Results 201 to 210 of about 27,465 (289)

Impact of changed c-di-AMP levels and hypoosmotic stress on the transcriptome of <i>Haloferax volcanii</i> and on RCK domain-containing proteins. [PDF]

Microlife
Ren H, Braun F, Grünberger F, van der Does C, Grohmann D, Albers SV.   +5 more
europepmc   +1 more source

Suppression of premature ventricular complexes with the PDE5 inhibitor sildenafil: First clinical experience

Experimental Physiology, EarlyView.
Abstract The phosphodiesterase‐5 inhibitor sildenafil suppresses ventricular arrhythmias in a sheep model of drug‐induced long QT. In that study, ventricular arrhythmias were abolished by reducing premature ventricular complexes (PVCs) and delaying PVC onset, thus preventing ‘R‐on‐T’ ventricular tachycardia.
David C. Hutchings, Christopher P. Denton, Luigi Venetucci, Andrew W. Trafford   +3 more
wiley   +1 more source

Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling in <i>Dictyostelium</i>. [PDF]

Cells
Jaiswal P, Kimmel AR.
europepmc   +1 more source

PDE4-Selective Inhibition in Chronic Obstructive Pulmonary Disease and Pulmonary Fibrosis: Different Agents or Different Targets? [PDF]

Life (Basel)
Bolger GB.
europepmc   +1 more source

Sodium thiosulfate treatment rescues hyperglycaemia‐induced pronephros damage in zebrafish by upregulating nitric oxide signalling

The Journal of Physiology, EarlyView.
Abstract figure legend Sodium thiosulfate (STS) rescues the pronephros phenotype of pdx1 morphants through compensatory upregulation of nitric oxide (NO) metabolism. Zebrafish larvae injected with a control morpholino show the typical pronephros structure at 48 h post‐fertilization (hpf) with and without STS treatment.
Hannes Ott, Katrin Bennewitz, Xin Zhang, Mariia Prianichnikova, Carsten Sticht, Gernot Poschet, Jens Kroll   +6 more
wiley   +1 more source

Inhibition of phosphodiesterases 1 and 4 prevents myofibroblast transformation in Peyronie's disease. [PDF]

BJU Int
Harding SL, Ilg MM, Bustin SA, Ralph DJ, Cellek S.   +4 more
europepmc   +1 more source

Sympathetic stimulation can compensate for hypocalcaemia‐induced bradycardia in human and rabbit sinoatrial node cells

The Journal of Physiology, EarlyView.
Abstract figure legend AC: adenylyl cyclase, APT: adenosine triphosphate, AMP: adenosine monophosphate, cAMP: cyclic adenosine monophosphate, PDE: phosphodiesterase, PKA: protein kinase A, PPT: protein phosphatase, P: phosphorylation, RyR: ryanodine receptor, SERCA: sarcoplasmic/endoplasmic reticulum Ca2+‐adenosine triphosphatase, SR: sarcoplasmic ...
Moritz Linder, Tomas Stary, Gergő Bitay, Norbert Nagy, Axel Loewe   +4 more
wiley   +1 more source

β-aminopropionitrile-induced thoracic aortopathy is refractory to cilostazol and sildenafil in mice. [PDF]

PLoS One
Tyagi SC, Ito S, Hubbuch JC, Franklin MK, Howatt DA, Lu HS, Daugherty A, Sawada H.   +7 more
europepmc   +1 more source

Computational modelling of cardiac fibroblast signalling reveals a key role for Ca2+ in driving atrial fibrillation‐associated fibrosis

The Journal of Physiology, EarlyView.
Abstract figure legend A pre‐existing fibroblast signalling model was enhanced by integrating atrial‐specific components and reactions linked to atrial fibrosis and atrial fibrillation (AF). The analysis highlights the central role of Ca2⁺ signalling in driving profibrotic responses to AF‐relevant stimuli, angiotensin‐II and transforming growth factor ...
Najme Khorasani, Haibo Ni, Jeffrey J Saucerman, Dobromir Dobrev, Stefano Morotti, Eleonora Grandi   +5 more
wiley   +1 more source