Results 31 to 40 of about 59,281 (286)
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2019 Lysosomal phospholipase A2 (PLA2G15) is a ubiquitous enzyme uniquely characterized by a subcellular localization to the lysosome and late endosome. PLA2G15 has an acidic pH optimum, is calcium independent, and acts as a transacylase in the presence of N-acetyl-sphingosine as an acceptor.
James A. Shayman, John J.G. Tesmer
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Lysosomal Phospholipase A2 and Phospholipidosis [PDF]
Molecular and Cellular Biology, 2006 A lysosomal phospholipase A2, LPLA2, was recently characterized and shown to have substrate specificity for phosphatidylcholine and phosphatidylethanolamine. LPLA2 is ubiquitously expressed but is most highly expressed in alveolar macrophages. Double conditional gene targeting was employed to elucidate the function of LPLA2. LPLA2-deficient mice (Lpla2-
Hiraoka, Miki +6 more
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Clinical Implant Dentistry and Related Research, Volume 24, Issue 6, Page 776-791, December 2022., 2022 Abstract Background The lateral maxillary sinus augmentation (MSA) procedure has good predictability in terms of the success of bone regeneration with a low incidence of postoperative infections, estimated between 2% and 5.6%. Although the use of antibiotics is an established and standardized prophylactic measure for MSA procedures, the addition of ...
Lorenzo Mordini +4 more
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Secreted phospholipase A2 revisited [PDF]
Journal of Biochemistry, 2011 Phospholipase A(2) (PLA(2)) catalyses the hydrolysis of the sn-2 position of glycerophospholipids to yield fatty acids and lysophospholipids. So far, more than 30 enzymes that possess PLA(2) or related activity have been identified in mammals. About one third of these enzymes belong to the secreted PLA(2) (sPLA(2)) family, which comprises low molecular
Hiroyasu Sato +3 more
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Cell Proliferation, Volume 55, Issue 12, December 2022., 2022 Transduction efficiency and immune responses hinder the application of recombinant adeno‐associated viral (rAAV) vectors in gene therapy. Here, Han et al. describe a new combined strategy for AAV capsid engineering and obtain several AAV variants with higher liver transduction efficiency and less immune activation.
Jiabao Han +9 more
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An evaluation of the chemical content and microbiological contamination of Anatolian bee venom.
PLoS ONE, 2021 Bee venom is a natural substance produced by worker bees. The aim of this research paper is to determine the characteristics of Anatolian bee venom by evaluating its chemical content and microbiological properties.
Aslı Elif Tanuğur-Samanc +1 more
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Clofazimine Induced Suicidal Death of Human Erythrocytes
Cellular Physiology and Biochemistry, 2015 Background/Aims: The antimycobacterial riminophenazine clofazimine has previously been shown to up-regulate cellular phospholipase A2 and to induce apoptosis.
Arbace Officioso +3 more
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Phospholipase A2 isolated from the venom of Crotalus durissus terrificus inactivates dengue virus and other enveloped viruses by disrupting the viral envelope. [PDF]
PLoS ONE, 2014 The Flaviviridae family includes several virus pathogens associated with human diseases worldwide. Within this family, Dengue virus is the most serious threat to public health, especially in tropical and sub-tropical regions of the world.
Vanessa Danielle Muller +8 more
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Mammalian Phospholipase A2: Phospholipase A2 Receptor
Biological and Pharmaceutical Bulletin, 2004 The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA2R regulates a variety of biological responses elicited by secretory phospholipase A2s (sPLA2s). Group IB sPLA2 acts as an endogenous ligand to induce cell proliferation and lipid mediator production ...
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Gastroenterologìa, 2015 In 49 patients, of whom 20 were diagnosed with combined lesions of the pancreas (chronic pancreatitis in the acute stage) and liver (cirrhosis class A, B by Child-Pugh) of alcoholic origin, 12 — with exacerbation of chronic pancreatitis without ...
V.H. Mishchuk, K.M. Skoropad
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