Results 31 to 40 of about 213,756 (228)
Metabolic regulation by secreted phospholipase A2
Within the phospholipase A2 (PLA2) superfamily that hydrolyzes phospholipids to yield fatty acids and lysophospholipids, the secreted PLA2 (sPLA2) enzymes comprise the largest family that contains 11 isoforms in mammals.
Hiroyasu Sato, Y. Taketomi, M. Murakami
semanticscholar +1 more source
Cytosolic phospholipase A2: physiological function and role in disease
The group IV phospholipase A2 (PLA2) family is comprised of six intracellular enzymes (GIVA, -B, -C, -D, -E, and -F) commonly referred to as cytosolic PLA2 (cPLA2)α, -β, -γ, -δ, -ε, and -ζ. They contain a Ser-Asp catalytic dyad and all except cPLA2γ have
C. Leslie
semanticscholar +1 more source
Lysosomal Phospholipase A2 and Phospholipidosis [PDF]
A lysosomal phospholipase A2, LPLA2, was recently characterized and shown to have substrate specificity for phosphatidylcholine and phosphatidylethanolamine. LPLA2 is ubiquitously expressed but is most highly expressed in alveolar macrophages. Double conditional gene targeting was employed to elucidate the function of LPLA2. LPLA2-deficient mice (Lpla2-
Hiraoka, Miki+6 more
openaire +4 more sources
Clofazimine Induced Suicidal Death of Human Erythrocytes
Background/Aims: The antimycobacterial riminophenazine clofazimine has previously been shown to up-regulate cellular phospholipase A2 and to induce apoptosis.
Arbace Officioso+3 more
doaj +1 more source
A new era of secreted phospholipase A2
Among more than 30 members of the phospholipase A2 (PLA2) superfamily, secreted PLA2 (sPLA2) enzymes represent the largest family, being Ca2+-dependent low-molecular-weight enzymes with a His-Asp catalytic dyad.
M. Murakami+4 more
semanticscholar +1 more source
Mammalian Phospholipase A2: Phospholipase A2 Receptor
The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA2R regulates a variety of biological responses elicited by secretory phospholipase A2s (sPLA2s). Group IB sPLA2 acts as an endogenous ligand to induce cell proliferation and lipid mediator production ...
openaire +4 more sources
An evaluation of the chemical content and microbiological contamination of Anatolian bee venom.
Bee venom is a natural substance produced by worker bees. The aim of this research paper is to determine the characteristics of Anatolian bee venom by evaluating its chemical content and microbiological properties.
Aslı Elif Tanuğur-Samanc+1 more
doaj +1 more source
Vijay et al. show that an age-dependent increase of phospholipase A2 group IID (PLA2G2D) in the lung contributes to worse outcomes in mice infected with SARS-CoV.
R. Vijay+7 more
semanticscholar +1 more source
In 49 patients, of whom 20 were diagnosed with combined lesions of the pancreas (chronic pancreatitis in the acute stage) and liver (cirrhosis class A, B by Child-Pugh) of alcoholic origin, 12 — with exacerbation of chronic pancreatitis without ...
V.H. Mishchuk, K.M. Skoropad
doaj +1 more source
Structure and function of lysosomal phospholipase A2 and lecithin:cholesterol acyltransferase
Lysosomal phospholipase A2 (LPLA2) and lecithin:cholesterol acyltransferase (LCAT) belong to a structurally uncharacterized family of key lipid-metabolizing enzymes responsible for lung surfactant catabolism and for reverse cholesterol transport ...
A. Glukhova+5 more
semanticscholar +1 more source