Results 311 to 320 of about 37,565 (330)

The ubiquitous phosphoinositides

Biochemical Society Transactions, 2004
There are now known to exist seven phosphoinositides all derived through various metabolic routes from the parent lipid phosphatidylinositol. With one additional metabolite, diacylglycerol, these represent a rich resource of bioactive lipids responsible for recruiting protein effectors and marking membrane compartments.
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Phosphoinositide signalling in Drosophila

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2015
Phosphoinositides (PtdInsPs) are lipids that mediate a range of conserved cellular processes in eukaryotes. These include the transduction of ligand binding to cell surface receptors, vesicular transport and cytoskeletal function. The nature and functions of PtdInsPs were initially elucidated through biochemical experiments in mammalian cells. However,
Sruthi S, Balakrishnan, Urbashi, Basu, Padinjat, Raghu   +2 more
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Phosphoinositide metabolism and oncogenes

Clinica Chimica Acta, 1989
The hydrolysis of phosphatidylinositol 4,5-bisphosphate plays important roles in growth factor- or oncogene-induced cell proliferation. However, it is still unknown whether the hydrolysis of phosphatidylinositol 4,5-bisphosphate is an essential step for cell growth. To solve this problem, we developed a monoclonal antibody against the lipid.
T, Takenawa, K, Fukami
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Pathways for phosphoinositide synthesis

Chemistry and Physics of Lipids, 1999
In eukaryotic cells, phosphatidylinositol can be phosphorylated on the inositol ring by a series of kinases to produce at least seven distinct phosphoinositides. These lipids have been implicated in a variety of cellular processes, including calcium regulation, actin rearrangement, vesicle trafficking, cell survival and mitogenesis.
K F, Tolias, L C, Cantley
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Phosphoinositides and Cellular Pathogens

2012
Phosphoinositides are considered as highly dynamic players in the spatiotemporal organization of key signaling pathways, actin cytoskeleton rearrangements, establishment of cell polarity and intracellular vesicle trafficking. Their metabolism is accurately controlled and mutations in several phosphoinositide metabolizing enzymes take part in the ...
Payrastre, Bernard, Gaits-Iacovoni, Frédérique, Sansonetti, Philippe, Tronchère, Hélène   +3 more
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Phosphoinositides

2012
Anne M. Heacock, Stephen K. Fisher
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Phosphoinositide-Regulated Kinases and Phosphoinositide Phosphatases

Chemical Reviews, 2001
N R, Leslie, R M, Biondi, D R, Alessi
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Phosphoinositides and signal transduction

Cellular and Molecular Life Sciences, 2002
Phosphoinositides comprise a family of eight minor membrane lipids which play important roles in many signal transducing pathways in the cell. Signaling through various phosphoinositides has been shown to mediate cell growth and proliferation, apoptosis, cytoskeletal changes, insulin action and vesicle trafficking.
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Receptor-Mediated Phosphoinositide Metabolism

1987
In a scant few years, the ligand-stimulated turnover of phosphatidylinositol (PI) has progressed from a curious observation to a major biochemical and pharmacological enterprise. In the 1940’s, de Hevesy (see de Hevesy, 1964) introduced the use of beta-emitting radioisotopes to biochemistry, and demonstrated that the addition of 32P-labeled inorganic ...
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Overview of Phosphoinositide Hydrolysis

Current Protocols in Pharmacology, 1998
AbstractPhosphoinositide hydrolysis is a ubiquitous, multifunctional, intracellular signaling mechanism induced (via receptor activation) by a wide variety of signaling molecules such as hormones and neurotransmitters. Phosphoinositide hydrolysis generates intracellular second messengers that regulate cell function.
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