Results 101 to 110 of about 40,035 (261)

Targeting aerobic glycolysis combats tyrosine kinase inhibitor resistance of hepatocellular carcinoma

open access: yesInternational Journal of Cancer, Volume 158, Issue 3, Page 475-487, 1 February 2026.
Abstract Hepatocellular carcinoma (HCC) represents the predominant form of primary liver cancer and is frequently identified at a late stage, necessitating systemic therapy. However, resistance to first‐line tyrosine kinase inhibitor therapies, such as sorafenib and lenvatinib, remains a significant clinical challenge.
Longtao Zhao   +6 more
wiley   +1 more source

Distribution of nesfatin-1 expression in Bactrian camels and its impact on adipocyte glucose metabolism [PDF]

open access: yesPesquisa Veterinária Brasileira
: The study aimed to investigate the distribution and expression of nesfatin-1 in Bactrian camels and its impact on adipocyte glucose metabolism. Polyclonal antibodies against a single antigenic epitope of NUCB2/nesfatin-1 protein were prepared. Nesfatin-
Siriguleng Yu   +9 more
doaj   +1 more source

Glycolytic reprograming in Salmonella counters NOX2-mediated dissipation of ΔpH. [PDF]

open access: yes, 2020
The microbial adaptations to the respiratory burst remain poorly understood, and establishing how the NADPH oxidase (NOX2) kills microbes has proven elusive. Here we demonstrate that NOX2 collapses the ΔpH of intracellular Salmonella Typhimurium.
Chakraborty, Sangeeta   +7 more
core  

Prediabetes Associates With Musculoskeletal Alterations Independent of Total Body Adiposity

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Background Excess adiposity is a major risk factor for insulin resistance, prediabetes, and Type 2 diabetes and increases the risk for sarcopenia and osteosarcopenia later in life. It has been proposed that altered metabolic function and musculoskeletal status in people with obesity are directly linked, presumably because they share common ...
Alan Fappi   +10 more
wiley   +1 more source

Role of Th1/Th2 imbalance mediated by T cell glycolytic rate-limiting enzymes hexokinase 2, phosphofructokinase-1, and pyruvate kinase M2 in oral lichen planus

open access: yesRomanian Journal of Laboratory Medicine
We aimed to explore the role of T helper cell 1 (Th1)/Th2 imbalance mediated by T cell glycolytic rate-limiting enzymes hexokinase 2 (HK2), phosphofructokinase-1 (PEK1) and pyruvate kinase M2 (PKM2) in oral lichen planus (OLP).
Yao Min   +4 more
doaj   +1 more source

Turning up the heat: Can thermal therapy really protect muscle health in older adults?

open access: yes
Experimental Physiology, EarlyView.
Franck Brocherie   +2 more
wiley   +1 more source

Selection for Postponed Senescence in Drosophila melanogaster Reveals Distinct Metabolic Aging Trajectories Modifiable by the Angiotensin‐Converting Enzyme Inhibitor Lisinopril

open access: yesAging Cell, Volume 25, Issue 2, February 2026.
Assessment of oxygen consumption rates in young, middle‐aged, and old flies from the Drosophila B lines and long‐lived O lines revealed a significant increase in metabolic rate with aging only in B flies. Lisinopril prevented the age‐related rise in metabolic rate in B female flies.
Denise Vecchié   +3 more
wiley   +1 more source

Phosphofructokinase P fine-tunes T regulatory cell metabolism, function, and stability in systemic autoimmunity

open access: gold, 2022
Marc Scherlinger   +9 more
openalex   +1 more source

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