Results 51 to 60 of about 22,854,117 (232)

Phospholipase D regulates ferroptosis signal transduction in mouse spleen hypoxia response [PDF]

Brazilian Journal of Medical and Biological Research
High-altitude hypoxia exposure can lead to phospholipase D-mediated lipid metabolism disorder in spleen tissues and induce ferroptosis. Nonetheless, the key genes underlying hypoxia-induced splenic phospholipase D and the ferroptosis pathway remain ...
Jiayang Wang, Ying Hu, Yuzhen Xu, Qifu Long, Cunlin Gu, Chaoqun Tang, Ru Wang, Sheng Yong   +7 more
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Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant. [PDF]

PLoS ONE, 2012
BACKGROUND: Inositol 1,4,5trisphosphate (IP(3)) and diacylglycerol (DAG) are important intracellular signalling molecules in various tissues. They are generated by the phospholipase C family of enzymes, of which phospholipase C delta (PLCD) forms one ...
Fabian Runkel, Maik Hintze, Sebastian Griesing, Marion Michels, Birgit Blanck, Kiyoko Fukami, Jean-Louis Guénet, Thomas Franz   +7 more
doaj   +1 more source

Phospholipase A secreted by Legionella pneumophila destroys alveolar surfactant phospholipids.

FEMS Microbiology Letters, 2000
Destruction of alveolar surfactant phospholipids by bacterial phospholipases is suggested to be a major virulence factor involved in bacterial pneumonia.
A. Flieger, S. Gongab, M. Faigle, H. A. Mayer, U. Kehrer, J. Mussotter, P. Bartmann, B. Neumeister   +7 more
semanticscholar   +1 more source

The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells

, 2008
Activated mast cells are a major source of the eicosanoids PGD(2) and leukotriene C(4) (LTC(4)), which contribute to allergic responses. These eicosanoids are produced following the ERK1/2-dependent activation of cytosolic phospholipase A(2), thus ...
Beaven, Michael A., Gilfillan, Alasdair M., Kim, Mi-Sun, Kuehn, Hye Sun, Metcalfe, Dean D., Swindle, Emily J.   +5 more
core   +1 more source

Membrane Lipid Derivatives: Roles of Arachidonic Acid and Its Metabolites in Pancreatic Physiology and Pathophysiology

Molecules, 2023
One of the most important constituents of the cell membrane is arachidonic acid. Lipids forming part of the cellular membrane can be metabolized in a variety of cellular types of the body by a family of enzymes termed phospholipases: phospholipase A2 ...
Cándido Ortiz-Placín, Alba Castillejo-Rufo, Matías Estarás, Antonio González   +3 more
doaj   +1 more source

Inhibition of Monocyte Chemotaxis to C-C Chemokines by Antisense Oligonucleotide for Cytosolic Phospholipase A(*)

Journal of Biological Chemistry, 1996
Monocyte chemotactic protein (MCP)-1, a member of the C-C (or β) branch of the chemokine superfamily, at chemotactic concentrations, induced a rapid release of [3H]arachidonic acid but not of [14C]oleic acid from prelabeled human monocytes.
M. Locati, G. Lamorte, W. Luini, M. Introna, S. Bernasconi, A. Mantovani, S. Sozzani   +6 more
semanticscholar   +1 more source

Varespladib and cardiovascular events in patients with an acute coronary syndrome: the VISTA-16 randomized clinical trial [PDF]

