Results 31 to 40 of about 10,168 (226)

Simvastatin overcomes the pPCK1-pLDHA-SPRINGlac axis-mediated ferroptosis and chemo-immunotherapy resistance in AKT-hyperactivated intrahepatic cholangiocarcinoma. [PDF]

Cancer Commun (Lond)
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Zhu J, Xiong Y, Zhang Y, Liang H, Cheng K, Lu Y, Cai G, Wu Y, Fan Y, Chen X, Zhu H, Ding Z, Zhang W.   +12 more
europepmc   +2 more sources

Characterization of the phosphoenolpyruvate carboxykinase (GTP) promoter-regulatory region. II. Identification of cAMP and glucocorticoid regulatory domains.

Journal of Biological Chemistry, 1986
J. Short, A. Wynshaw-Boris, H. Short, R. Hanson   +3 more
semanticscholar   +2 more sources

Mitochondrial phosphoenolpyruvate carboxykinase (GTP) and the regulation of gluconeogenesis and ketogenesis in avian liver.

Journal of Biological Chemistry, 1982
K. Ogata, Richard W. Hanson, L. J. Brady, Malcolm Watford   +3 more
openaire   +4 more sources

Integrated Metabolomics and Transcriptomic Analysis of Hepatopancreas in Different Living Status Macrobrachium nipponense in Response to Hypoxia

Antioxidants, 2021
As the basic element of aerobic animal life, oxygen participates in most physiological activities of animals. Hypoxia stress is often the subject of aquatic animal research.
Lei Xu, Wenyi Zhang, Hui Qiao, Sufei Jiang, Yiwei Xiong, Shubo Jin, Yongsheng Gong, Hongtuo Fu   +7 more
doaj   +1 more source

Inhibition of Pig Phosphoenolpyruvate Carboxykinase Isoenzymes by 3-Mercaptopicolinic Acid and Novel Inhibitors. [PDF]

PLoS ONE, 2016
There exist two isoforms of cytosolic phosphoenolpyruvate carboxykinase (PEPCK-C) in pig populations that differ in a single amino acid (Met139Leu). The isoenzymes have different kinetic properties, affecting more strongly the Km and Vmax of nucleotides.
Jorge Hidalgo, Pedro Latorre, José Alberto Carrodeguas, Adrián Velázquez-Campoy, Javier Sancho, Pascual López-Buesa   +5 more
doaj   +1 more source

Mixed Inhibition of cPEPCK by Genistein, Using an Extended Binding Site Located Adjacent to Its Catalytic Cleft. [PDF]

PLoS ONE, 2015
Cytosolic phosphoenolpyruvate carboxykinase (cPEPCK) is a critical enzyme involved in gluconeogenesis, glyceroneogenesis and cataplerosis. cPEPCK converts oxaloacetic acid (OAA) into phosphoenol pyruvate (PEP) in the presence of GTP.
Shashank Prakash Katiyar, Arpit Jain, Jaspreet Kaur Dhanjal, Durai Sundar   +3 more
doaj   +1 more source

Processing of phosphoenolpyruvate carboxykinase (GTP) RNA in vivo. [PDF]

Proceedings of the National Academy of Sciences, 1985
Nuclear RNA precursors to the mRNA for rat cytosolic phosphoenolpyruvate carboxykinase (GTP) (EC 4.1.1.32) and nuclear RNA species smaller in size than the mature enzyme mRNA have been identified by using hybridization probes specific for introns and exons from the gene.
Constantine E. Sekeris, Richard W. Hanson, Maria Hatzoglou   +2 more
openaire   +3 more sources

Relative roles of CCAAT/enhancer-binding protein beta and cAMP regulatory element-binding protein in controlling transcription of the gene for phosphoenolpyruvate carboxykinase (GTP).

Journal of Biological Chemistry, 1993
Edwards A. Park, Austin L. Gurney, Steven E. Nizielski, Parvin Hakimi, Zhodan Cao, Antoon F. M. Moorman, Richard W. Hanson   +6 more
semanticscholar   +2 more sources

Separate cis-regulatory elements confer expression of phosphoenolpyruvate carboxykinase (GTP) gene in different cell lines. [PDF]

Proceedings of the National Academy of Sciences of the United States of America, 1989
N. Benvenisty, H. Nechushtan, H. Cohen, Lea Reshef   +3 more
semanticscholar   +2 more sources

FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries. [PDF]

FEBS J
This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Cappuccio E, Holzknecht M, Petit M, Heberle A, Rytchenko Y, Seretis A, Pierri CL, Gstach H, Jansen-Dürr P, Weiss AKH.   +9 more
europepmc   +2 more sources