Results 61 to 70 of about 39,501 (165)

Phosphoenolpyruvate carboxykinase in Phycomyces blakesleeanus Bgff.

, 2014
Phosphoenolpyruvate carboxykinase (PEPCK) from Phycomyces blakesleeanus was partially purified by protamine sulfate precipitation, ammoniumsulfate precipitation, and diethylamino ethyl cellulose (DEAE) treatment.
Sandmann, Gerhard, Hilgenberg, Wilhelm
core   +1 more source

Mechanism of 3-mercaptopicolinic acid inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP).

Journal of Biological Chemistry, 1976
The hypoglycemic agent 3-mercaptopicolinic acid inhibits gluconeogenesis from lactate by isolated, perfused livers from fasted rats and guinea pigs. A 3-mercaptopicolinate concentration of 50 muM caused a sharp decrease in glucose synthesis, with virtually complete inhibition at 100 muM.
M, Jomain-Baum, V L, Schramm, R W, Hanson   +2 more
openaire   +2 more sources

Brown adipose tissue activity impacts systemic lactate clearance in male mice

The Journal of Physiology, Volume 603, Issue 22, Page 6811-6832, November 15, 2025.
Abstract figure legend Using lactate tolerance tests and in vivo 13C isotopic tracing experiments performed in male mice housed at different temperatures, this study demonstrates that the state of activation of non‐shivering thermogenesis in brown adipose tissue (BAT) impacts systemic lactate metabolism.
Rémi Montané, Yannick Jeanson, Damien Lagarde, Spiro Khoury, Léana Porcher‐Bibes, Jean Nakhle, Marie Sallese, Mélissa Parny, Isabelle Raymond‐Letron, Emma Huard, Raphael Alves de Souza, Anne Galinier, Luc Pellerin, Anne‐Karine Bouzier Sore, Jean‐Philippe Pradère, Cédric Moro, Louis Casteilla, Armelle Yart, Cédric Dray, Jean‐Charles Portais, Isabelle Ader, Audrey Carriere   +21 more
wiley   +1 more source

Direct Assay to Evaluate Phosphoenolpyruvate Carboxykinase Activity

, 2019
Phosphoenolpyruvate carboxykinase (PEPCK) is a ubiquitous enzyme found in all known groups of organisms, acting in the reversible conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) in the presence of divalent metal ion, and dependent of ...
Arlene G. Corrêa (7529045), Quezia B. Cass (1981459), Katia Celina S. Correa (7529042), Bruno S. do Amaral (7529039), Dulce H. F. de Souza (7529048)   +4 more
core   +1 more source

Advances and Deep Insights Into Lactylation: Essential Roles in Cellular Regulation and Disease Association

Journal of Cellular and Molecular Medicine, Volume 29, Issue 18, September 2025.
ABSTRACT Proteins exert biological functions not only depending on abundance but also on regulation. Lactylation is an important novel post‐translational modification (PTM) that can affect protein structure and function, playing a crucial role in signal transduction, gene expression and cellular metabolism.
Tong Pan, Can‐can Du, Ying‐jian Zhang, Zhen‐long Liu   +3 more
wiley   +1 more source

Fasting‐Induced Hepatic Gluconeogenesis Is Compromised In Anxa6−/− Mice

Journal of Cellular Physiology, Volume 240, Issue 8, August 2025.
ABSTRACT Maintaining constant blood glucose levels is essential for energizing glucose‐dependent tissues. During the fed state, insulin lowers elevated blood glucose, while in the fasted state, glucagon maintains blood glucose levels through hepatic stimulation of fatty acid oxidation, glycogenolysis, and gluconeogenesis (GNG).
Anna Alvarez‐Guaita, Marc Bernaus‐Esqué, Patricia Blanco‐Muñoz, Yangjing Liu, David Sebastian, Elsa Meneses‐Salas, Mai K. Linh Nguyen, Antonio Zorzano, Francesc Tebar, Carlos Enrich, Thomas Grewal, Carles Rentero   +11 more
wiley   +1 more source

The purification and characterization of phosphoenolpyruvate carboxykinase

, 1967
Phosphoenolpyruvate carboxykinase has been isolated from pig liver mitochondria and purified 208-fold from the initial mitochondrial accectone powder extract in good yield (48%).
Chang, Huei-Che
core  

Phosphoenolpyruvate Carboxykinase (GTP): Characterization of the Human PCK1 Gene and Localization Distal to MODY on Chromosome 20

, 1993
The human PCK1 gene encoding phosphoenolpyruvate carboxykinase (GTP) (PEPCK) was isolated and sequenced. There is 91% amino acid sequence identity (567/622 residues) between the human and the rat proteins, with conservation of intron/exon borders.
Falls, Kathleen, Chamberlain, Jeffrey S., Ting, Chao-Nan, Keith, Tim P., Burgess, Daniel L., Meisler, Miriam H.   +5 more
core   +1 more source

Induction of renal phosphoenolpyruvate carboxykinase mRNA: suppressive effect of glucose

, 1989
The mRNA for the important gluconeogenic enzyme phosphoenolpyruvate carboxykinase (GTP) (PEPCK; EC 4.1.1.32) is expressed in liver and kidney. In the kidney, acidosis is a unique and potent stimulus, whereas insulin, the major counterregulatory hormone ...
A. S. Pollock
core   +1 more source

A cAMP-regulated RNA-binding protein that interacts with phosphoenolpyruvate carboxykinase (GTP) mRNA.

Journal of Biological Chemistry, 1993
Cyclic-AMP stabilizes phosphoenolpyruvate carboxykinase (GTP) (PEPCK) mRNA against degradation. To investigate the mechanism of this effect, RNA mobility shift assays were used to determine the interaction of cellular proteins with specific domains from the mRNA.
N, Nachaliel, D, Jain, Y, Hod
openaire   +2 more sources