Results 211 to 220 of about 27,465 (289)

PDE4 Inhibition Reduced Osteoclast Differentiation in Psoriatic Patients. [PDF]

Life (Basel)
Raimondo A, Balestrino A, Lembo S.
europepmc   +1 more source

Upstream CB1R Regulation of β‐Adrenergic Memory Consolidation

Hippocampus, Volume 36, Issue 2, March 2026.
ABSTRACT Object recognition memory (ORM) plays a key role in identifying familiar items and encoding episodic information. ORM consolidation depends on β‐adrenergic receptor (βAR) signaling and is associated with increased BDNF expression in the dorsal hippocampus.
Janine I. Rossato, Lucas Ribeiro, Thais Lima‐Silva, Raquel Araujo, Rodrigo Orvate, Anna Lyvia Azevedo, Nina Bevilaqua Cammarota, Ana Luizi Baracho, Livia Carneiro, Martín Cammarota   +9 more
wiley   +1 more source

Trends in Inhibitors, Structural Modifications, and Structure-Function Relationships of Phosphodiesterase 4: A Review. [PDF]

Biomolecules
Sánchez-Belmonte A, Matencio A, Conesa I, Vidal-Sánchez FJ, Trotta F, López-Nicolás JM.   +5 more
europepmc   +1 more source

Integrated GWAS and Fst analysis identify flowering‐time regulatory genes in maize

The Plant Genome, Volume 19, Issue 1, March 2026.
Abstract Flowering time in maize is a complex quantitative trait regulated by multiple genes, and its genetic variation mechanisms remain to be fully elucidated. In this study, we phenotypically evaluated flowering‐related traits (days to tasseling, days to pollen shedding, days to silking) across six different environments using an association ...
Dong Wang, Zhuoya Gao, Mengyue Dong, Tuan Li, Wenjing Zhou, Jialei Ou, Shiya Zhang, Shuaishuai Zhang, Xian Dong, Yalan Li, Caihui Zhang, Jiahao Tie, Yinuo Wang, Gaoyang Sun, Huiling Xie, Weihua Li, Jihua Tang, Pengshuai Yan   +17 more
wiley   +1 more source

A PDE4 shortform degrader: a first in isoform-specific PDE4 inhibition. [PDF]

FEBS J
Maurice DH.
europepmc   +1 more source

Substance Use and Sex Index version 2 (SUSI‐2): Validation of a brief questionnaire for the measurement of behaviours associated with transmission of blood borne viruses and sexually transmitted infections

Addiction, Volume 121, Issue 3, Page 670-679, March 2026.
Abstract Aims This study sought to validate a community‐acceptable Substance Use & Sex Index (SUSI) for use in substance use intervention research. SUSI aims to measure behaviours associated with the transmission of blood‐borne viruses (BBV) and sexually transmitted infections (STI) among people who use substances and incorporate contemporary sexual ...
Brendan Clifford, Raimondo Bruno, Liam Acheson, Michael E. Cecilio, Krista J. Siefried, Jack Freestone, Vincent J. Cornelisse, Brendan Crozier, Nicky Bath, Nadine Ezard   +9 more
wiley   +1 more source

Dual Inhibition of Phosphodiesterase 3 and 4 Enzymes by Ensifentrine Protects against MRSA-Induced Lung Endothelial and Epithelial Dysfunction. [PDF]

Cells
Al Matni MY, Meliton L, Dudek SM, Letsiou E.   +3 more
europepmc   +1 more source

Coumarins and Their Derivatives in Animal Models of Asthma: A Systematic Review

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 3, March 2026.
Mast cells drive early allergic asthma by releasing histamine, interleukins and prostaglandins, causing airway hyperresponsiveness, mucus overproduction and inflammation. These events sustain symptoms and promote structural remodelling, contributing to the progression of the disease.
Iêda Maria dos Santos, João Lázaro de Oliveira Rocha, Edilson Beserra de Alencar Filho, Fabrício Souza Silva   +3 more
wiley   +1 more source

Posttranslational modifications of phosphodiesterase type 4 enzymes represent novel points for therapeutic targeting. [PDF]

FEBS J
Hussain M, Tejeda GS, Baillie GS.
europepmc   +1 more source

Elevated Salivary Theobromine and Long‐Term Improvement of Periodontal Health in Two Cohort Studies

Journal of Clinical Periodontology, Volume 53, Issue 3, Page 445-454, March 2026.
ABSTRACT Background Theobromine, a methylxanthine mainly found in chocolate, has been suggested to possess various health‐promoting properties. This study aimed to investigate the long‐term effect of salivary theobromine levels on periodontitis severity using 7‐ and 10‐year follow‐up data from the prospective Studies of Health in Pomerania (SHIP‐TREND ...
Thomas Kocher, Sebastian‐Edgar Baumeister, Henry Völzke, Matthias Nauck, Peter Meisel, Karsten Suhre, Uwe Völker, Nele Friedrich, Birte Holtfreter   +8 more
wiley   +1 more source