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Phospholipase C from pseudomonas fluorescens
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1971Abstract Phospholipase C found in the growth medium of Pseudomonas fluorescens was purified 2500-fold by (NH 4 ) 2 SO 4 fractionation and successive chromatography on Sephadex G-100, Sephadex G-200 and DEAE-Sephadex A-50 columns. Phosphatidyl ethanolamine rather than phosphatidyl choline was hydrolyzed extensively under our experimental conditions.
O, Doi, S, Nojima
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Inhibition of phospholipase A2 and phospholipase C by polyamines
Archives of Biochemistry and Biophysics, 1978Abstract The polyamines spermine, spermidine, and putrescine inhibit the activity of phospholipase A2 (Naja naja) and phospholipase C (Clostridium welchii) on phospholipid vesicles and mitochondrial membranes as sources of substrate phospholipids. The inhibitory effect is highest for spermine and lowest for putrescine.
A M, Sechi +4 more
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2003
Publisher Summary This chapter provides an overview of mammalian phospholipase C. The hydrolysis of cellular phospholipids leads to the formation of various bioactive lipid mediators, acting either as extracellular signaling molecules or as intracellular second messengers. A well-known second messenger-forming system involving phospholipid hydrolysis
Martina Schmidt +4 more
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Publisher Summary This chapter provides an overview of mammalian phospholipase C. The hydrolysis of cellular phospholipids leads to the formation of various bioactive lipid mediators, acting either as extracellular signaling molecules or as intracellular second messengers. A well-known second messenger-forming system involving phospholipid hydrolysis
Martina Schmidt +4 more
openaire +1 more source
Protein kinase C‐dependent stimulation of phospholipase D in phospholipase C‐treated fibroblasts
Lipids, 1993AbstractTreatment of [14C]choline‐ or [14C]ethanolamine‐labeled NIH 3T3 fibroblasts withBacillus cereus phosphatidylcholine‐specific phospholipase C (PLC) enhanced phospholipase D (PLD)‐mediated hydrolysis of the respective14C‐labeled phospholipids. PLD activity was stimulated by 1.5 U/mL of POLC and by 100 nM of the protein kinase C (PKC) activator ...
Z, Kiss, N, Garamszegi
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Gan to kagaku ryoho. Cancer & chemotherapy, 1997
N-Myristoylated PCI peptide, myr-PCI, originally developed based on the PCI sequence of PLC- gamma 2, inhibited activity of purified PLC isoforms in vitro, and external stimuli-dependent IP3 formation in Swiss 3T3 cells. When myr-PCI was added to KMS-8 cells, derived from familial adenomatous polyposis patients, it also suppressed the serum-dependent ...
Y, Homma, M, Homma
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N-Myristoylated PCI peptide, myr-PCI, originally developed based on the PCI sequence of PLC- gamma 2, inhibited activity of purified PLC isoforms in vitro, and external stimuli-dependent IP3 formation in Swiss 3T3 cells. When myr-PCI was added to KMS-8 cells, derived from familial adenomatous polyposis patients, it also suppressed the serum-dependent ...
Y, Homma, M, Homma
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Mammalian phosphoinositide-specific phospholipase C
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1999Mammalian phosphoinositide-specific phospholipases C (PI-PLCs) are involved in most receptor-mediated signal transduction pathways. The mammalian isozymes employ a modular arrangement of domains to achieve a regulated production of two key second messengers.
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2018
Plant phospholipases C (PLCs) that hydrolyze the phosphodiesteric linkages of the head group of phospholipids can be grouped into three major types—non-specific PLC (NPC), phosphoinositide-specific PLC (PI-PLC), and glycosylphosphatidylinositol (GPI)-PLC—according to the specificity of substrate and the cellular functions. After an overview of the main
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Plant phospholipases C (PLCs) that hydrolyze the phosphodiesteric linkages of the head group of phospholipids can be grouped into three major types—non-specific PLC (NPC), phosphoinositide-specific PLC (PI-PLC), and glycosylphosphatidylinositol (GPI)-PLC—according to the specificity of substrate and the cellular functions. After an overview of the main
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Science's STKE, 2001
The family of phospholipase C (PLC) isoforms can be divided into three classes β, γ, and δ. Song et al. have identified a fourth class of PLC, PLCε, which has sequence similarity to the Caenorhabditis elegans PLC210, including two putative Ras-interacting domains (CDC25-like domain and an RA ...
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The family of phospholipase C (PLC) isoforms can be divided into three classes β, γ, and δ. Song et al. have identified a fourth class of PLC, PLCε, which has sequence similarity to the Caenorhabditis elegans PLC210, including two putative Ras-interacting domains (CDC25-like domain and an RA ...
openaire +1 more source