Results 121 to 130 of about 17,744 (296)

Isolation and characterization of insulin-stimulated, high-affinity cAMP phosphodiesterases from rat liver

, 1988
The ability of glucagon to elevate intracellular cAMP concentrations in hepatocytes is antagonized by insulin.l This effect is achieved through inhibition of adenylate cyclasC and activation of specific cAMP phosphodiesterases.
Pyne, N J, Cooper, M E, Houslay, M D
core   +1 more source

Low testosterone levels in men at age 31 associates with future risk of prediabetes and type 2 diabetes: A birth cohort study

Andrology, EarlyView.
Abstract Objective We aimed to investigate the association of a low serum testosterone concentration with the risk of abnormal glucose metabolism (i.e., prediabetes and type 2 diabetes) in men at a 15‐year follow‐up. Study population and methods In a population birth cohort, men with low testosterone (testosterone < 12.1 nmol/L, n = 136) and normal ...
Tuomisto A, Pinola P, Pesonen P, Franks S, Martikainen H, Tapanainen JS, Niinimäki M, Morin‐Papunen L   +7 more
wiley   +1 more source

Polyglycolic Acid Polymer Versus Porcine Small Intestine Submucosa Graft After Plaque Incision in Peyronie's Disease: A Comparative Study

Andrology, EarlyView.
ABSTRACT Background Peyronie's disease (PD) with severe penile curvature often requires surgical correction through plaque incision and grafting (PIG). Objectives To compare surgical outcomes between polyglycolic acid polymer grafts and porcine small intestinal submucosa (SIS) grafts in patients undergoing PIG for PD.
Renan Trevisan Jost, Leonardo Seligra Lopes, Pedro Caetano Edler Zandoná, Jovânio Fernandes da Rosa, Pedro Fernandes Lessa, Felipe Placco Araujo Glina, Nívio Pascoal Teixeira, Sidney Glina   +7 more
wiley   +1 more source

cAMP and cGMP signaling cross-talk: Role of phosphodiesterases and implications for cardiac pathophysiology

, 2007
Cyclic nucleotide phosphodiesterases regulate cAMP-mediated signaling by controlling intracellular cAMP content. The cAMP-hydrolyzing activity of several families of cyclic nucleotide phosphodiesterases found in human heart is regulated by cGMP.
Zaccolo, M, Movsesian, MA, Zaccolo, Manuela   +2 more
core   +1 more source

SIEDY Diagnostic Accuracy in Assessing Erectile Dysfunction in Young Men Living With HIV

Andrology, EarlyView.
ABSTRACT Background Erectile dysfunction (ED) is a multidimensional condition commonly affecting men living with HIV. The structured interview of erectile dysfunction (SIEDY) is the only validated tool assessing organic, relational, and psychological factors contributing to ED, while dynamic penile color Doppler ultrasound (dPCDU) is a reliable method ...
Giorgio Tiecco, Federico Cesanelli, Cosimo Colangelo, Marco Di Gregorio, Andrea Delbarba, Paolo Facondo, Matteo Riva, Carlo Cappelli, Emanuele Focà, Francesco Castelli, Eugenia Quiros‐Roldan   +10 more
wiley   +1 more source

Sexual Safety Signals of Common Antidiabetic Drugs: Insights From FAERS Disproportionality Analysis

Andrology, EarlyView.
ABSTRACT Background Erectile dysfunction is a prevalent and distressing complication of diabetes mellitus that markedly affects quality of life in male patients. Although the role of diabetes in erectile dysfunction is well‐established, potential drug‐induced sexual dysfunction associated with commonly prescribed antidiabetic medications remains ...
Shan Lin, Xuefeng Ding, Xin Dang, Qingyuan Zhan   +3 more
wiley   +1 more source

Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system

, 2012
Phosphodiesterases are key enzymes in the cAMP signaling cascade. They convert cAMP in its inactive form 5′-AMP and critically regulate the intensity and the duration of cAMP-mediated signals.
Stangherlin, A, Alessandra Stangherlin, Manuela Zaccolo, Zaccolo, M, Zaccolo, M., Zaccolo, Manuela, Stangherlin, A.   +6 more
core   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Defining the Specialized Functions of cAMP Signals in an Organelle Formerly Deemed to Have No Function: The Primary Cilium

Function, 2023
Aldebaran M Hofer
doaj   +1 more source

Cyclic Nucleotides and Phosphodiesterases in Platelets

, 1999
IntroductionIt is now almost 30 years since the discovery that prostaglandin E1 (PGE1) inhibits platelet responses to aggregating agents, together with finding that the effects of this compound are mediated by adenosine 3′, 5′-cyclic monophosphate (cAMP)
Richard Haslam, Elliott Jang, Natalie Dickinson   +2 more
core   +1 more source