Results 41 to 50 of about 10,651 (216)

Lithium and Therapeutic Targeting of GSK-3

Cells, 2021
Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century, with purported benefit in gout, hangover, insomnia, and early suggestions that lithium improved psychiatric disorders.
Melinda E. Snitow, Rahul S. Bhansali, Peter S. Klein   +2 more
doaj   +1 more source

HvPHO1 Controls a Glucose 1‐Phosphate–SnRK1 Signalling Module That Coordinates Starch Accumulation in Barley Endosperm

Plant Biotechnology Journal, EarlyView.
ABSTRACT Developing barley grains must balance the use of imported sucrose between soluble sugars and storage starch, but how this balance is controlled remains unclear. Here we show that loss of the plastidial α‐glucan phosphorylase HvPHO1 causes starch and soluble sugars to accumulate concurrently in barley grains.
Yulong Li, Yujia Chen, Jing Liu, Ping Yang, Guangqi Gao, Carlos Guzmán, Qiang Xu, Yazhou Zhang, Yanlin Liu, Pengfei Qi, Mei Deng, Shoufen Dai, Jian Ma, Guoyue Chen, Jirui Wang, Youliang Zheng, Yuming Wei, Qiantao Jiang   +17 more
wiley   +1 more source

Total phosphoglucomutase activity.

, 2012
The bar chart represents the differences between potato cultivars in respect to total phosphoglucomutase activity (the unit is A340/min). Left side of the hatched bars: 2008; right side: 2009.
Mads Sønderkær (109838), Christian Feder (109843), Kåre L. Nielsen (22311), Kacper Piotr Kaminski (109834), Annabeth Høgh Petersen (109836), Lars Haastrup Pedersen (109840), Henrik Pedersen (109842)   +6 more
core   +1 more source

International consensus guidelines for phosphoglucomutase 1 deficiency (PGM1-CDG): Diagnosis, follow-up, and management

, 2020
Phosphoglucomutase 1 (PGM1) deficiency is a rare genetic disorder that affects glycogen metabolism, glycolysis, and protein glycosylation. Previously known as GSD XIV, it was recently reclassified as a congenital disorder of glycosylation, PGM1‐CDG. PGM1‐
Brasil, S, Ferreira, V, Barone, R, Fiumara, A, Ferreira, C, Altassan, R, Freeze, H, Coman, D, Radenkovic, S, Cechova, A, Edmondson, AC, Francisco, R, Falkenstein, K, Donoghue, S, et al.   +14 more
core   +1 more source

Metabolic engineering of F. oxysporum to improve its ethanol-producing capability

Frontiers in Microbiology, 2016
Fusarium oxysporum is one of the few filamentous fungi capable of fermenting ethanol directly from plant cell wall biomass. It has the enzymatic toolbox necessary to break down biomass to its monosaccharides and, under anaerobic and microaerobic ...
George E Anasontzis, Elisavet eKourtoglou, Silas G. Villas-Boâs, Dimitris G. Hatzinikolaou, Paul eChristakopoulos   +4 more
doaj   +1 more source

Excessive training does not induce mitochondrial dysfunction or impair insulin signalling within skeletal muscle

The Journal of Physiology, EarlyView.
Abstract figure legend Three weeks of overtraining in trained endurance athletes reduced exercise performance without impairing glucose tolerance. In skeletal muscle, overtraining was associated with increased expression of lipid metabolism‐related proteins, enhanced mitochondrial biogenesis and preserved insulin signalling, despite elevated oxidative ...
Geneviève J. DesOrmeaux, Henver S. Brunetta, Pierre‐Andre Barbeau, Alexandra M. Coates, Christopher Pignanelli, Fasih A. Rahman, Jamie F. Burr, Graham P. Holloway   +7 more
wiley   +1 more source

Targeting Fungal Adaptive Networks and Emerging Molecular Targets for Next-Generation Antifungal Therapeutics

Drugs and Drug Candidates
The global emergence of multidrug-resistant fungal pathogens, including Candida auris, Candida albicans, Aspergillus fumigatus, Cryptococcus neoformans, and Pneumocystis jirovecii, poses a growing threat to public health, particularly among ...
Conrad C. Achilonu
doaj   +1 more source

Wildlife genetics and disease: allozyme evolution in the wild boar (Sus scrofa) caused by a swine fever epidemy

Genetics Selection Evolution, 2000
Enzyme polymorphism at 42 loci was compared before and after a major epidemy of swine fever in wild boars from northern Vosges (France). No change was observed in the 38 monomorphic loci, but allele frequencies at the phosphoglucomutase locus PGM-2 ...
Schreiber Arnd, Klein Francois, Pesson Bernard, Lang Stéphane   +3 more
doaj   +1 more source

Successful heart transplantation in an infant with phosphoglucomutase 1 deficiency (PGM1‐CDG)

JIMD Reports, 2023
We report successful heart transplantation in a phosphoglucomutase 1 deficient (PGM1‐CDG) patient. She presented with facial dysmorphism, bifid uvula and structural heart defects. Newborn screening was positive for classic galactosemia.
Ruqaiah Altassan, Dimpna C. Albert‐Brotons, Mohammad Alowain, Zohair Al‐Halees, Jaak Jaeken, Eva Morava   +5 more
doaj   +1 more source

Life‐stage variation in Sable Shearwater (Ardenna carneipes) physiology assessed using proteomics

Ibis, Volume 168, Issue 4, Page 1500-1515, October 2026.
Life‐stage transitions in seabirds involve substantial shifts in physiological demands, yet the molecular mechanisms underpinning these changes remain poorly resolved. Here we applied untargeted data‐independent acquisition mass spectrometry (DIA‐MS) to characterize and compare the plasma proteomes of fledgling and adult Sable Shearwaters Ardenna ...
Alix M. de Jersey, Alexander L. Bond, Richard Wilson, Graeme R. Zosky, Jack Rivers‐Auty, Jennifer L. Lavers   +5 more
wiley   +1 more source