Results 201 to 210 of about 1,619,431 (240)
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Deficiency of Phospholipase A2 Receptor Exacerbates Autoimmune Myocarditis in Mice
Inflammation, 2020Secretory phospholipase A2 (sPLA2) plays a critical role in the pathogenesis of various inflammatory diseases through production of pro-inflammatory eicosanoids. PLA2 receptor 1 (PLA2R) acts as a clearance receptor for sPLA2s. This study examined whether PLA2R plays a role in the pathogenesis of experimental autoimmune myocarditis using PLA2R-deficient
Hiroki Kishi +5 more
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American Journal of Nephrology
Introduction: Phospholipase A2 receptor (PLA2R) is the major autoantigen in membranous nephropathy (MN); however, the trajectories of anti-PLA2R antibodies and their prognostic implications remain unclear. Methods: In this retrospective cohort study, we analyzed 1,528 patients with PLA2R-associated MN (2011–2022), each with at least three serial ...
Siwen Gong +6 more
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Introduction: Phospholipase A2 receptor (PLA2R) is the major autoantigen in membranous nephropathy (MN); however, the trajectories of anti-PLA2R antibodies and their prognostic implications remain unclear. Methods: In this retrospective cohort study, we analyzed 1,528 patients with PLA2R-associated MN (2011–2022), each with at least three serial ...
Siwen Gong +6 more
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Modulation of the AMPA receptor by phospholipase A2: Effect of the antidepressant trimipramine
Psychiatry Research, 1994Previous results have shown that chronic administration of the antidepressant trimipramine prevents the formation of long-term potentiation in the rat hippocampus. In the present study, we compared the effects of chronic administration of trimipramine on the binding properties of hippocampal glutamate receptors and on the modulation of the DL-alpha ...
J, Bernard, M, Ohayon, G, Massicotte
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[A family of receptors for secretory phospholipases A2].
Comptes rendus des seances de la Societe de biologie et de ses filiales, 1997Venom phospholipases A2 (vPLA2's) display a large spectrum of toxic effects including neurotoxicity, myotoxicity, hypotensive, anticoagulant and proinflammatory effects. We have shown that these different types of effects are apparently linked to the existence of a diversity of very high affinity receptors (Kd values as low as 1.5 pM) for these toxic ...
G, Lambeau +5 more
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Modification of the tetrodotoxin receptor in Electrophorus electricus by phospholipase A2
Biochimica et Biophysica Acta (BBA) - Biomembranes, 1981The effects of phospholipase A2 treatment on the tetrodotoxin receptors in Electrophorus electricus was studied. (1) The binding of [3H]tetrodotoxin to electroplaque membranes was substantially reduced by treatment of the membranes with low concentrations of phospholipase A2 from a number of sources, including bee venom, Vipera russelli and Crotalus ...
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Glutaraldehyde pretreatment blocks phospholipase A2 modulation of adrenergic receptors
Life Sciences, 1985Treatment of rat cerebral cortical membranes with phospholipase A2 affects, in a parallel fashion, beta-, alpha 1- and alpha 2-adrenergic receptor binding, but not the affinity of these receptors for their respective ligands. Pretreatment of membranes with 0.1 percent glutaraldehyde blocks the effects of phospholipase A2 on adrenergic receptor binding.
R M, Cohen +3 more
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Phospholipase A2 receptor staining in pediatric idiopathic membranous glomerulopathy
Pediatric Nephrology, 2013Membranous glomerulopathy, though typically a disease of adults, does occur in children. Antiphospholipase A2 receptor (PLA2R) autoantibodies have recently been implicated as a causative agent in most cases of adult primary (idiopathic) membranous glomerulopathy.
L Nicholas, Cossey +2 more
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Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2017
To examine the expression of phospholipase A2 receptor (PLA2R) in renal tissues and the level of anti-PLA2R antibody in serum in patients with idiopathic membranous nephropathy (IMN) and secondary membranous nephropathy (SMN), and to evaluate their diagnostic value in IMN.
Xiaoxiang, Wu +8 more
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To examine the expression of phospholipase A2 receptor (PLA2R) in renal tissues and the level of anti-PLA2R antibody in serum in patients with idiopathic membranous nephropathy (IMN) and secondary membranous nephropathy (SMN), and to evaluate their diagnostic value in IMN.
Xiaoxiang, Wu +8 more
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Critical Care Management of Chimeric Antigen Receptor T-Cell Therapy Recipients
Ca-A Cancer Journal for Clinicians, 2022Sandrine Valadè +2 more
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