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Current Opinion in Cell Biology, 1990
Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has ...
C L, Carpenter, L C, Cantley
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Recently, a number of cDNA clones with homology to the catalytic subunit of phosphoinositide 3-kinase have been identified, and the sequence of the first cDNA clone encoding a phosphatidylinositol 4-phosphate 5-kinase has been published. Use of both dominant-negative mutants of phosphoinositide 3-kinase and the inhibitors wortmannin and LY294002 has ...
C L, Carpenter, L C, Cantley
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Annual Review of Plant Biology, 2012
All things flow and change…even in the stillest matter there is unseen flux and movement. Attributed to Heraclitus (530–470 BC) From The Story of Philosophy by Will Durant ( 28 ) Heraclitus, a Greek philosopher, was thinking on a much larger scale than molecular signaling; however, his visionary comments are an important reminder for those studying
Wendy F, Boss, Yang Ju, Im
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All things flow and change…even in the stillest matter there is unseen flux and movement. Attributed to Heraclitus (530–470 BC) From The Story of Philosophy by Will Durant ( 28 ) Heraclitus, a Greek philosopher, was thinking on a much larger scale than molecular signaling; however, his visionary comments are an important reminder for those studying
Wendy F, Boss, Yang Ju, Im
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Nuclear phosphoinositide signaling
Frontiers in Bioscience, 2008Nuclear lipid metabolism performs a pivotal function in multiple signaling networks that mediate a variety of cellular events, including proliferation, differentiation and cell survival. The presence of phosphoinositides in the nuclei of mammalian cells is no longer in any doubt, and this has been corroborated by the detection of the enzymes ...
Keqiang, Ye, Jee-Yin, Ahn
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Phosphoinositides in endocytosis
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015The internalization and subsequent endosomal trafficking of proteins and membrane along the endocytic pathway is a fundamental cellular process. Over the last two decades, this pathway has emerged to be subject to extensive regulation by phosphoinositides (PIs), phosphorylated derivatives of the minor membrane phospholipid phosphatidylinositol ...
York Posor +2 more
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Assaying Phosphoinositide Phosphatases
2004The roles of phosphoinositide second messengers as signaling molecules in a vast array of cellular processes including cell growth, metabolism, vesicular transport, programmed cell death, and responses to extracellular signals are only beginning to be understood.
Gregory S, Taylor, Jack E, Dixon
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Phosphoinositide Recognition Domains
Traffic, 2003Domains or modules known to bind phosphoinositides have increased dramatically in number over the past few years, and are found in proteins involved in intracellular trafficking, cellular signaling, and cytoskeletal remodeling. Analysis of lipid binding by these domains and its structural basis has provided significant insight into the mechanism of ...
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1964
Publisher Summary This chapter focuses on brain phosphoinositides. Diphosphoinositide occurs in mitochondria of tissues other than brain and is rapidly labeled in vitro under conditions suitable for oxidative phosphorylation. This adds considerably to the significance of the brain phosphoinositides from a biochemical point of view. The earlier work
J N, Hawthorne, P, Kemp
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Publisher Summary This chapter focuses on brain phosphoinositides. Diphosphoinositide occurs in mitochondria of tissues other than brain and is rapidly labeled in vitro under conditions suitable for oxidative phosphorylation. This adds considerably to the significance of the brain phosphoinositides from a biochemical point of view. The earlier work
J N, Hawthorne, P, Kemp
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Phosphoinositides in Chemotaxis
2012Phosphatidylinositol lipids generated through the action of phosphinositide 3-kinase (PI3K) are key mediators of a wide array of biological responses. In particular, their role in the regulation of cell migration has been extensively studied and extends to amoeboid as well as mesenchymal migration.
Michael C, Weiger, Carole A, Parent
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ChemInform Abstract: Phosphoinositide‐Regulated Kinases and Phosphoinositide Phosphatases
ChemInform, 2001AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Nick R. Leslie +2 more
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Phosphoinositide Contributions
Science, 2012The phospholipid phosphatidylinositol 4-phosphate defines important physical properties of the cell membrane.
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