Results 81 to 90 of about 213,756 (228)

Study of the influence of various physiologically active substances on changes in the lipid composition and phospholipase activity of damaged somatic nerves [PDF]

Известия Саратовского университета. Новая серия: Серия Химия. Биология. Экология
The changes in lipid composition and phospholipase activity in damaged somatic nerves were studied against the background of the action of potassium hyaluronate and insulin-like growth factor-1.
Revin, Viktor V., Parchaykina, Marina V., Chudaikina, Elena V., Revina, Elvira S., Molchanov, Ivan D., Simakova, Milena A., Zavarykina, Anastasia Vyacheslavovna, Grunyushkin, Igor P., Devyatkin, Arkadiy А.   +8 more
doaj   +1 more source

Modulation of oxidative stress, inflammation, and atherosclerosis by lipoprotein-associated phospholipase A2

Journal of Lipid Research, 2012
Lipoprotein-associated phospholipase A2 (Lp-PLA2), also known as platelet-activating factor acetylhydrolase (PAF-AH), is a unique member of the phospholipase A2 superfamily.
R. Rosenson, D. Stafforini
semanticscholar   +1 more source

Nimodipine reduces microglial activation in vitro as evidenced by morphological phenotype, phagocytic activity and high‐throughput RNA sequencing

British Journal of Pharmacology, EarlyView.
Background and Purpose Nimodipine, an L‐type voltage‐gated calcium channel blocker, is an approved cerebral vasorelaxant. We hypothesized that nimodipine attenuates the pro‐inflammatory shift in microglial phenotypes. Here, we analysed the effects of nimodipine on morphological and functional microglial phenotypes as well as their transcriptomic ...
István Pesti, Valentin Varga, Erda Qorri, Rita Frank, Diana Kata, Krisztián Vinga, Péter Archibald Szarvas, Ákos Menyhárt, Károly Gulya, Ferenc Bari, Eszter Farkas   +10 more
wiley   +1 more source

Synthesis of photoreactive phosphatidylethanolamine and its interaction with phospholipase A2.

Journal of Lipid Research, 1994
A photoreactive derivative of phosphatidylethanolamine, N-(4-azidobenzoyl)phosphatidylethanolamine (AB-PE), was synthesized by acylation of phosphatidylethanolamine with an N-hydroxysuccinimide ester of 4-azidobenzoic acid.
R Rajasekharan, J D Kemp
doaj  

Deficiency of Aging‐Related Gene Chitinase‐Like 4 Impairs Olfactory Epithelium Homeostasis

Cell Proliferation, EarlyView.
Deficiency of Chil4 impairs OE homeostasis through loss of sustentacular cells and a specific type of immature sensory neuron, cell cycle arrest in globose basal cells, and inflammatory activation in microglia‐like cells. ABSTRACT Mammalian olfactory epithelium (OE) undergoes consistent self‐renewal throughout life.
Tingting Wu, Weihao Li, Liujing Zhuang, Jinxia Liu, Ping Wang, Ye Gu, Yongliang Liu, Yiqun Yu   +7 more
wiley   +1 more source

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Cell Proliferation, EarlyView.
Macrophages, integral to degenerated intervertebral discs, play a critical role in disc degeneration. By performing efferocytosis, they clear apoptotic cells. This article explores the process of efferocytosis, its molecular mechanisms, potential therapeutic implications for intervertebral disc degeneration and future strategies for targeted treatments.
Shijie Chen, Haijun Zhang, Zhaoheng Wang, Daxue Zhu, Yanhu Li, Yizhi Zhang, Dongxin Wang, Shuwei Chen, Huan Liu, Xuewen Kang   +9 more
wiley   +1 more source

The salivary gland transcriptome of Varroa destructor reveals suitable targets for RNAi‐based mite control

Insect Molecular Biology, EarlyView.
RNAseq and differential expression analysis identified 15 salivary gland genes encoding secreted proteins with putative anti‐bacterial, anti‐fungal, cytolytic, digestive and immunosuppressive function. The three most highly transcribed genes were selected to study their functional importance by reverse genetics, using a non‐invasive approach of dsRNA ...
Andrea Becchimanzi, Alfonso Cacace, Martina Parziale, Giovanna De Leva, Sergio Iacopino, Giovanni Jesu, Ilaria Di Lelio, Virgilio Stillittano, Emilio Caprio, Francesco Pennacchio   +9 more
wiley   +1 more source

Adsorption of pancreatic (pro)phospholipase A2 to various physiological substrates.

Journal of Lipid Research, 1983
The adsorption of pancreatic phospholipase was studied in vitro in the presence of egg yolk lipoprotein emulsion, Intralipid emulsion, and milk fat globules.
G Nalbone, M Charbonnier-Augeire, H Lafont, R Grataroli, J L Vigne, D Lairon, C Chabert, J Leonardi, J C Hauton, R Verger   +9 more
doaj  

Phospholipase A2 enzymes and the risk of atherosclerosis.

European Heart Journal, 2012
Certain members of the phospholipase A(2) superfamily of enzymes have established causal involvement in atherosclerosis, thus at least two groups of this family of enzymes have been considered potential candidates for the prevention of cardiovascular ...
R. Rosenson, E. Hurt-Camejo
semanticscholar   +1 more source

Neutrophils in the Bone Marrow Express DEC205, Guiding Their Migration to Inflamed Tissues

Immunology, EarlyView.
In bone marrow, immature neutrophils express high levels of DEC205, necessary to mediate migration through endothelial cell layers in vitro and in vivo. During maturation and migration to peripheral tissues, expression of DEC205 is downregulated. Thus, expression of DEC205 inversely correlates with the maturation of neutrophils and is involved in ...
Shiying Jin, Xuan Lei, Sonali Singh, Alexander Enk, Karsten Mahnke   +4 more
wiley   +1 more source