Results 1 to 10 of about 204,096 (300)

A Genome-Wide Modeling and Characterization Study of Pleckstrin Homology Domains in Chlamydomonas reinhardtii [PDF]

Plants
The function of pleckstrin homology (PH) domains is to recognize and bind to specific phosphoinositides in the membranes as part of diverse cellular signaling processes.
Münevver Aksoy, Marina Krupitskaya, Shaneen M. Singh   +2 more
doaj   +2 more sources

Functions of Oxysterol-Binding Proteins at Membrane Contact Sites and Their Control by Phosphoinositide Metabolism

Frontiers in Cell and Developmental Biology, 2021
Lipids must be correctly transported within the cell to the right place at the right time in order to be fully functional. Non-vesicular lipid transport is mediated by so-called lipid transfer proteins (LTPs), which contain a hydrophobic cavity that ...
Fubito Nakatsu, Asami Kawasaki
doaj   +1 more source

Tonic inhibition of the chloride/proton antiporter ClC-7 by PI(3,5)P2 is crucial for lysosomal pH maintenance

eLife, 2022
The acidic luminal pH of lysosomes, maintained within a narrow range, is essential for proper degrative function of the organelle and is generated by the action of a V-type H+ ATPase, but other pathways for ion movement are required to dissipate the ...
Xavier Leray, Jacob K Hilton, Kamsi Nwangwu, Alissa Becerril, Vedrana Mikusevic, Gabriel Fitzgerald, Anowarul Amin, Mary R Weston, Joseph A Mindell   +8 more
doaj   +1 more source

Phosphatidylinositol (4,5)-bisphosphate turnover by INP51 regulates the cell wall integrity pathway in "Saccharomyces cerevisiae" [PDF]

, 2004
Signal transduction pathways are important for the cell to transduce external or internal stimuli where second messengers play an important role as mediators of the stimuli. One important group of second messengers are the phosphoinositide family present
Makhtar, Mokhairi, Neagu, Daniel, Ridley, Mick, Yang, Longzhi   +3 more
core   +2 more sources

Altering phosphoinositides in high‐fat diet‐associated prostate tumor xenograft growth

MedComm, 2021
The metabolic reprogramming of phospholipids may affect intracellular signal transduction pathways. A high‐fat diet (HFD) is attributed to prostate cancer (PCa) progression, but the expression pattern and role of phospholipids in HFD‐mediated PCa ...
Mingguo Huang, Atsushi Koizumi, Shintaro Narita, Hiroki Nakanishi, Hiromi Sato, Soki Kashima, Taketoshi Nara, Sohei Kanda, Kazuyuki Numakura, Mitsuru Saito, Shigeru Satoh, Hiroshi Nanjo, Takehiko Sasaki, Tomonori Habuchi   +13 more
doaj   +1 more source

Membrane Lipids in Epithelial Polarity: Sorting out the PIPs

Frontiers in Cell and Developmental Biology, 2022
The development of cell polarity in epithelia, is critical for tissue morphogenesis and vectorial transport between the environment and the underlying tissue.
Katlynn Bugda Gwilt, Jay R. Thiagarajah
doaj   +1 more source

Class II Phosphoinositide 3-Kinases Contribute to Endothelial Cells Morphogenesis [PDF]

, 2013
PMCID: PMC3539993This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Catapano, AL, Chiozzotto, D, Falasca, M, Maffucci, T, Mavrommati, I, Norata, GD, Pineiro, R, Tibolla, G, Wheeler, AP   +8 more
core   +6 more sources

Impact of Membrane Lipids on UapA and AzgA Transporter Subcellular Localization and Activity in Aspergillus nidulans

Journal of Fungi, 2021
Recent biochemical and biophysical evidence have established that membrane lipids, namely phospholipids, sphingolipids and sterols, are critical for the function of eukaryotic plasma membrane transporters.
Mariangela Dionysopoulou, George Diallinas   +1 more
doaj   +1 more source

Targeting phosphoinositide signaling in cancer: relevant techniques to study lipids and novel avenues for therapeutic intervention

Frontiers in Cell and Developmental Biology, 2023
Phosphoinositides serve as essential players in numerous biological activities and are critical for overall cellular function. Due to their complex chemical structures, localization, and low abundance, current challenges in the phosphoinositide field ...
Alicia Llorente, Ryan M. Loughran, Brooke M. Emerling   +2 more
doaj   +1 more source

Regulation of Cell Adhesion and Migration via Microtubule Cytoskeleton Organization, Cell Polarity, and Phosphoinositide Signaling

Biomolecules, 2023
The capacity for cancer cells to metastasize to distant organs depends on their ability to execute the carefully choreographed processes of cell adhesion and migration.
Narendra Thapa, Tianmu Wen, Vincent L. Cryns, Richard A. Anderson   +3 more
doaj   +1 more source