Results 91 to 100 of about 114,080,691 (261)

Effect of phospholipase C and apolipophorin III on the structure and stability of lipophorin subspecies.

Journal of Lipid Research, 1994
Four distinct subspecies of the insect hemolymph lipoprotein, lipophorin, that range in diacylglycerol (DAG) content from approximately 100 to 1000 molecules per particle, were treated with phospholipase C.
T.K Singh, H Liu, R Bradley, D.G Scraba, R.O Ryan   +4 more
doaj   +1 more source

Oral Recombinant Human Collagen III Protects Gastric Mucosa via G‐Quadruplex‐Mediated Activation of the Pla2g4a‐Prostaglandin Axis

Advanced Science, EarlyView.
Orally administered recombinant human type III collagen protects the gastric mucosa from ethanol‐induced injury by coordinating redox homeostasis, epithelial barrier repair, and arachidonic acid–prostaglandin metabolism. Gastric digestion releases the pentapeptide GPAEF, which interacts with the Pla2g4a promoter G‐quadruplex in a structure‐dependent ...
Xinyue Lan, Qiu Dai, Yanhui Wang, Jiaxuan Gu, Chengyun Wang, Weicheng Xu, Xinru Gao, Jiageng Cheng, Wentao Geng, Xiaowen Wu, Haihang Li, Xiaoyun He, Shengwei Fu, Longjiao Zhu, Wentao Xu   +14 more
wiley   +1 more source

LPLAT7 reutilizes unsaturated 1-lysophospholipids formed during lysosomal phospholipid degradation

Journal of Lipid Research
Abstarct: Lysosomal phospholipid degradation produces two types of metabolites, either 2-lysophospholipids with saturated fatty acids in sn-1 position or 1-lysophospholipids with unsaturated fatty acids in sn-2 position.
Yang Xu, Sujith Rajan, Colin K.L. Phoon, Mindong Ren, M. Mahmood Hussain, Michael Schlame   +5 more
doaj   +1 more source

Lipid Profile of Activated Macrophages and Contribution of Group V Phospholipase A₂

Biomolecules, 2020
Macrophages activated by Interleukin (IL)-4 (M2) or LPS+ Interferon (IFN)γ (M1) perform specific functions respectively in type 2 inflammation and killing of pathogens. Group V phospholipase A2 (Pla2g5) is required for the development and functions of IL-
Masaya Koganesawa, Munehiro Yamaguchi, Sachin K. Samuchiwal, Barbara Balestrieri   +3 more
doaj   +1 more source

A Multi‐Targeting Chimeric Antigen Receptor‐T Cell Platform to Overcome Antigen Heterogeneity in the Treatment of Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
A dual‐transmembrane Bicephali CAR‐T platform simultaneously targets CD276 and NKG2D ligands to address antigen heterogeneity in non‐small cell lung cancer. By improving immune synapse formation, mitochondrial fitness, antioxidant capacity, and stem‐like persistence, this design enhances durable tumor control and provides a versatile strategy to ...
Lina Wang, Yanlei Zhang, Shuixiu Peng, Chenchen Hou, Huaqi Guo, Tianyu Zhou, Alex H. Chang, Lifeng Yan, Weining Xiong   +8 more
wiley   +1 more source

Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes [PDF]

, 2014
香川大学Kagawa University博士（医学）Abstract A-C1 protein is the product of a tumor suppressor gene negatively regulating the oncogene Ras and belongs to the HRASLS (HRAS-like suppressor) subfamily.
篠原, 尚樹, シノハラ, ナオキ, Shinohara, Naoki   +2 more
core   +1 more source

Secretory phospholipase A2 pathway in various types of lung injury in neonates and infants: a multicentre translational study

, 2011
Background: Secretory phospholipase A2 (sPLA2) is a group of enzymes involved in lung tissue inflammation and surfactant catabolism. sPLA2 plays a role in adults affected by acute lung injury and seems a promising therapeutic target.
L Sanfeliciano, M Piastra, F Cools, V Rigo, L Gentile, M Antonelli, F Camfferman, G Conti, F Vendittelli, E Capoluongo, A Minucci, D Tripodi, Daniele De Luca, B Giardina, M F Benito Zaballos, C Zuppi, J T Carbajosa, A Remesal, Ettore Capoluongo, D Pietrini, Vincent Rigo and Study group on Secretory Phospholipase in Paediatrics (SSPP): D De Luca   +20 more
core   +1 more source

Fungistatic effect of Gracilaria verrucosa on phospholipase enzymes and the cell surface hydrophobicity of Candida albicans

Dental Journal
Background: Candida albicans (C. albicans) was reported as a primary cause of oral candidiasis. Phospholipase enzymes and cell surface hydrophobicity (CSH) are involved in the pathogenesis of its infection. Gracilaria verrucosa (G. verrucosa) is reported
Basri A. Gani, Ridha Andayani, Fitri Yunita Batubara, Ifwandi Ifwandi, Dharli Syafriza, Muhammad Mas'ud Herlambang, Shiti Alya Fathirah, Ayudia Rifki   +7 more
doaj   +1 more source

N-Glycosylation regulates endothelial lipase-mediated phospholipid hydrolysis in apoE- and apoA-I-containing high density lipoproteins

Journal of Lipid Research, 2007
Endothelial lipase (EL) is a member of the triglyceride lipase gene family with high phospholipase and low triacylglycerol lipase activities and a distinct preference for hydrolyzing phospholipids in HDL. EL has five potential N-glycosylation sites, four
Danielle Skropeta, Chatri Settasatian, Monica R. McMahon, Kate Shearston, Daniela Caiazza, Kristine C. McGrath, Weijun Jin, Daniel J. Rader, Philip J. Barter, Kerry-Anne Rye   +9 more
doaj   +1 more source

Phosphatidylinositol turnover during stimulation of plasminogen activator inhibitor-1 secretion induced by oxidized low density lipoproteins in human endothelial cells.

Journal of Lipid Research, 1993
In a previous study (Latron et al. 1991. Arterioscler. Thromb. 11: 1821-1829) we have shown that oxidized low density lipoproteins (ox-LDL) stimulated the synthesis and secretion of plasminogen activator inhibitor-1 (PAI-1) by human umbilical vein ...
M Chautan, Y Latron, F Anfosso, MC Alessi, H Lafont, I Juhan-Vague, G Nalbone   +6 more
doaj   +1 more source