Results 61 to 70 of about 213,756 (228)

Phospholipase A2 enzymes: physical structure, biological function, disease implication, chemical inhibition, and therapeutic intervention.

Chemical Reviews, 2011
1.1. Discovery of the Phospholipase A2 Superfamily Phospholipases represent one of the earliest enzyme activities to be identified and studied and the phospholipase A2 (PLA2) superfamily (see defining specificity1 in Figure 1) traces its roots to the ...
E. Dennis, Jian Cao, Y. Hsu, V. Magrioti, G. Kokotos   +4 more
semanticscholar   +1 more source

Soyasaponin and vertical microbial transmission: Maternal effect on the intestinal development and health of early chicks

iMeta, EarlyView.
This study investigates the vertical transmission of maternal microbiota in chickens and how it is modulated by maternal soyasaponin supplementation. Using a model spanning the reproductive tract, egg components, and developing chicks, we show that maternal gut and reproductive microbiota, including Bifidobacterium adolescentis (B.
Mingkun Gao, Shu Chen, Hao Fan, Peng Li, Aiqiao Liu, Dongli Li, Xiaomin Li, Yongfei Hu, Guofeng Han, Yuming Guo, Zengpeng Lv   +10 more
wiley   +1 more source

The Proteome of African Spitting and Non‐Spitting Cobra Venoms and Cytotoxicity Against Pancreatic Cancer Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT African cobra (Naja spp.) venom contains toxins dominated by proteins and peptides with inter‐ and intra‐specific variations. There are several FDA‐approved drugs from snake venom toxins from other regions, including South America and Asia. Profiling the proteomes of medically important African cobra venoms from different locations will aid in
Benedict C. Offor, Beric Muller, Lesetja R. Motadi, Lizelle A. Piater   +3 more
wiley   +1 more source

Phospholipase A2 Activates Hemostasis

Drug Target Insights, 2007
Background: Phospholipases A2 (PLA2) are aggressive enzymes that can destroy phospholipids of cell membranes. The resulting cell fragments trigger the kallikrein—mediated contact phase of coagulation.
Thomas W. Stief
doaj  

Association between enteral essential fatty acids and plasma phospholipid essential fatty acids related immune response in critically ill adults with COVID‐19: A prospective cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Coronavirus disease 2019 (COVID‐19) is a complicated disease with widely varying outcomes. Up to 20% of unvaccinated, hospitalized patients infected with COVID‐19 may die during the initial three weeks. Our research shows that COVID‐19 infection results in rapid, remarkable change in the balance between essential fatty acid ...
Vera C. Mazurak, Irma Magaly Rivas‐Serna, Sarah R. Parsons, Md Monirujjaman, Krista E. Maybank, Oleksa G. Rewa, Andrew J. Cave, Caroline Richard, M. Thomas Clandinin   +8 more
wiley   +1 more source

Identification of residues involved in substrate specificity and cytotoxicity of two closely related cutinases from Mycobacterium tuberculosis. [PDF]

PLoS ONE, 2013
The enzymes belonging to the cutinase family are serine enzymes active on a large panel of substrates such as cutin, triacylglycerols, and phospholipids. In the M.
Luc Dedieu, Carole Serveau-Avesque, Stéphane Canaan   +2 more
doaj   +1 more source

Exogenous oxidized phytosterol may modulate linoleic acid metabolism through upregulation of fatty acid desaturase in rats

Lipids, EarlyView.
Abstract Previous in vitro studies have indicated that oxidized phytosterol (OPS) exhibits some toxicity; however, the harmful effects of OPS on fatty acid metabolism are not completely understood yet. Therefore, this study examined the effects of exogenous phytosterol (PS) and OPS on growth parameters and lipid metabolism in rats.
Tomonari Koyama, Kyoichi Osada
wiley   +1 more source

Autoantibodies against Phospholipase A2 Receptor in Korean Patients with Membranous Nephropathy

PLoS ONE, 2013
The data were presented in abstract form at the 45th meeting of the American Society of Nephrology, October 30-November 04 2012, San Diego, CA, USA. Circulating autoantibodies against M-type phospholipase A2 receptor (PLA2R) are important pathogenic ...
Y. Oh, S. Yang, D. K. Kim, Shin-Wook Kang, Y. S. Kim   +4 more
semanticscholar   +1 more source

Photoaffinity labeling coupled to MS to identify peptide biological partners: Secondary reactions, for better or for worse?

Mass Spectrometry Reviews, EarlyView.
Abstract Affinity photolabeling is a smart method to study noncovalent and transient interactions and provide a submolecular picture of the contacts between interacting partners. In this review, we will focus on the identification of peptide partners using photoaffinity labeling coupled to mass spectrometry in different contexts such as in vitro with a
Astrid Walrant, Emmanuelle Sachon
wiley   +1 more source

Secretory Phospholipases A2 in Plants [PDF]

Frontiers in Plant Science, 2019
Les phospholipases sécrétées (sPLA2) dans les plantes sont un groupe croissant d'enzymes qui catalysent l'hydrolyse des glycérophospholipides sn-2 en lysophospholipides et en acides gras libres. À ce jour, environ 20 sPLA2 seulement ont été rapportés à partir de plantes.
María Elisa Mariani, María Elisa Mariani, María Elisa Mariani, Gerardo Daniel Fidelio, Gerardo Daniel Fidelio   +4 more
openaire   +5 more sources