Study of the influence of various physiologically active substances on changes in the lipid composition and phospholipase activity of damaged somatic nerves [PDF]
Известия Саратовского университета. Новая серия: Серия Химия. Биология. ЭкологияThe changes in lipid composition and phospholipase activity in damaged somatic nerves were studied against the background of the action of potassium hyaluronate and insulin-like growth factor-1.
Revin, Viktor V. +8 more
doaj +1 more source
Development of a Three-Dimensional Multiscale Agent-Based Tumor Model: Simulating Gene-Protein Interaction Profiles, Cell Phenotypes & Multicellular Patterns in Brain Cancer [PDF]
arXiv, 2006 Experimental evidence suggests that epidermal growth factor receptor (EGFR)-mediated activation of the signaling protein phospholipase C gamma plays a critical role in a cancer cell's phenotypic decision to either proliferate or to migrate at a given point in time. Here, we present a novel three-dimensional multiscale agent-based model to simulate this
arxiv
Two-loop corrections to partition function of Pohlmeyer-reduced theory for AdS_5 x S^5 superstring [PDF]
, 2011 Pohlmeyer reduction of AdS_5 x S^5 superstring leads to a set of equations of motion following from an action containing a bosonic Sp(2,2) x Sp(4)/[SU(2)]^4 gauged WZW term, an integrable potential and a fermionic part coupling bosons from the two factors.
arxiv +1 more source
Light‐Activated Pharmacological Tools for Exploring the Cholinergic System
Medicinal Research Reviews, EarlyView.ABSTRACT Cholinergic transmission plays a critical role in both the central and peripheral nervous systems, affecting processes such as learning, memory, and inflammation. Conventional cholinergic drugs generally suffer from poor selectivity and temporal precision, leading to undesired effects and limited therapeutic efficacy. Photopharmacology aims to
Alessio Colleoni +5 more
wiley +1 more source
Synthesis of photoreactive phosphatidylethanolamine and its interaction with phospholipase A2.
Journal of Lipid Research, 1994 A photoreactive derivative of phosphatidylethanolamine, N-(4-azidobenzoyl)phosphatidylethanolamine (AB-PE), was synthesized by acylation of phosphatidylethanolamine with an N-hydroxysuccinimide ester of 4-azidobenzoic acid.
R Rajasekharan, J D Kemp
doaj
Stem Cell Research, 2023 Phospholipase A2 group 6 (PLA2G6, iPLA2β or PARK14) gene encodes a calcium-independent group 6 phospholipase A2 enzyme and is associated with young-onset autosomal recessive Parkinson’s disease (PD). We generated human induced pluripotent stem cell (iPSC)
Renjitha Gopurappilly +4 more
doaj
Mapping Complex Networks: Exploring Boolean Modeling of Signal Transduction Pathways [PDF]
arXiv, 2009 In this study, we explored the utility of a descriptive and predictive bionetwork model for phospholipase C-coupled calcium signaling pathways, built with non-kinetic experimental information. Boolean models generated from these data yield oscillatory activity patterns for both the endoplasmic reticulum resident inositol-1,4,5-trisphosphate receptor ...
arxiv
Complex organics in IRAS 4A revisited with ALMA and PdBI: Striking contrast between two neighbouring protostellar cores [PDF]
, 2017 We used the Atacama Large (sub-)Millimeter Array (ALMA) and the IRAM Plateau de Bure Interferometer (PdBI) to image, with an angular resolution of 0.5$''$ (120 au) and 1$''$ (235 au), respectively, the emission from 11 different organic molecules in the protostellar binary NGC1333 IRAS 4A.
arxiv +1 more source
Recent Developments in the Optical Control of Adrenergic Signaling
Medicinal Research Reviews, EarlyView.ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi +4 more
wiley +1 more source
Liposome‐Based Interventions in Knee Osteoarthritis
Small, EarlyView.Liposomes offer new opportunities for the management of knee osteoarthritis (OA). This review examines the last decade's advances, focusing on intra‐articularly (IA) administered liposomes and liposome‐based systems as pharmaceutical carriers and lubricants, while discussing their in vivo efficacy. Functionalized liposomes (with polymers, peptides etc.)
Evgenia Mitsou, Jacob Klein
wiley +1 more source