Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells. [PDF]
PLoS ONE, 2013 Secretory phospholipase A2 (sPLA2) is a critical component of insect and snake venoms and is secreted by mammalian leukocytes during inflammation. Elevated secretory PLA2 concentrations are associated with autoimmune diseases and septic shock. Many sPLA2'
Steffen Nyegaard +3 more
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Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019 Lysosomal phospholipase A2 (PLA2G15) is a ubiquitous enzyme uniquely characterized by a subcellular localization to the lysosome and late endosome. PLA2G15 has an acidic pH optimum, is calcium independent, and acts as a transacylase in the presence of N-acetyl-sphingosine as an acceptor.
James A, Shayman, John J G, Tesmer
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Definitions, 2020 Phospholipase A2 (148 aa, ~16 kDa) is encoded by the human PLA2G1B gene. This protein plays a role in fatty acid metabolism.
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Phospholipase A2 isolated from the venom of Crotalus durissus terrificus inactivates dengue virus and other enveloped viruses by disrupting the viral envelope. [PDF]
PLoS ONE, 2014 The Flaviviridae family includes several virus pathogens associated with human diseases worldwide. Within this family, Dengue virus is the most serious threat to public health, especially in tropical and sub-tropical regions of the world.
Vanessa Danielle Muller +8 more
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Neural epidermal growth factor-like 1 expression predicts end-stage renal disease in phospholipase A2 receptor–negative membranous nephropathy: A retrospective cohort stratified by systemic lupus erythematosus [PDF]
Journal of International Medical ResearchBackground Neural epidermal growth factor-like 1 protein has emerged as a significant antigen in membranous nephropathy, an important cause of nephrotic syndrome in adults.
Qingqing Rao +6 more
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Sucrose Treatment Enhances the Electrotransfer of DNA by Activating Phospholipase A2 [PDF]
PharmaceuticsOur previous study discovered that sucrose and other non-reducing sugars (e.g., trehalose and raffinose) could be used to improve the electrotransfer (ET) of molecular cargo, including DNA, mRNA, and ribonucleoprotein in various cell lines and primary ...
Chunxi Wang +3 more
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Anais da Academia Brasileira de Ciências, 2015 In this work, we used the Minimum Inhibitory Concentration (MIC) technique to evaluate the antibacterial potential of the apitoxin produced by Apis mellifera bees against the causative agents of tooth decay.
Luís F. Leandro +6 more
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Isolation, Characterization, and Biological Activity of Phospholipase A2 (PLA2) and Hyaluronidase from Iranian Honey Bee Venom (Apis Mellifera meda) [PDF]
مجله بیوتکنولوژی کشاورزی, 2023 ObjectiveBee venom contains various enzymes such as hyaluronidase and phospholipase A2, which have medical and pharmaceutical applications. In several studies, the activity of phospholipase A2 and hyaluronidase has been reported in different bee species,
Mahmood Nazari +2 more
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The Phospholipase A2 Superfamily: Structure, Isozymes, Catalysis, Physiologic and Pathologic Roles
International Journal of Molecular Sciences, 2023 The phospholipase A2 (PLA2) superfamily of phospholipase enzymes hydrolyzes the ester bond at the sn-2 position of the phospholipids, generating a free fatty acid and a lysophospholipid.
Shibbir Ahmed Khan, M. Ilies
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Biologics, 2022 Venom from different organisms was used in ancient times to treat a wide range of diseases, and to combat a variety of enveloped and non-enveloped viruses.
Muhammad Muzammal +5 more
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