Results 291 to 300 of about 255,660 (330)

Alpha‐2‐adrenoreceptor agonists as analgesic drugs in equine medicine

open access: yesEquine Veterinary Education, EarlyView.
Summary Managing pain in horses is challenging despite the availability of nonsteroidal anti‐inflammatory drugs, local anaesthetics, opioids and α2‐adrenoreceptor agonists. While α2‐agonists are widely used for sedation and restraint, their analgesic properties remain underutilised.
J. A. E. Hubbell   +4 more
wiley   +1 more source

Hypoxia regulates Th17/Treg balance by altering chromatin accessibility and gene expression

open access: yesThe FEBS Journal, EarlyView.
T‐cell differentiation into Th17 or iTreg cells is key to inflammation control. Integrated RNA‐seq and ATAC‐seq analyses reveal that hypoxia induces more extensive gene expression changes in iTreg cells. Elevated levels of Hif1a and Stat3, along with increased accessibility to key transcription factor motifs, may predispose these cells toward ...
Mariana Cázares‐Olivera   +5 more
wiley   +1 more source

The PFI-index according to Aasen for prognosis and course of polytraumatized patients [PDF]

open access: yes, 1988
Baumgartner, I.   +7 more
core  

Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach

open access: yes
Clinical &Experimental Allergy, Volume 55, Issue 3, Page 247-249, March 2025.
Umesh Singh, Jonathan A. Bernstein
wiley   +1 more source

Hepatic GCGR is required for the superior weight loss and metabolic effects of a structurally related analogue of the dual GCGR/GLP‐1R agonist survodutide in mice

open access: yes
Diabetes, Obesity and Metabolism, EarlyView.
Fen Long   +7 more
wiley   +1 more source

Mammalian Phospholipase C

Annual Review of Physiology, 2013
Phospholipase C (PLC) converts phosphatidylinositol 4,5-bisphosphate (PIP2) to inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). DAG and IP3 each control diverse cellular processes and are also substrates for synthesis of other important signaling molecules. PLC is thus central to many important interlocking regulatory networks.
Ganesh, Kadamur, Elliott M, Ross
openaire   +2 more sources

Selective phospholipase C activation

BioEssays, 1991
AbstractPhospholipase C is a family of cellular proteins believed to play a significant role in the intracellular signaling mechanisms utilized by diverse hormones. One class of hormones, polypeptide growth factors, elicits its influence on cellular function through stimulation of cell surface receptor tyrosine kinase activity.
M, Wahl, G, Carpenter
openaire   +2 more sources

Phospholipase C

2012
Phospholipase C (PLC) family members constitute a family of diverse enzymes. Thirteen different family members have been cloned. These family members have unique structures that mediate diverse functions. Although PLC family members all appear to signal through the bi-products of cleaving phospholipids, it is clear that each family member, and at times
openaire   +2 more sources

Regulation of phospholipase C isozymes

Progress in Growth Factor Research, 1992
Phosphatidylinositol bisphosphate hydrolysis is an immediate response to many hormones, including growth factors. The hydrolysis of phosphatidylinositol bisphosphate is catalyzed by phosphatidylinositol-specific phospholipase C. A number of phospholipase C isozymes have been identified.
G, Jones, G, Carpenter
openaire   +2 more sources

Regulation of platelet phospholipase C

Philosophical Transactions of the Royal Society of London. B, Biological Sciences, 1988
We have investigated factors affecting the activation of phospholipase C in human platelets. Prior exposure of platelets to phorbol esters that stimulate protein kinase C inhibits the activation of phospholipase C in response to a variety of receptor-directed agonists, including x- and y-thrombin and thromboxane A 2
S E, Rittenhouse   +4 more
openaire   +2 more sources

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