Results 131 to 140 of about 117,202 (259)

Distinctly altered TRPC3 and TRPC6 expression patterns in human Alzheimer's disease cortex and hippocampus

Brain Pathology, EarlyView.
Divergent remodeling of TRPC channels occurs in Alzheimer's disease, with TRPC3 increased in neurons and reactive astrocytes and TRPC6 reduced in pyramidal neurons. These alterations may contribute to calcium dysregulation, neuroinflammation, and synaptic dysfunction during AD progression.
Xingyong Chen, Zhengjun Wang, Jiaxing Wang, Dehui Kong, Xusheng Wang, Lu Lu, Peter T. Nelson, Fu‐Ming Zhou, Francesca‐Fang Liao   +8 more
wiley   +1 more source

Correction to "Development and Evaluation of Indole-Based Phospholipase D Inhibitors for Lung Cancer Immunotherapy". [PDF]

J Med Chem
Song D, Lim SH, Kim Y, Lee H, Kim T, Lim H, Min DS, Han G.   +7 more
europepmc   +1 more source

Reduction of Membrane Lipid Metabolism in Postharvest Hami Melon Fruits by n-Butanol to Mitigate Chilling Injury and the Cloning of Phospholipase D-β Gene. [PDF]

Foods, 2023
Huang S, Bi Y, Li H, Liu C, Wang X, Wang X, Lei Y, Zhang Q, Wang J.   +8 more
europepmc   +1 more source

From patient to tumor organoid: Culture protocol choice controls glioblastoma tumor architecture and identity

Brain Pathology, EarlyView.
How glioblastoma organoids are made shapes what they become. Fragment‐based cultures preserve extracellular matrix networks, cellular diversity, and primary tumor identity, whereas dissociation‐based cultures shift toward growth‐adapted states and simplified microenvironments. Abstract Patient‐derived tumor organoids are widely used in cancer research,
Jana Slovackova, Ondrej Bernatik, Katarina Cimborova, Martin Barak, Michal Hendrych, Karolina Kocourkova, Marie Sulcova, Jaroslav Olha, Katerina Amruz Cerna, Zdenek Hodny, Radim Jancalek, Dasa Bohaciakova   +11 more
wiley   +1 more source

Golgi retention of KIT in gastrointestinal stromal tumour cells is phospholipase D activity-dependent. [PDF]

Sci Rep
Obata Y, Natsume M, Shiina I, Takahashi T, Nishida T.   +4 more
europepmc   +1 more source

A New Phospholipase D from Moritella sp. JT01: Biochemical Characterization, Crystallization and Application in the Synthesis of Phosphatidic Acid. [PDF]

Int J Mol Sci, 2022
Wang F, Mao X, Deng F, Cui R, Li L, Liu S, Yang B, Lan D, Wang Y.   +8 more
europepmc   +1 more source

Non‐canonical PKG1 regulation in cardiovascular health and disease

British Journal of Pharmacology, EarlyView.
It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley   +1 more source

Luminal Phospholipase D Attacks Bacterial Membranes in Dictyostelium discoideum Phagosomes. [PDF]

Mol Microbiol
Lamrabet O, Munoz-Ruiz R, Ayadi I, Bourbon A, Pain E, Oddy J, Cosson P.   +6 more
europepmc   +1 more source

Interactome Analysis of Human Phospholipase D and Phosphatidic Acid-Associated Protein Network. [PDF]

Mol Cell Proteomics, 2022
Kattan RE, Han H, Seo G, Yang B, Lin Y, Dotson M, Pham S, Menely Y, Wang W.   +8 more
europepmc   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source