Results 91 to 100 of about 40,035 (261)

Canonical and non‐canonical functions of proteins regulating mitochondrial dynamics in mammalian physiology

The Journal of Physiology, EarlyView.
Abstract figure legend Mitochondria are highly dynamic organelles that continuously remodel their architecture through coordinated cycles of fusion and fission. This review examines the four key GTPases that orchestrate mitochondrial dynamics in mammals: MFN1, MFN2, OPA1, and DRP1.
Rémi Chaney, Vincent Marcangeli, Krystel Desjardins, Shima Taherkhani, Gilles Gouspillou   +4 more
wiley   +1 more source

NSAID ingestion augments training‐induced muscle hypertrophy and differentially affects muscle mRNA expression, but not strength gains, in trained men

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic outlining the impact of NSAID ingestion on resistance exercise training‐induced changes in muscle morphology, function and gene networks relative to placebo ingestion in trained males. Abstract Non‐steroidal anti‐inflammatory drugs (NSAIDs) are widely overused in sports.
Joanne E. Mallinson, Tariq Taylor, Dumitru Constantin‐Teodosiu, Despina Constantin, Martino V. Franchi, Dorothee Auer, Paul L. Greenhaff   +6 more
wiley   +1 more source

Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress

Nature Communications, 2017
Cancer cell survival under metabolic stress is a critical step for metastasis. Here, the authors show that under glucose deprivation, Snail, a key regulator of the metastatic process, promotes survival by diverting glucose to the pentose phosphate ...
Nam Hee Kim, Yong Hoon Cha, Jueun Lee, Seon-Hyeong Lee, Ji Hye Yang, Jun Seop Yun, Eunae Sandra Cho, Xianglan Zhang, Miso Nam, Nami Kim, Young-Su Yuk, So Young Cha, Yoonmi Lee, Joo Kyung Ryu, Sunghyouk Park, Jae-Ho Cheong, Sang Won Kang, Soo-Youl Kim, Geum-Sook Hwang, Jong In Yook, Hyun Sil Kim   +20 more
doaj   +1 more source

Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe healthy heart has a dynamic capacity to respond and adapt to changes in nutrient availability. Diabetes mellitus disrupts this metabolic flexibility and promotes cardiomyopathy through mechanisms that are not completely understood ...
Lee B. Bockus, Satoshi Matsuzaki, Shraddha S. Vadvalkar, Zachary T. Young, Jennifer R. Giorgione, Maria F. Newhardt, Michael Kinter, Kenneth M. Humphries   +7 more
doaj   +1 more source

Evaluation of rate law approximations in bottom-up kinetic models of metabolism. [PDF]

, 2016
BackgroundThe mechanistic description of enzyme kinetics in a dynamic model of metabolism requires specifying the numerical values of a large number of kinetic parameters.
A Bordbar, A Dräger, A Flamholz, A Joshi, A Kinoshita, AB Canelas, Andreas Dräger, AR Tzafriri, BD Bennett, Bernhard O. Palsson, Bin Du, BO Palsson, BO Palsson, C Chassagnole, D Visser, D Visser, DA Fell, Daniel C. Zielinski, E Noor, Erol S. Kavvas, F Hadlich, Garri A. Arzumanyan, GE Briggs, J Almquist, J Schellenberger, JJ Heijnen, JR Karr, Justin Tan, K Smallbone, K Takahashi, Kayla E. Ruggiero, KR Sanft, LA Segel, LA Segel, M Bier, M Salter, M Scheer, N Jamshidi, N Jamshidi, N Jamshidi, N Zamboni, O Kotte, PJ Mulquiney, R Grima, S Schnell, SA Becker, U Alon, W Liebermeister, Y-Y Liu, Zhen Zhang   +49 more
core   +4 more sources

Phosphate Resupply Differentially Impacts the Shoot and Root Proteomes of Arabidopsis thaliana Seedlings

Plant, Cell &Environment, Volume 49, Issue 3, Page 1598-1616, March 2026.
ABSTRACT Phosphate (Pi) is an essential macronutrient for plant development that is often limited in soil. Plants have evolved dynamic biochemical, physiological and morphological adaptations to cope with Pi deficiency, known as the Pi starvation response (PSR).
Milena A. Smith, Lauren E. Grubb, Kirsten H. Benidickson, Devang Mehta, William C. Plaxton, R. Glen Uhrig   +5 more
wiley   +1 more source

Mild Short‐Term Caloric Restriction Induces Coordinated Changes That Promote Lipid Deposition While Maintaining Thermogenesis Capacity in Interscapular Brown Adipose Tissue of Male Rats

The FASEB Journal, Volume 40, Issue 3, 15 February 2026.
Rats under mild caloric restriction (85% vs. ad libitum) for 2 weeks show metabolic and structural adaptations in iBAT. Caloric restriction increases glycolysis and triglyceride deposition in the tissue, leading to larger lipid droplets. It also reduces mitochondrial iBAT content, while maintaining iBAT thermogenic potential thanks to an increased ...
Giuliana Panico, Vincenzo Migliaccio, Gabriella Pinto, Anna Iliano, Gianluca Fasciolo, Martina Coletta, Paola Venditti, Maria Moreno, Angela Amoresano, Pieter de Lange, Lillà Lionetti, Assunta Lombardi   +11 more
wiley   +1 more source

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source

Molecular Mechanisms and Therapeutic Potential of DJ‐1 in Skeletal Muscle Homeostasis and Disease

Comprehensive Physiology, Volume 16, Issue 1, February 2026.
DJ‐1 protein functions as a redox‐sensing guardian in skeletal muscle by coordinating antioxidant defense, mitochondrial homeostasis, metabolic adaptation, and anti‐atrophy signaling. Enhancing its function holds promise as a potential therapeutic strategy for muscle atrophy, ALS, and metabolic myopathies.
Yue Zhang, Menghuan Li, Xiaojing Xie, Baokai Tian, Zhenwei Bao, Xuejie Yi   +5 more
wiley   +1 more source

Recent Progressions in Applications of Bioactive Polysaccharides in Food and Health Sciences: A Comprehensive Review

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Polysaccharides play a pivotal role in the development of safe and healthy foods. They ameliorate fatigue, preserve the microflora of the gastrointestinal tract, and provide health for the gut in living organisms. These biopolymers are applied for the fabrication of breakthrough drug delivery systems and potential platforms in regenerative medicine ...
M V N L Chaitanya, Bahjat Alhasso, Wadhah Hasan Alkhazali, Ashok Kumar Bishoyi, Rami Oweis, S. Renuka Jyothi, Rishiv Kalia, Laxmidhar Maharana, Ashish Singh Chauhan, Hayder Naji Sameer, Ahmed Yaseen, Zainab H. Athab, Mohaned Adil, Asghar Narmani, Bagher Farhood   +14 more
wiley   +1 more source