Results 61 to 70 of about 116,122 (261)
Two unusual cases of PLA2G6-associated neurodegeneration from India
Annals of Indian Academy of Neurology, 2016 Phospholipase A2-associated neurodegeneration (PLAN) comprises of three disorders with overlapping presentations. The most common of these is classical or infantile-onset phospholipase A2-associated neurodegeneration, also known as infantile neuroaxonal ...
Shilpa D Kulkarni +3 more
doaj +1 more source
Advanced Science, EarlyView.Phospholipase A2 (PLA2), a dormant enzyme, becomes lethal when activated—collapsing lungs in minutes. Our dual therapy (DOPS + varespladib) boosts survival from 0% to >90% in sepsis/ALI. A breakthrough for acute lung injury treatment. ABSTRACT This study reveals that phospholipase A2 (PLA2), normally stable and nontoxic, can be activated specifically ...
Jianyu Wang +7 more
wiley +1 more source
Tetracycline Actions Relevant to Rosacea Treatment [PDF]
, 2009 Until today, the pathogenesis of rosacea is not known in detail. Yet in recent years evidence has been accumulating that rosacea with its common symptoms such as inflammatory lesions, erythema, telangiectasia, phymatous changes, and ocular symptoms is of
Korting, Hans Christian, Schöllmann, C.
core +1 more source
Advanced Science, EarlyView.The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen +7 more
wiley +1 more source
Journal of Lipid Research, 1999 The purpose of the present study was the development and evaluation of a fluorimetric method for the screening and differential determination of phospholipase A2 and PAF-acetylhydrolase in bronchoalveolar lavage (BAL) fluid and serum.
Eirini I. Kitsiouli +2 more
doaj +1 more source
Effects of omega-3 fatty acids on arterial stiffness in patients with hypertension: a randomized pilot study. [PDF]
, 2015 BackgroundOmega-3 fatty acids prevent cardiovascular disease (CVD) events in patients with myocardial infarction or heart failure. Benefits in patients without overt CVD have not been demonstrated, though most studies did not use treatment doses (3.36 g)
Beaty, Brenda +5 more
core +1 more source
Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation
Advanced Science, EarlyView.The relative abundance of peroxidation‐resistant monounsaturated fatty acids (MUFAs) vs. peroxidation‐sensitive polyunsaturated fatty acids (PUFAs) incorporated into phospholipid (PL) is a key determinant of ferroptosis sensitivity, as the peroxidation of PL PUFA acyl chains (PUFA‐PL) disrupts membrane integrity, causing ferroptotic cell death ...
Shaojie Cui, Jin Ye
wiley +1 more source
Research progress in animal models of dry eye disease: Types, mechanisms, and application prospects
Animal Models and Experimental Medicine, EarlyView.Pivotal multifactorial animal models for translational dry eye disease research. Abstract Dry eye disease (DED) is a prevalent and complex multifactorial ocular surface disorder, leading to significant visual discomfort and diminished quality of life.
Jinshen Liu +12 more
wiley +1 more source
Lipids at the crossroad of α-synuclein function and dysfunction: Biological and pathological implications [PDF]
, 2019 Since its discovery, the study of the biological role ofα-synuclein and its pathologicalimplications has been the subject of increasing interest. The propensity to adoptdifferent conformational states governing its aggregation and fibrillation makes ...
Alza, Natalia Paola +4 more
core +1 more source
Phospholipase A2 Activates Hemostasis
Drug Target Insights, 2007 Background: Phospholipases A2 (PLA2) are aggressive enzymes that can destroy phospholipids of cell membranes. The resulting cell fragments trigger the kallikrein—mediated contact phase of coagulation.
Thomas W. Stief
doaj