Results 141 to 150 of about 343,412 (268)
ChemMedChem, Volume 21, Issue 17, 14 September 2026.A novel series of candidate AT1 receptor antagonists based on oxadiazolone‐triazole scaffolds was designed and synthesized. Most compounds reduced angiotensin II‐induced vascular contraction in an initial biological screening, with compound 7f emerging as the most active derivative.
Larissa F. L. Ferreira +5 more
wiley +1 more source
Arthritis &Rheumatology, Volume 78, Issue 9, Page 1961-1974, September 2026.Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller +16 more
wiley +1 more source
Multiple Organ‐Dysfunction Secondary to Multiple Bee Sting: A Case Report From Tanzania
Clinical Case Reports, Volume 14, Issue 9, September 2026.ABSTRACT An 8‐year‐old boy sustained over 200 bee stings, developing airway‐threatening facial oedema requiring intubation and ICU admission, with severe anemia (Hb 3.2 g/dL), rhabdomyolysis, intravascular haemolysis and marked hepatic injury (AST 2505 U/L), yet preserved renal function.
Kelvin M. Musa +5 more
wiley +1 more source
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.This review systematically examines the role of gut microbiota modulation in Alzheimer's disease, focusing on how microbial metabolites and dietary nutrients influence cognitive function and AD pathology, as well as the neuroprotective effects through the gut‐brain axis.
Binyue Xu +6 more
wiley +1 more source
Phospholipase A2 isoenzyme from porcine pancreas [PDF]
, 1975 Porcine pancreas synthesizes a prephospholipase A2 which occurs in a 5 : 95 ratio compared with the more abundant zymogen of the same enzyme* (phosphatide-acylhydrolase; EC 3.1.1.4).
Haas, Gerard H. de, Wezel, Frank M.
core
The Roles of EETs in Neurological Disorders
CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.Epoxyeicosatrienoic acids (EETs), derived from arachidonic acid (ARA) via cytochrome P450 (CYP450) enzymes, are produced in nearly all human tissues and exert a wide range of beneficial effects. This review summarizes the roles and potential mechanisms of EETs in neurological disorders, with a focus on cerebrovascular diseases, epilepsy, Parkinson's ...
Rong Tang +6 more
wiley +1 more source
, 1997 International audienceSTUDY DESIGN:Prospective study of phospholipase A2 activity in the serum and intervertebral discs of patients undergoing surgery for sciatica due to disc herniation.OBJECTIVES:To determine correlations between herniated disc ...
Piperno, M. +8 more
core +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.The molecular mechanisms contributing to impaired fertility in HIV+ males remain poorly defined. Using a human immunodeficiency virus (HIV) transgenic (Tg) rat model, we demonstrate key structural and functional sperm regulators including cation channel of sperm (CatSper)1–4 channels and mitochondrial biogenesis genes were markedly downregulated ...
Tousif Ahmed Hediyal +12 more
wiley +1 more source
Cancer‐related pain: A bidirectional modulator of cancer progression
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms involving neuroimmunology and cancer ‐neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
Junzhe He +5 more
wiley +1 more source