, 2014
IMPORTANCE: Secretory phospholipase A2(sPLA2) generates bioactive phospholipid products implicated in atherosclerosis. The sPLA2inhibitor varespladib has favorable effects on lipid and inflammatory markers; however, its effect on cardiovascular outcomes ...
Abraham, J, Abramson, B, Acheatel, R, Ahmed, M, Akhunova, S, Alegret, JM, Alonso-Pulpón, L, Amerena, J, Amkieh, A, Amlani, M, Anand, D, Anderson, J, Antolin, JM, Areses, EL, Arkhipov, M, Aroney, C, Arstall, M, Asfour, A, Ashchi, M, Auguadro, C, Azar, R, Balog, C, Banker, D, Barbarash, O, Barbarich, V, Bash, Dianna, Battaglia, J, Belenky, D, Benczur, B, BERNI, Andrea, Berti, S, Bertolet, B, Biasucci, LM, Black, R, Blanchard, A, Blonder, R, Bokern, MJ, Bosschaert, M, Braun-Dullaeus, R, Breedveld, RW, Brennan, Danielle M., Brilakis, E, Broadwater, S, Bronisz, M, Bronzwaer, PN, Brown, A, Brown, WV, Browne, K, Burtt, D, Camp, A, Cannon, K, Cavender, JB, Cavender, Matthew A., Cendon, AA, Cervinka, P, Chandna, H, Chandra, S, Chandrashekhar, Y, Chapidze, G, Chawla, K, Chernick, R, Chronos, N, Chumburidze, V, Collins, N, Constance, C, Corrada, E, Cortés, JM, Crowley, S, Csapo, K, Cuccia, C, Dabrowski, M, Dani, S, Dart, A, Davies, C, Delafontaine, P, Della-Siega, A, DeMets, D, Den Hartog, F, den Hartoog, M, Dengler, T, Denning, S, Derlaga, B, Devlin, G, Dezsi, C, Dinnyes, J, Dobrzycki, S, Doevendans, P, Dorsel, T, Dovgalevskiy, Y, Downes, T, Drenning, D, Drozdz, J, Drzewiecki, A, East, C, Eaton, G, Edes, I, Eich, D, Elliott, J, Ermoshkina, L, Esquivias, GB, Farshid, A, Faynyk, A, Fedele, F, Fernández, JD, Ferrier, L, Feskov, O, Fineschi, M, Franco, SN, French, W, Frey, N, Fulwani, M, Gebel, J, Genth-Zotz, S, Genís, AB, Gessek, J, Gielen, S, Gillespie, E, Gniot, J, Go, B, Goloborodko, B, Goloshchekin, B, González, MJ, Gordeev, I, Gormaz, CL, Gosselin, G, Goswami, R, Goya, IL, Gunalingam, B, Gupta, S, Guseva, G, Haldis, T, Haltern, G, Harding, S, Hart, H, Heckman, MJ, Hengstenberg, C, Henry, P, Hermans, W, Herrman, J, Heuer, H, Horak, D, Horowitz, J, Hubacek, J, Huff, C, Hulinsky, V, Hutyra, M, Huynh, T, Ilmer, B, Ingelmo, JM, Janik, M, Jarne, EF, Jay, D, Jukema, J. Wouter, Kahali, D, Kancz, S, Karpenko, O, Karpenko, Y, Kashou, H, Kastelein, John J. P., Katerenchuk, O, Katzan, I, Kedhi, E, Keijzers, M, Khaisheva, L, Khintibidze, I, Kie, SH, Kiss, R, Kleiman, N, Klein, G, Klimovic, T, Klimsa, Z, Kmetzo, J, Kobulia, B, Kochmanski, M, Koenig, W, Koenig, Wolfgang, Kokis, A, Kopytsya, M, Korban, E, Kornacewicz-Jach, Z, Kostenko, V, Kovacs, Z, Koval, O, Kozhukhov, S, Kozlowski, A, Kraiz, I, Kreuzer, J, Kukuy, E, Kuznetsov, V, Lago, VN, Lai, C, Lamas, G, Lambert, C, Lapp, H, Lauer, M, Lavi, S, Leithäuser, B, Lenderink, T, Leschke, M, Libis, R, Lieberman, S, Liem, A, Lincoff, A. Michael, Linev, K, Lioy, E, Lochridge, S, Lok, D, Loussararian, A, Lu, D, Lupkovics, G, MacDonald, L, Madej, A, Magagnini, E, Mahar, L, Maly, M, Mamatsashvili, M, Mann, J, Marenzi, G, Markov, V, Marso, S, Martin Mde, M, Martin, IH, Martin, L, Mayer, O, McCullum, K, Megreladze, I, Mennuni, M, Menon, Venu, Merenda, R, Merkely, B, Miekus, P, Mikhin, V, Minisi, A, Miranda, JM, Monhart, Z, Monraats, P, Montero, JS, Moretti, L, Motovska, Z, Movahed, M, Mudra, H, Mukherjee, A, Muller, G, Musial, W, Möllmann, H, Nagy, A, Nambi, Vijay, Nava, JS, Navarro, MJ, Nicholls, Stephen J., Nierop, P, Nissen,, Nogai, K, Oei, F, Ortiz, AI, Ovcharenko, E, Paradis, JM, Parikh, K, Parker, J, Peñaranda, AS, Pfeffer, M, Piscione, F, Pleva, L, Pluta, W, Polasek, P, Polgar, P, Polk, D, Pollock, S, Ponikowski, P, Prasad, C, Prati, F, Premchand, R, Prokhorov, O, Psuja, P, Pudil, R, Pérez, MB, Rajput, R, Ramaswamy, G, Rassi, A, Reichert, P, Rekosz, J, Rezkalla, S, Richardson, J, Rivera, E, Robertson, R, Rodes-Cabau, J, Roleau, J, Romero, AJ, Romo, AI, Ronaszeki, A, Ronner, E, Rosenberg, M, Rosenson, Robert S., Rotterova, H, Rubio, AM, Ruda, M, Rudenko, L, Runquist, L, Rynkiewicz, A, Sangiorgi, G, Sanmartín, M, Sanz, M, Sanz, RR, Saucedo, J, Schwartz, G, Schwartz, Gregory G., Seigel, P, Semenka, J, Senaratne, M, Sereg, M, Shaburishvili, T, Shah, A, Shalnev, V, Shishehbor, M, Shvarts, Y, Silverman, P, Simanenkov, V, Simonyi, G, Skelding, K, Soriano, FR, Speciale, G, Spinar, J, Stellbrink, C, Steven E., Hennekens C, Stillabower, M, Strain, J, Strasser, R, Sultan, P, Suriano, P, Tans, JG, Testa, R, Thadani, U, Thompson, P, Timofeev, A, Tolerico, P., Treasure, C, Trip, MD, Trivedi, S, Troquay, R, Uchino, K, Ujda, M, Urbano, RH, Vadaganelli, P, Vakaliuk, I, Valgimigli, M, van de Wetering, ML, van der Heijden, R, van Gaal, W, van Wijk, L, Veen, G, Vertes, A, Vest, A, Vijay, N, Vishnevsky, A, Voehringer, HF, Volkova, E, Wachter, R, Werner, N, White, M, Wiley, M, Wilkins, G, Williams, J, Witkowski, A, Wright, R. Scott, Wysokinski, A, Youssef, G, Zadra, R, Zateyshchikov, D, Zishiri, E, Zubiri, JJ   +369 more
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Relation of lipid structure of sarcotubular vesicles to Ca++ transport activity

