Results 1 to 10 of about 116,044 (185)

Lactadherin inhibits secretory phospholipase A2 activity on pre-apoptotic leukemia cells. [PDF]

PLoS ONE, 2013
Secretory phospholipase A2 (sPLA2) is a critical component of insect and snake venoms and is secreted by mammalian leukocytes during inflammation. Elevated secretory PLA2 concentrations are associated with autoimmune diseases and septic shock. Many sPLA2'
Steffen Nyegaard, Valerie A Novakovic, Jan T Rasmussen, Gary E Gilbert   +3 more
doaj   +10 more sources

Neural epidermal growth factor-like 1 expression predicts end-stage renal disease in phospholipase A2 receptor–negative membranous nephropathy: A retrospective cohort stratified by systemic lupus erythematosus [PDF]

Journal of International Medical Research
Background Neural epidermal growth factor-like 1 protein has emerged as a significant antigen in membranous nephropathy, an important cause of nephrotic syndrome in adults.
Qingqing Rao, Yuan Cheng, Shuling Yue, Haiying Song, Wangyang Li, Dongli Qi, Qijun Wan   +6 more
doaj   +2 more sources

Sucrose Treatment Enhances the Electrotransfer of DNA by Activating Phospholipase A2 [PDF]

Pharmaceutics
Our previous study discovered that sucrose and other non-reducing sugars (e.g., trehalose and raffinose) could be used to improve the electrotransfer (ET) of molecular cargo, including DNA, mRNA, and ribonucleoprotein in various cell lines and primary ...
Chunxi Wang, Chun-Chi Chang, Jen-Tsan Chi, Fan Yuan   +3 more
doaj   +2 more sources

Isolation, Characterization, and Biological Activity of Phospholipase A2 (PLA2) and Hyaluronidase from Iranian Honey Bee Venom (Apis Mellifera meda) [PDF]

مجله بیوتکنولوژی کشاورزی, 2023
ObjectiveBee venom contains various enzymes such as hyaluronidase and phospholipase A2, which have medical and pharmaceutical applications. In several studies, the activity of phospholipase A2 and hyaluronidase has been reported in different bee species,
Mahmood Nazari, Hedaiat allah Rooshanfekr, Fatemeh Salabi   +2 more
doaj   +1 more source

In Silico Analysis of Honeybee Venom Protein Interaction with Wild Type and Mutant (A82V + P375S) Ebola Virus Spike Protein

Biologics, 2022
Venom from different organisms was used in ancient times to treat a wide range of diseases, and to combat a variety of enveloped and non-enveloped viruses.
Muhammad Muzammal, Muzammil Ahmad Khan, Mohammed Al Mohaini, Abdulkhaliq J. Alsalman, Maitham A. Al Hawaj, Arshad Farid   +5 more
doaj   +1 more source

Identification and characterization of the first endogenous phospholipase A2 inhibitor from a non-venomous tropical snake, Boa constrictor (Serpentes: Boidae) [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2020
Background: Endogenous phospholipase A2 inhibitors from snake blood (sbPLIs) have been isolated from several species around the world, with the primary function of self-protection against the action of toxic phospholipases A2. In American snakes, sbPLIs
Consuelo L. Fortes-Dias, Diego Henrique Fagundes Macedo, Rafaella Pereira Barbosa, Gabriel Souza-Silva, Paula Ladeira Ortolani   +4 more
doaj   +1 more source

Phospholipase A2 Biochemistry [PDF]

Cardiovascular Drugs and Therapy, 2008
The phospholipase A(2) (PLA(2)) superfamily consists of many different groups of enzymes that catalyze the hydrolysis of the sn-2 ester bond in a variety of different phospholipids. The products of this reaction, a free fatty acid, and lysophospholipid have many different important physiological roles.
Burke, John E, Dennis, Edward A
openaire   +4 more sources

Group V Phospholipase A2 Induces Leukotriene Biosynthesis in Human Neutrophils through the Activation of Group IVA Phospholipase A2 [PDF]

, 2002
We reported previously that exogenously added human group V phospholipase A2 (hVPLA2) could elicit leukotriene B4 (LTB4) biosynthesis in human neutrophils (Han, S. K., Kim, K. P., Koduri, R., Bittova, L., Munoz, N. M., Leff, A. R., Wilton, D. C., Gelb, M.
Cho, Wonhwa, Han, Sang Kyou, Kim, Kwang Pyo, Kim, Young Jun, Leff, Alan R., Munoz, Nilda M., Sano, Hiroyuki, Zhu, Xiangdong   +7 more
core   +1 more source

Inventing an arsenal: adaptive evolution and neofunctionalization of snake venom phospholipase A genes [PDF]

, 2007
Background Gene duplication followed by functional divergence has long been hypothesized to be the main source of molecular novelty. Convincing examples of neofunctionalization, however, remain rare.
Lynch Vincent J
core   +1 more source

Monolysocardiolipin: improved preparation with high yield

Journal of Lipid Research, 2011
A simple, high-yielding preparation of monolysocardiolipin (MLCL) by phospholipase A2 hydrolysis of cardiolipin (CL) in methanol on a semi-preparative scale is described. In methanol, phospholipase A2 preferentially hydrolyzes CL to MLCL.
Junhwan Kim, Charles L. Hoppel
doaj   +1 more source