic nucleotide (PDEs) in GtoPdb v.2023.1

, 2023
3\u27,5\u27-Cyclic nucleotide phosphodiesterases (PDEs, 3\u27,5\u27-cyclic-nucleotide 5\u27-nucleotidohydrolase), E.C. 3.1.4.17, catalyse the hydrolysis of a 3\u27,5\u27-cyclic nucleotide (usually cyclic AMP or cyclic GMP).
Yan, Chen, Chen Yan
core   +1 more source

Nerandomilast and the Evolving Therapeutic Paradigm in Pulmonary Fibrosis: From Mechanism to Clinical Efficacy

iNew Medicine, EarlyView.
Therapeutic mechanism, clinical efficacy and future directions for nerandomilast in pulmonary fibrosis. ABSTRACT The recent Phase III FIBRONEER trials establish nerandomilast, a novel oral phosphodiesterase 4B (PDE4B) inhibitor, as an effective therapy for idiopathic and progressive pulmonary fibrosis. By elevating cyclic adenosine monophosphate (cAMP),
Qianwen Bai, Jia Deng, Hongquan Wang, Yao Yao, Tao Wang   +4 more
wiley   +1 more source

The Construction and Application of a New Screening Method for Phosphodiesterase Inhibitors

Biosensors
Phosphodiesterases (PDEs), a superfamily of enzymes that hydrolyze cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), are recognized as a therapeutic target for various diseases.
Chunhua Gao, Zhe Wang, Xiaojing Liu, Rongzhen Sun, Shengyao Ma, Zongchen Ma, Qi Wang, Guoqiang Li, Han-Ting Zhang   +8 more
doaj   +1 more source

Corticosterone and Mitochondrial Efficiency Are Associated With Changes in DNA Oxidative Damage During an Acute Stress Response in Leach's Storm‐Petrels (Hydrobates leucorhous)

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
ABSTRACT The ability of organisms to effectively respond to challenges is critical for survival. We investigated how an acute stressor affected corticosterone, mitochondrial function, and DNA oxidative damage in a wild population of Leach's storm‐petrels (Hydrobates leucorhous).
Kayla E. Lichtner, Jack K. Dziubek, Nicole A. Joseph, Sarah E. Chapman, Tori J. Chace, Dongxiao Sun, Zachary T. Bitzer, Antoine Stier, Robert A. Mauck, Patricia L. Jones, Mark F. Haussmann   +10 more
wiley   +1 more source

Clinical Efficacy and Safety of Topical Roflumilast in Psoriasis: An Updated Systematic Review and Meta‐Analysis of Randomized Controlled Trials

JEADV Clinical Practice, EarlyView.
ABSTRACT Background Traditional first‐line topical treatments for plaque psoriasis, particularly corticosteroids and vitamin D analogs, frequently have only limited efficacy for long‐term use, and present difficulties with safety and adherence. Objectives In this systematic review and meta‐analysis of randomized controlled trials (RCTs), we assessed ...
Aimal A. Khattak, Ahmed Javed, Ummi Aiman Rahman, Rumaisa Riaz, Zeeshan Imtiaz, Hassan A. Mirza, Farman U. Khan, Muhid Khattak, Fatima Javid, Abdul Moiz Khan, Adeline L. Roy, Bibek Shrestha   +11 more
wiley   +1 more source

Partial purification and characterization of cyclic AMP phosphodiesterases from Funaria hygrometrica

, 1982
Cyclic AMP phosphodiesterase activity from chloronema cells of the moss Funaria hygrometrica has been purified 86-fold. This preparation contains more than a single phosphodiesterase activity since it hydrolyzes both 3', 5'-cAMP and 2', 3'-cAMP. It shows
Sharma, Shobhona, Johri, Man Mohan
core   +1 more source

Characteristics of the Induction of Phosphodiesterases by Cyclic Adenosine 3', 5'-Monophosphate in the Slime Mold, Dictyostelium discoideum [PDF]

, 1978
Cyclic adenosine 3', 5'-monophosphate (cAMP) stimulated the induction of cAMP-phosphodiesterases of the slime mold, Dictyostelium discoideum. The membrane phosphodiesterase was induced by more than 10-5 M of cAMP concentration, while the extracellular ...
山嵜, フミ惠, 林, 秀徳
core   +1 more source