Results 171 to 180 of about 114,080,691 (261)

Effect of arachidonic acid and its producing enzyme phospholipase A2α on key oncogenic pathways in prostate cancer

, 2014
The dietary arachidonic acid (AA) is stored at the sn-2 position in the glycerolphospholipid of cell membrane. AA is released via the cleavage by phospholipase A2 in response to stimuli such as cytokines, growth factors and hormones.
Hua, Sheng, Yao, Mu, Dong, Qihan (R16780), Xie, Chanlu (S31301)   +3 more
core  

At the host-pathogen interface: tomato phosphoinositide-specific phospholipase C2 promotes Phytophthora infestans colonization. [PDF]

Plant Physiol
Khan M.
europepmc   +1 more source

Molecular glues: Recent advances in cereblon substrate identification and mechanistic insights

Smart Molecules, EarlyView.
Molecular glues exert diverse core biological functions by inducing or stabilizing protein–protein interactions, extending far beyond the traditional scope of targeted protein degradation. Key breakthroughs include expanded cereblon substrate recognition, sustained G protein‐coupled receptor megacomplex signaling, and the first orthosteric molecular ...
Qingyun Guan, Xiaoyu Shi, Qian Yang, Xiangyi Jiang, Xinyong Liu, Peng Zhan   +5 more
wiley   +1 more source

Screening the antimicrobial properties of snake venoms: an iterative fractionation approach. [PDF]

Access Microbiol
Fraser AJ, Wilkinson MC, Meehan CJ, Casewell NR, Roberts AP, Hubbard ATM.   +5 more
europepmc   +1 more source

PFOA Exposure Elicits Quantitative Lipidomic Changes in the Pancreas in a Mouse Model of Pancreatic Cancer

Environmental Toxicology, EarlyView.
ABSTRACT Pancreatic cancer is the fourth leading cause of cancer deaths in the US and predicted to rise to second by 2030. Several risk factors have been identified as potential contributors to pancreatic cancer development including lifestyle factors and long‐term exposure to occupational and environmental carcinogens.
Barbara A. Hocevar, Lisa M. Kamendulis
wiley   +1 more source

Phospholipase PLA2G5-triggered hemolysis emerges as a contributor to sepsis lethality. [PDF]

J Clin Invest
Cavaillon JM.
europepmc   +1 more source

Protective Effects of Bee Venom (Apis mellifera) Against Cadmium‐Induced Hepatorenal Toxicity, Oxidative Stress, and Anxiety‐Like Behavior in Rats

Environmental Toxicology, EarlyView.
ABSTRACT Cadmium (Cd) is a persistent environmental heavy metal and a major public health concern because it persists in the body for long periods and gradually accumulates in vital organs, particularly the liver, kidneys, and brain. Chronic Cd exposure promotes the excessive production of reactive oxygen species (ROS), which ultimately leads to ...
Soumaya Ghodbane, Chedli Ellijimi, Rym Elfessi, Ranya Hezzi, Khemaies Ben Rhouma, Hafedh Abdelmelek, Najet Srairi‐Abid, Mohsen Sakly, Riadh Marrouchi   +8 more
wiley   +1 more source

Serum anti-PLA2R negativity does not exclude glomerular PLA2R expression in primary membranous nephropathy. [PDF]

Biomol Biomed
Yıldırım Ş, İnci A, Karaduru Avcı A, Koç LZ, Nergiz D, Yılmaz Ü.   +5 more
europepmc   +1 more source

Identification and Validation of Biomarkers in Chronic Rhinosinusitis With Nasal Polyps and Study of Their Associated Mechanisms

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng, Hui‐Jun Qiu, Ming‐Rui Pan, Qin‐Tai Yang   +3 more
wiley   +1 more source

Multicentre comparative study of neural epidermal growth factor-like 1 protein <i>vs</i> M-type phospholipase A2 receptor-associated membranous nephropathy. [PDF]

World J Nephrol
Sathiavageesan S, Krishnan A, Sampathkumar K, Muthu R.   +3 more
europepmc   +1 more source