Journal of Lipid Research, 1968
The role of lipids of the sarcotubular membranes in their Ca++ uptake and Mg-ATPase activities was investigated. Treatment of the membranes with phospholipase C inhibits both processes. Treatment with phospholipase A and phospholipase D, which results in
B.P. Yu, F.D. DeMartinis, E.J. Masoro
doaj  

Distinct Roles in Signal Transduction for Each of the Phospholipase A Enzymes Present in P388D Macrophages (*)

Journal of Biological Chemistry, 1996
Receptor-stimulated arachidonic acid (AA) mobilization in P388D macrophages consists of a transient phase in which AA accumulates in the cell and a sustained phase in which AA accumulates in the incubation medium.
Jesús Balsinde, E. Dennis
semanticscholar   +1 more source

The bacterial toxin ExoU requires a host trafficking chaperone for transportation and to induce necrosis

Nature Communications, 2021
Phospholipase ExoU from Pseudomonas aeruginosa acts on plasma membrane lipids in infected cells, causing membrane rupture and host cell necrosis. Here, Deruelle et al.
Vincent Deruelle, Stéphanie Bouillot, Viviana Job, Emmanuel Taillebourg, Marie-Odile Fauvarque, Ina Attrée, Philippe Huber   +6 more
doaj   +1 more source